Transformation of CLL to ALCL: the role of clonality studies in diagnostic molecular haematopathology

Richard Colling*, Daniel Royston, Elizabeth Soilleux

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Clonality studies greatly assist in the diagnosis of challenging haematopathology cases. These robust and standardised tests aid the detection of clonal lymphoid populations and may assist in lymphocyte subtyping. In this case report, a gentleman presented with a high-grade transformation of a B cell neoplasm which histologically and immunophenotypically mimicked a T cell anaplastic large-cell lymphoma. With the aid of T cell and B cell receptor clonality studies, it was demonstrated that this tumour was in fact of B cell lineage. This report exemplifies the role of these increasingly used and relatively new molecular tests in unusual and difficult lymphoma presentations and highlights potential pitfalls in the interpretation of their results.

Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalJournal of Hematopathology
Volume9
Issue number3
DOIs
Publication statusPublished - 1 Sept 2016
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Hematology

Keywords

  • Clonality
  • Lymphoma
  • Molecular diagnostics
  • PCR

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