Abstract
<jats:sec><jats:title>Introduction</jats:title><jats:p> The aim of this review was to evaluate the impact of preoperative myosteatosis on long-term outcomes following surgery for gastrointestinal malignancy. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> We conducted a systematic search of the electronic information sources, including PubMed MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), CINAHL and AMED. Studies were included if they reported the impact of preoperatively defined myosteatosis, or a similar term, on long-term survival outcomes following surgery for gastrointestinal malignancy. A subgroup analysis was performed for those studies reporting outcomes for colorectal cancer patients only. </jats:p></jats:sec><jats:sec><jats:title>Findings</jats:title><jats:p> Thirty-nine full-text articles were reviewed for inclusion, with 19 being retained after the inclusion criteria were applied. The total number of included patients across all studies was 14,481. Patients with myosteatosis had significantly poorer overall survival, according to univariate (hazard ratio (HR) 1.82, 95% confidence interval (CI) 1.67–1.99) and multivariable (HR 1.66, 95% CI 1.49–1.86) analysis. This was also demonstrated for cancer-specific survival (univariate HR 1.62, 95% CI 1.18–2.22; multivariable HR 1.73, 95% CI 1.48–2.03) and recurrence-free survival (univariate HR 1.28, 95% CI 1.10–1.48; multivariable HR 1.38, 95% CI 1.07–1.77). </jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p> This meta-analysis demonstrates that patients with preoperative myosteatosis have poorer long-term survival outcomes following surgery for gastrointestinal malignancy. Therefore, myosteatosis should be used for preoperative optimisation and as a prognostic tool before surgery. More standardised definitions of myosteatosis and further cohort studies of patients with non-colorectal malignancies are required. </jats:p></jats:sec>
Original language | English |
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Pages (from-to) | 203-211 |
Number of pages | 0 |
Journal | The Annals of The Royal College of Surgeons of England |
Volume | 105 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2023 |