TY - JOUR
T1 - Use of the Freund Clock Drawing Test within the Mini-Cog as a screening tool for cognitive impairment in elderly patients with or without cancer
AU - Ketelaars, Lore
AU - Pottel, Lies
AU - Lycke, Michelle
AU - Goethals, Laurence
AU - Ghekiere, Véronique
AU - Santy, Linda
AU - Boterberg, Tom
AU - Van Den Noortgate, Nele
AU - Pottel, Hans
AU - Debruyne, Philip R.
PY - 2013/4
Y1 - 2013/4
N2 - Objectives: We aimed to determine an optimal cut-off score for the Clock Drawing Test (CDT), scored by the scale of Freund, for efficient screening for cognitive impairment in elderly (cancer) patients within a Comprehensive Geriatric Assessment (CGA) and to compare the Freund CDT to the Mini-Cog. Materials and Methods: Data of 221 elderly (≥70. years) patients, comprising of an OncoGeriatric (OG) and General Geriatric (GG) group, were retrospectively reviewed. All patients were evaluated with both the CDT and Mini Mental State Examination (MMSE) as the gold standard. Receiver Operating Characteristics (ROC) analysis was used to determine diagnostic performance. A pre-established algorithm was applied to retrieve Mini-Cog results through a combination of the CDT and the 3-Word Delayed Recall (3-WDR) test (included within MMSE). Results: Data of 105 OG and 116 GG patients were evaluated. Potential cognitive impairment (MMSE. ≤ 23) was detected in 29.5% and 65.8% of patients, respectively. The CDT showed good diagnostic accuracy in the OG (0.88 ± 0.03) and GG (0.85 ± 0.03) group, based on the area under the ROC curve (AUC ± SE). CDT (cut-off ≤ 4) provided good sensitivity (80.7%) and specificity (81.1%) in the OG group and excellent sensitivity (89.6%) and moderate specificity (51.3%) in the GG group. Addition of the 3-WDR test, to form the Mini-Cog, resulted in similar positive and negative predictive values for the OG group and higher negative predictive value for the GG group. Conclusion: These data suggest that the Freund CDT, at the cut-off score of ≤ 4, is promising for use within a CGA. The Mini-Cog might be preferable in the GG population.
AB - Objectives: We aimed to determine an optimal cut-off score for the Clock Drawing Test (CDT), scored by the scale of Freund, for efficient screening for cognitive impairment in elderly (cancer) patients within a Comprehensive Geriatric Assessment (CGA) and to compare the Freund CDT to the Mini-Cog. Materials and Methods: Data of 221 elderly (≥70. years) patients, comprising of an OncoGeriatric (OG) and General Geriatric (GG) group, were retrospectively reviewed. All patients were evaluated with both the CDT and Mini Mental State Examination (MMSE) as the gold standard. Receiver Operating Characteristics (ROC) analysis was used to determine diagnostic performance. A pre-established algorithm was applied to retrieve Mini-Cog results through a combination of the CDT and the 3-Word Delayed Recall (3-WDR) test (included within MMSE). Results: Data of 105 OG and 116 GG patients were evaluated. Potential cognitive impairment (MMSE. ≤ 23) was detected in 29.5% and 65.8% of patients, respectively. The CDT showed good diagnostic accuracy in the OG (0.88 ± 0.03) and GG (0.85 ± 0.03) group, based on the area under the ROC curve (AUC ± SE). CDT (cut-off ≤ 4) provided good sensitivity (80.7%) and specificity (81.1%) in the OG group and excellent sensitivity (89.6%) and moderate specificity (51.3%) in the GG group. Addition of the 3-WDR test, to form the Mini-Cog, resulted in similar positive and negative predictive values for the OG group and higher negative predictive value for the GG group. Conclusion: These data suggest that the Freund CDT, at the cut-off score of ≤ 4, is promising for use within a CGA. The Mini-Cog might be preferable in the GG population.
KW - Cancer
KW - Clock drawing test
KW - Cognitive impairment
KW - Comprehensive Geriatric Assessment
KW - Elderly
UR - http://www.scopus.com/inward/record.url?scp=84875632717&partnerID=8YFLogxK
U2 - 10.1016/j.jgo.2012.10.175
DO - 10.1016/j.jgo.2012.10.175
M3 - Article
C2 - 24071542
AN - SCOPUS:84875632717
SN - 1879-4068
VL - 4
SP - 174
EP - 182
JO - Journal of Geriatric Oncology
JF - Journal of Geriatric Oncology
IS - 2
ER -