The role of bile acids in carcinogenesis

Philip R. Debruyne; Erik A. Bruyneel; Xuedong Li; Amazia Zimber; Christian Gespach; Marc M. Mareel

doi:10.1016/S0027-5107(01)00195-6

The role of bile acids in carcinogenesis

Philip R. Debruyne
, Erik A. Bruyneel
, Xuedong Li
, Amazia Zimber
, Christian Gespach
, Marc M. Mareel^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Bile acids play a role in colorectal carcinogenesis as evidenced by epidemiological and experimental studies. Some bile acids stimulate growth of normal colonic and adenoma cells, but not of colorectal cancer cells. Moreover, bile acids stimulate invasion of colorectal cancer cells, at least in vitro. One possible mechanism of action is bile acid-induced DNA binding and transactivation of the activator protein-1 (AP-1) by co-operate activation of extracellular signal-regulated kinases (ERKs) and PKC signaling. In the present paper, we review the mechanisms by which bile acids influence carcinogenesis.

Original language	English
Pages (from-to)	359-369
Number of pages	11
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	480-481
DOIs	https://doi.org/10.1016/S0027-5107(01)00195-6
Publication status	Published - 1 Sept 2001
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Molecular Biology
Genetics
Health, Toxicology and Mutagenesis

Keywords

Bile acids
Carcinogenesis
Invasion
Signaling

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10.1016/S0027-5107(01)00195-6

Cite this

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title = "The role of bile acids in carcinogenesis",

abstract = "Bile acids play a role in colorectal carcinogenesis as evidenced by epidemiological and experimental studies. Some bile acids stimulate growth of normal colonic and adenoma cells, but not of colorectal cancer cells. Moreover, bile acids stimulate invasion of colorectal cancer cells, at least in vitro. One possible mechanism of action is bile acid-induced DNA binding and transactivation of the activator protein-1 (AP-1) by co-operate activation of extracellular signal-regulated kinases (ERKs) and PKC signaling. In the present paper, we review the mechanisms by which bile acids influence carcinogenesis.",

keywords = "Bile acids, Carcinogenesis, Invasion, Signaling",

author = "Debruyne, \{Philip R.\} and Bruyneel, \{Erik A.\} and Xuedong Li and Amazia Zimber and Christian Gespach and Mareel, \{Marc M.\}",

year = "2001",

month = sep,

day = "1",

doi = "10.1016/S0027-5107(01)00195-6",

language = "English",

volume = "480-481",

pages = "359--369",

journal = "Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis",

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TY - JOUR

T1 - The role of bile acids in carcinogenesis

AU - Debruyne, Philip R.

AU - Bruyneel, Erik A.

AU - Li, Xuedong

AU - Zimber, Amazia

AU - Gespach, Christian

AU - Mareel, Marc M.

PY - 2001/9/1

Y1 - 2001/9/1

N2 - Bile acids play a role in colorectal carcinogenesis as evidenced by epidemiological and experimental studies. Some bile acids stimulate growth of normal colonic and adenoma cells, but not of colorectal cancer cells. Moreover, bile acids stimulate invasion of colorectal cancer cells, at least in vitro. One possible mechanism of action is bile acid-induced DNA binding and transactivation of the activator protein-1 (AP-1) by co-operate activation of extracellular signal-regulated kinases (ERKs) and PKC signaling. In the present paper, we review the mechanisms by which bile acids influence carcinogenesis.

AB - Bile acids play a role in colorectal carcinogenesis as evidenced by epidemiological and experimental studies. Some bile acids stimulate growth of normal colonic and adenoma cells, but not of colorectal cancer cells. Moreover, bile acids stimulate invasion of colorectal cancer cells, at least in vitro. One possible mechanism of action is bile acid-induced DNA binding and transactivation of the activator protein-1 (AP-1) by co-operate activation of extracellular signal-regulated kinases (ERKs) and PKC signaling. In the present paper, we review the mechanisms by which bile acids influence carcinogenesis.

KW - Bile acids

KW - Carcinogenesis

KW - Invasion

KW - Signaling

UR - https://www.scopus.com/pages/publications/0035451350

U2 - 10.1016/S0027-5107(01)00195-6

DO - 10.1016/S0027-5107(01)00195-6

M3 - Article

C2 - 11506828

AN - SCOPUS:0035451350

SN - 0027-5107

VL - 480-481

SP - 359

EP - 369

JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

JF - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

ER -

The role of bile acids in carcinogenesis

Abstract

UN SDGs

ASJC Scopus subject areas

Keywords

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