Abstract
Although the chemoreceptor response to acute changes in [K+]art has been well documented, description of ventilatory effects is limited to the observation that injections oroduce a transient hyperventilation which is synchronous with the increase in chemoreceptor discharge and abolished by chemodenervation. I have investigated the interaction of K* with changes in FICO2, and FI02, both of which are known to influence ventilation.
During exercise there are marked changes in heart rate and blood pressure. | have examined the possibility that transient hyperkalaemia may contribute to these changes.
In order to understand the nature of the hyperkalaemic response to exercise better, | have investigated ts magnitude and character during different types of exercise and correlated the changes in [K+]art with changes in ventilation.
Extra-renal regulation of [K+] has previously been described at rest. I have undertaken experiments to clarify its role in disposal of K+1oads generated during exercise and investigated bone as a possible 'sink’ for
K+
During exercise there are marked changes in heart rate and blood pressure. | have examined the possibility that transient hyperkalaemia may contribute to these changes.
In order to understand the nature of the hyperkalaemic response to exercise better, | have investigated ts magnitude and character during different types of exercise and correlated the changes in [K+]art with changes in ventilation.
Extra-renal regulation of [K+] has previously been described at rest. I have undertaken experiments to clarify its role in disposal of K+1oads generated during exercise and investigated bone as a possible 'sink’ for
K+
| Original language | English |
|---|---|
| Type | Previously Awarded MD |
| Publication status | Published - 1 Jun 1989 |