Titanium and strontium-doped phosphate glasses as vehicles for strontium ion delivery to cells.

Nilay Lakhkar; Neel EA Abou; Vehid Salih; Jonathan Campbell Knowles

doi:10.1177/0885328210362125

Titanium and strontium-doped phosphate glasses as vehicles for strontium ion delivery to cells.

Nilay Lakhkar^*, Neel EA Abou, Vehid Salih, Jonathan Campbell Knowles

^*Corresponding author for this work

Peninsula Dental School

University College London

Research output: Contribution to journal › Article › peer-review

Abstract

This study investigated the use of a Ti-containing quaternary phosphate glass system P(2)O(5)-Na(2)O-CaO-TiO(2) as a vehicle for strontium ion delivery to cells. Four glass compositions were manufactured: 0.5P(2)O(5)-0.15Na(2)O-0.05TiO(2)-(0.3 - x)CaO-xSrO (x = 0, 0.01, 0.03, and 0.05). Structural characterization revealed that sodium calcium phosphate is the dominant phase in all the glasses. Degradation studies demonstrated highly linear glass degradation, with Sr-containing glasses degrading at higher rates than the Sr-free glass. Biocompatibility studies using MG63 cells showed that the Sr-containing glasses possess excellent cell attachment and growth, particularly over short periods (~4 days).

Original language	English
Pages (from-to)	877-893
Number of pages	0
Journal	J Biomater Appl
Volume	25
Issue number	8
DOIs	https://doi.org/10.1177/0885328210362125
Publication status	Published - May 2011

Keywords

Biocompatible Materials
Cell Adhesion
Cell Line
Cell Proliferation
Drug Carriers
Glass
Humans
Ions
Materials Testing
Oxides
Pharmaceutical Vehicles
Strontium
Surface Properties
Titanium
X-Ray Diffraction

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@article{6a52516f0e85468c896cf75a33e992bc,

title = "Titanium and strontium-doped phosphate glasses as vehicles for strontium ion delivery to cells.",

abstract = "This study investigated the use of a Ti-containing quaternary phosphate glass system P(2)O(5)-Na(2)O-CaO-TiO(2) as a vehicle for strontium ion delivery to cells. Four glass compositions were manufactured: 0.5P(2)O(5)-0.15Na(2)O-0.05TiO(2)-(0.3 - x)CaO-xSrO (x = 0, 0.01, 0.03, and 0.05). Structural characterization revealed that sodium calcium phosphate is the dominant phase in all the glasses. Degradation studies demonstrated highly linear glass degradation, with Sr-containing glasses degrading at higher rates than the Sr-free glass. Biocompatibility studies using MG63 cells showed that the Sr-containing glasses possess excellent cell attachment and growth, particularly over short periods (~4 days).",

keywords = "Biocompatible Materials, Cell Adhesion, Cell Line, Cell Proliferation, Drug Carriers, Glass, Humans, Ions, Materials Testing, Oxides, Pharmaceutical Vehicles, Strontium, Surface Properties, Titanium, X-Ray Diffraction",

author = "Nilay Lakhkar and Abou, {Neel EA} and Vehid Salih and Knowles, {Jonathan Campbell}",

year = "2011",

month = may,

doi = "10.1177/0885328210362125",

language = "English",

volume = "25",

pages = "877--893",

journal = "J Biomater Appl",

issn = "1530-8022",

number = "8",

}

TY - JOUR

T1 - Titanium and strontium-doped phosphate glasses as vehicles for strontium ion delivery to cells.

AU - Lakhkar, Nilay

AU - Abou, Neel EA

AU - Salih, Vehid

AU - Knowles, Jonathan Campbell

PY - 2011/5

Y1 - 2011/5

N2 - This study investigated the use of a Ti-containing quaternary phosphate glass system P(2)O(5)-Na(2)O-CaO-TiO(2) as a vehicle for strontium ion delivery to cells. Four glass compositions were manufactured: 0.5P(2)O(5)-0.15Na(2)O-0.05TiO(2)-(0.3 - x)CaO-xSrO (x = 0, 0.01, 0.03, and 0.05). Structural characterization revealed that sodium calcium phosphate is the dominant phase in all the glasses. Degradation studies demonstrated highly linear glass degradation, with Sr-containing glasses degrading at higher rates than the Sr-free glass. Biocompatibility studies using MG63 cells showed that the Sr-containing glasses possess excellent cell attachment and growth, particularly over short periods (~4 days).

AB - This study investigated the use of a Ti-containing quaternary phosphate glass system P(2)O(5)-Na(2)O-CaO-TiO(2) as a vehicle for strontium ion delivery to cells. Four glass compositions were manufactured: 0.5P(2)O(5)-0.15Na(2)O-0.05TiO(2)-(0.3 - x)CaO-xSrO (x = 0, 0.01, 0.03, and 0.05). Structural characterization revealed that sodium calcium phosphate is the dominant phase in all the glasses. Degradation studies demonstrated highly linear glass degradation, with Sr-containing glasses degrading at higher rates than the Sr-free glass. Biocompatibility studies using MG63 cells showed that the Sr-containing glasses possess excellent cell attachment and growth, particularly over short periods (~4 days).

KW - Biocompatible Materials

KW - Cell Adhesion

KW - Cell Line

KW - Cell Proliferation

KW - Drug Carriers

KW - Glass

KW - Humans

KW - Ions

KW - Materials Testing

KW - Oxides

KW - Pharmaceutical Vehicles

KW - Strontium

KW - Surface Properties

KW - Titanium

KW - X-Ray Diffraction

U2 - 10.1177/0885328210362125

DO - 10.1177/0885328210362125

M3 - Article

SN - 1530-8022

VL - 25

SP - 877

EP - 893

JO - J Biomater Appl

JF - J Biomater Appl

IS - 8

ER -

Titanium and strontium-doped phosphate glasses as vehicles for strontium ion delivery to cells.

Abstract

Keywords

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