Unusual side effects of lamotrigine therapy.

KB Das, C Harris, DPL Smyth, JH Cross

Research output: Contribution to journalArticlepeer-review

Abstract

An 8-year-old boy developed tremor, unsteadiness, chorea, and eye movement abnormalities on starting lamotrigine for myoclonic jerks. Investigations for a neurodegenerative disorder were negative. Symptoms and signs resolved on stopping lamotrigine. He was well and asymptomatic on follow-up after 4 years. Another 7-year-old boy who started on lamotrigine for suspected absence seizures developed abnormalities of eye movement with associated cognitive decline, which also resolved on discontinuing the medication. Eye movement abnormalities, involuntary movements, and behavioral changes appear to be unusual side effects of lamotrigine therapy.
Original languageEnglish
Pages (from-to)479-480
Number of pages0
JournalJ Child Neurol
Volume18
Issue number7
DOIs
Publication statusPublished - Jul 2003

Keywords

  • Anticonvulsants
  • Child
  • Child Behavior Disorders
  • Chorea
  • Cognition Disorders
  • Epilepsy
  • Absence
  • Humans
  • Lamotrigine
  • Male
  • Myoclonus
  • Ocular Motility Disorders
  • Tremor
  • Triazines

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