Using simulations in the design of an anesthesia system

J. Robert Sneyd; Chao Dong; Christopher D. Reeve; Emmanuel C. Ifeachor

doi:10.1177/104687810103200208

Using simulations in the design of an anesthesia system

J. Robert Sneyd, Chao Dong, Christopher D. Reeve, Emmanuel C. Ifeachor

University of Plymouth

Research output: Contribution to journal › Article › peer-review

Abstract

The authors are developing a closed-loop system for intravenous anesthesia in humans. Using published pharmacokinetic data for the intravenous anesthetic agent, propofol, they have generated a population of "virtual patients " and simulated their response to induction and maintenance of intravenous anesthesia using a feedback system based on an electroencephalogram derivative. Their simulations suggested that the proposed system would accommodate patients with widely varying pharmacokinetic characteristics. The system was subsequently tested in humans, and successfully induced and maintained anesthesia in 7 volunteers.

Original language	English
Pages (from-to)	205-214
Number of pages	10
Journal	Simulation and Gaming
Volume	32
Issue number	2
DOIs	https://doi.org/10.1177/104687810103200208
Publication status	Published - Jun 2001

ASJC Scopus subject areas

General Social Sciences
Computer Science Applications

Keywords

Anesthesia
Bispectral index
Closed-loop system
Computer controlled anesthesia
EEG
Modeling
Pharmacodynamics
Pharmacokinetics
Simulation
Virtual patients

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10.1177/104687810103200208

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keywords = "Anesthesia, Bispectral index, Closed-loop system, Computer controlled anesthesia, EEG, Modeling, Pharmacodynamics, Pharmacokinetics, Simulation, Virtual patients",

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KW - Bispectral index

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KW - Computer controlled anesthesia

KW - EEG

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KW - Pharmacodynamics

KW - Pharmacokinetics

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KW - Virtual patients

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Using simulations in the design of an anesthesia system

Abstract

ASJC Scopus subject areas

Keywords

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