The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-Synuclein

Riccardo Porcari; Christos Proukakis; Christopher A. Waudby; Benedetta Bolognesi; P. Patrizia Mangione; Jack F.S. Paton; Stephen Mullin; Lisa D. Cabrita; Amanda Penco; Annalisa Relini; Guglielmo Verona; Michele Vendruscolo; Monica Stoppini; Gian Gaetano Tartaglia; Carlo Camilloni; John Christodoulou; Anthony H.V. Schapira; Vittorio Bellotti

doi:10.1074/jbc.m114.610527

The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-Synuclein

Riccardo Porcari, Christos Proukakis, Christopher A. Waudby, Benedetta Bolognesi, P. Patrizia Mangione, Jack F.S. Paton, Stephen Mullin, Lisa D. Cabrita, Amanda Penco, Annalisa Relini, Guglielmo Verona, Michele Vendruscolo, Monica Stoppini, Gian Gaetano Tartaglia, Carlo Camilloni, John Christodoulou^*, Anthony H.V. Schapira, Vittorio Bellotti

^*Corresponding author for this work

Peninsula Medical School

Research output: Contribution to journal › Article › peer-review

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Original language	English
Pages (from-to)	2395-2404
Number of pages	0
Journal	Journal of Biological Chemistry
Volume	290
Issue number	4
DOIs	https://doi.org/10.1074/jbc.m114.610527
Publication status	Published - Jan 2015

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The H50Q mutation induces a 10-fold decrease in the solubility of -synucleinLicence: CC BY-NC

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Porcari, R., Proukakis, C., Waudby, C. A., Bolognesi, B., Mangione, P. P., Paton, J. F. S., Mullin, S., Cabrita, L. D., Penco, A., Relini, A., Verona, G., Vendruscolo, M., Stoppini, M., Tartaglia, G. G., Camilloni, C., Christodoulou, J., Schapira, A. H. V., & Bellotti, V. (2015). The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-Synuclein. Journal of Biological Chemistry, 290(4), 2395-2404. https://doi.org/10.1074/jbc.m114.610527

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title = "The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-Synuclein",

author = "Riccardo Porcari and Christos Proukakis and Waudby, {Christopher A.} and Benedetta Bolognesi and Mangione, {P. Patrizia} and Paton, {Jack F.S.} and Stephen Mullin and Cabrita, {Lisa D.} and Amanda Penco and Annalisa Relini and Guglielmo Verona and Michele Vendruscolo and Monica Stoppini and Tartaglia, {Gian Gaetano} and Carlo Camilloni and John Christodoulou and Schapira, {Anthony H.V.} and Vittorio Bellotti",

year = "2015",

month = jan,

doi = "10.1074/jbc.m114.610527",

language = "English",

volume = "290",

pages = "2395--2404",

journal = "Journal of Biological Chemistry",

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Porcari, R, Proukakis, C, Waudby, CA, Bolognesi, B, Mangione, PP, Paton, JFS, Mullin, S, Cabrita, LD, Penco, A, Relini, A, Verona, G, Vendruscolo, M, Stoppini, M, Tartaglia, GG, Camilloni, C, Christodoulou, J, Schapira, AHV & Bellotti, V 2015, 'The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-Synuclein', Journal of Biological Chemistry, vol. 290, no. 4, pp. 2395-2404. https://doi.org/10.1074/jbc.m114.610527

TY - JOUR

T1 - The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-Synuclein

AU - Porcari, Riccardo

AU - Proukakis, Christos

AU - Waudby, Christopher A.

AU - Bolognesi, Benedetta

AU - Mangione, P. Patrizia

AU - Paton, Jack F.S.

AU - Mullin, Stephen

AU - Cabrita, Lisa D.

AU - Penco, Amanda

AU - Relini, Annalisa

AU - Verona, Guglielmo

AU - Vendruscolo, Michele

AU - Stoppini, Monica

AU - Tartaglia, Gian Gaetano

AU - Camilloni, Carlo

AU - Christodoulou, John

AU - Schapira, Anthony H.V.

AU - Bellotti, Vittorio

PY - 2015/1

Y1 - 2015/1

UR - https://pearl.plymouth.ac.uk/context/pms-research/article/1901/viewcontent/The_20H50Q_20mutation_20induces_20a_2010_fold_20decrease_20in_20the_20solubility_20of_20_20_synuclein.pdf

U2 - 10.1074/jbc.m114.610527

DO - 10.1074/jbc.m114.610527

M3 - Article

SN - 0021-9258

VL - 290

SP - 2395

EP - 2404

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 4

ER -

The H50Q Mutation Induces a 10-fold Decrease in the Solubility of α-Synuclein

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