Abstract
OBJECTIVES: Uropathogenic and invasive Escherichia coli O25:H4-ST131 isolates producing CTX-M-15 extended-spectrum beta-lactamase (ESBL) enzymes have recently been shown to be disseminated across the globe. In the UK, many CTX-M-15 ESBL-producing E. coli strains have been previously defined as belonging to the epidemic strains A-E, as determined by PFGE. The present study was carried out to define the relationship between these two groups of pathogenic E. coli. METHODS: Multilocus sequence typing and PFGE were used for molecular characterization of a collection of 61 ESBL-producing E. coli isolates from across the UK. RESULTS: Strains A to E all belonged to the ST131 clone, further underscoring the epidemiological importance of this lineage. CONCLUSIONS: The future spread of the ST131 clone, and its UK variants, should be monitored closely and the pathogenic mechanisms explaining their success should be investigated.
Original language | English |
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Pages (from-to) | 1241-1244 |
Number of pages | 0 |
Journal | J Antimicrob Chemother |
Volume | 62 |
Issue number | 6 |
DOIs | |
Publication status | Published - Dec 2008 |
Keywords
- Bacterial Typing Techniques
- Cluster Analysis
- DNA Fingerprinting
- Electrophoresis
- Gel
- Pulsed-Field
- Escherichia coli
- Escherichia coli Infections
- Genotype
- Humans
- Molecular Epidemiology
- Sequence Analysis
- DNA
- Serotyping
- United Kingdom
- beta-Lactamases