The hyper-transmissible SARS-CoV-2 Omicron variant exhibits significant antigenic change, vaccine escape and a switch in cell entry mechanism

Brian J. Willett; Joe Grove; Oscar A. MacLean; Craig Wilkie; Nicola Logan; Giuditta De Lorenzo; Wilhelm Furnon; Sam Scott; Maria Manali; Agnieszka Szemiel; Shirin Ashraf; Elen Vink; William T. Harvey; Chris Davis; Richard Orton; Joseph Hughes; Poppy Holland; Vanessa Silva; David Pascall; Kathryn Puxty; Ana da Silva Filipe; Gonzalo Yebra; Sharif Shaaban; Matthew T. G. Holden; Rute Maria Pinto; Rory Gunson; Kate Templeton; Pablo R. Murcia; Arvind H. Patel; John Haughney; David L. Robertson; Massimo Palmarini; Surajit Ray; Emma C. Thomson; COVID-19 Genomics UK (COG-UK) Consortium; Anna Mantzouratou

doi:10.1101/2022.01.03.21268111

The hyper-transmissible SARS-CoV-2 Omicron variant exhibits significant antigenic change, vaccine escape and a switch in cell entry mechanism

Brian J. Willett
, Joe Grove
, Oscar A. MacLean
, Craig Wilkie
, Nicola Logan
, Giuditta De Lorenzo
, Wilhelm Furnon
, Sam Scott
, Maria Manali
, Agnieszka Szemiel
, Shirin Ashraf
, Elen Vink
, William T. Harvey
, Chris Davis
, Richard Orton
, Joseph Hughes
, Poppy Holland
, Vanessa Silva
, David Pascall
, Kathryn Puxty

Ana da Silva Filipe, Gonzalo Yebra, Sharif Shaaban, Matthew T. G. Holden, Rute Maria Pinto, Rory Gunson, Kate Templeton, Pablo R. Murcia, Arvind H. Patel, John Haughney, David L. Robertson, Massimo Palmarini, Surajit Ray, Emma C. Thomson, COVID-19 Genomics UK (COG-UK) Consortium, Anna Mantzouratou

Bournemouth University

Research output: Working paper / Preprint › Preprint

Original language	English
Publisher	MedRxiv
DOIs	https://doi.org/10.1101/2022.01.03.21268111
Publication status	Published - 26 Jan 2022
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1101/2022.01.03.21268111

http://medrxiv.org/lookup/doi/10.1101/2022.01.03.21268111

Cite this

Willett, B. J., Grove, J., MacLean, O. A., Wilkie, C., Logan, N., Lorenzo, G. D., Furnon, W., Scott, S., Manali, M., Szemiel, A., Ashraf, S., Vink, E., Harvey, W. T., Davis, C., Orton, R., Hughes, J., Holland, P., Silva, V., Pascall, D., ... Mantzouratou, A. (2022). The hyper-transmissible SARS-CoV-2 Omicron variant exhibits significant antigenic change, vaccine escape and a switch in cell entry mechanism. MedRxiv. https://doi.org/10.1101/2022.01.03.21268111

@techreport{773e9f3ece2f468baf02694f1fed12ff,

title = "The hyper-transmissible SARS-CoV-2 Omicron variant exhibits significant antigenic change, vaccine escape and a switch in cell entry mechanism",

author = "Willett, \{Brian J.\} and Joe Grove and MacLean, \{Oscar A.\} and Craig Wilkie and Nicola Logan and Lorenzo, \{Giuditta De\} and Wilhelm Furnon and Sam Scott and Maria Manali and Agnieszka Szemiel and Shirin Ashraf and Elen Vink and Harvey, \{William T.\} and Chris Davis and Richard Orton and Joseph Hughes and Poppy Holland and Vanessa Silva and David Pascall and Kathryn Puxty and \{da Silva Filipe\}, Ana and Gonzalo Yebra and Sharif Shaaban and Holden, \{Matthew T. G.\} and Pinto, \{Rute Maria\} and Rory Gunson and Kate Templeton and Murcia, \{Pablo R.\} and Patel, \{Arvind H.\} and John Haughney and Robertson, \{David L.\} and Massimo Palmarini and Surajit Ray and Thomson, \{Emma C.\} and Consortium, \{COVID-19 Genomics UK (COG-UK)\} and Anna Mantzouratou",

year = "2022",

month = jan,

day = "26",

doi = "10.1101/2022.01.03.21268111",

language = "English",

publisher = "MedRxiv",

type = "WorkingPaper",

institution = "MedRxiv",

}

Willett, BJ, Grove, J, MacLean, OA, Wilkie, C, Logan, N, Lorenzo, GD, Furnon, W, Scott, S, Manali, M, Szemiel, A, Ashraf, S, Vink, E, Harvey, WT, Davis, C, Orton, R, Hughes, J, Holland, P, Silva, V, Pascall, D, Puxty, K, da Silva Filipe, A, Yebra, G, Shaaban, S, Holden, MTG, Pinto, RM, Gunson, R, Templeton, K, Murcia, PR, Patel, AH, Haughney, J, Robertson, DL, Palmarini, M, Ray, S, Thomson, EC, Consortium, COVIDGUK & Mantzouratou, A 2022 'The hyper-transmissible SARS-CoV-2 Omicron variant exhibits significant antigenic change, vaccine escape and a switch in cell entry mechanism' MedRxiv. https://doi.org/10.1101/2022.01.03.21268111

TY - UNPB

T1 - The hyper-transmissible SARS-CoV-2 Omicron variant exhibits significant antigenic change, vaccine escape and a switch in cell entry mechanism

AU - Willett, Brian J.

AU - Grove, Joe

AU - MacLean, Oscar A.

AU - Wilkie, Craig

AU - Logan, Nicola

AU - Lorenzo, Giuditta De

AU - Furnon, Wilhelm

AU - Scott, Sam

AU - Manali, Maria

AU - Szemiel, Agnieszka

AU - Ashraf, Shirin

AU - Vink, Elen

AU - Harvey, William T.

AU - Davis, Chris

AU - Orton, Richard

AU - Hughes, Joseph

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AU - Yebra, Gonzalo

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AU - Gunson, Rory

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AU - Murcia, Pablo R.

AU - Patel, Arvind H.

AU - Haughney, John

AU - Robertson, David L.

AU - Palmarini, Massimo

AU - Ray, Surajit

AU - Thomson, Emma C.

AU - Consortium, COVID-19 Genomics UK (COG-UK)

AU - Mantzouratou, Anna

PY - 2022/1/26

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U2 - 10.1101/2022.01.03.21268111

DO - 10.1101/2022.01.03.21268111

M3 - Preprint

BT - The hyper-transmissible SARS-CoV-2 Omicron variant exhibits significant antigenic change, vaccine escape and a switch in cell entry mechanism

PB - MedRxiv

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