The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-Synuclein

Riccardo Porcari; Christos Proukakis; Christopher A. Waudby; Benedetta Bolognesi; P. Patrizia Mangione; Jack F.S. Paton; Stephen Mullin; Lisa D. Cabrita; Amanda Penco; Annalisa Relini; Guglielmo Verona; Michele Vendruscolo; Monica Stoppini; Gian Gaetano Tartaglia; Carlo Camilloni; John Christodoulou; Anthony H.V. Schapira; Vittorio Bellotti

doi:10.1074/jbc.m114.610527

The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-Synuclein

Riccardo Porcari
, Christos Proukakis
, Christopher A. Waudby
, Benedetta Bolognesi
, P. Patrizia Mangione
, Jack F.S. Paton
, Stephen Mullin
, Lisa D. Cabrita
, Amanda Penco
, Annalisa Relini
, Guglielmo Verona
, Michele Vendruscolo
, Monica Stoppini
, Gian Gaetano Tartaglia
, Carlo Camilloni
, John Christodoulou^*
, Anthony H.V. Schapira
, Vittorio Bellotti

^*Corresponding author for this work

Peninsula Medical School

Research output: Contribution to journal › Article › peer-review

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Original language	English
Pages (from-to)	2395-2404
Number of pages	0
Journal	Journal of Biological Chemistry
Volume	290
Issue number	4
DOIs	https://doi.org/10.1074/jbc.m114.610527
Publication status	Published - Jan 2015

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10.1074/jbc.m114.610527

The H50Q mutation induces a 10-fold decrease in the solubility of -synucleinLicence: CC BY-NC

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Porcari, R., Proukakis, C., Waudby, C. A., Bolognesi, B., Mangione, P. P., Paton, J. F. S., Mullin, S., Cabrita, L. D., Penco, A., Relini, A., Verona, G., Vendruscolo, M., Stoppini, M., Tartaglia, G. G., Camilloni, C., Christodoulou, J., Schapira, A. H. V., & Bellotti, V. (2015). The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-Synuclein. Journal of Biological Chemistry, 290(4), 2395-2404. https://doi.org/10.1074/jbc.m114.610527

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title = "The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-Synuclein",

author = "Riccardo Porcari and Christos Proukakis and Waudby, \{Christopher A.\} and Benedetta Bolognesi and Mangione, \{P. Patrizia\} and Paton, \{Jack F.S.\} and Stephen Mullin and Cabrita, \{Lisa D.\} and Amanda Penco and Annalisa Relini and Guglielmo Verona and Michele Vendruscolo and Monica Stoppini and Tartaglia, \{Gian Gaetano\} and Carlo Camilloni and John Christodoulou and Schapira, \{Anthony H.V.\} and Vittorio Bellotti",

year = "2015",

month = jan,

doi = "10.1074/jbc.m114.610527",

language = "English",

volume = "290",

pages = "2395--2404",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

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}

Porcari, R, Proukakis, C, Waudby, CA, Bolognesi, B, Mangione, PP, Paton, JFS, Mullin, S, Cabrita, LD, Penco, A, Relini, A, Verona, G, Vendruscolo, M, Stoppini, M, Tartaglia, GG, Camilloni, C, Christodoulou, J, Schapira, AHV & Bellotti, V 2015, 'The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-Synuclein', Journal of Biological Chemistry, vol. 290, no. 4, pp. 2395-2404. https://doi.org/10.1074/jbc.m114.610527

TY - JOUR

T1 - The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-Synuclein

AU - Porcari, Riccardo

AU - Proukakis, Christos

AU - Waudby, Christopher A.

AU - Bolognesi, Benedetta

AU - Mangione, P. Patrizia

AU - Paton, Jack F.S.

AU - Mullin, Stephen

AU - Cabrita, Lisa D.

AU - Penco, Amanda

AU - Relini, Annalisa

AU - Verona, Guglielmo

AU - Vendruscolo, Michele

AU - Stoppini, Monica

AU - Tartaglia, Gian Gaetano

AU - Camilloni, Carlo

AU - Christodoulou, John

AU - Schapira, Anthony H.V.

AU - Bellotti, Vittorio

PY - 2015/1

Y1 - 2015/1

UR - https://pearl.plymouth.ac.uk/pms-research/902/

U2 - 10.1074/jbc.m114.610527

DO - 10.1074/jbc.m114.610527

M3 - Article

SN - 0021-9258

VL - 290

SP - 2395

EP - 2404

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 4

ER -

The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-Synuclein

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