The Genetics of Parkinson’s Disease and Implications for Clinical Practice

Jacob Oliver Day; Stephen Mullin

doi:10.3390/genes12071006

The Genetics of Parkinson’s Disease and Implications for Clinical Practice

Jacob Oliver Day, Stephen Mullin^*

^*Corresponding author for this work

Peninsula Medical School

University College London

Research output: Contribution to journal › Article › peer-review

15 Downloads (Pure)

Abstract

The genetic landscape of Parkinson’s disease (PD) is characterised by rare high penetrance pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a significant minority in PD cases and high frequency, low penetrance variants, which contribute a small increase of the risk of developing sporadic PD. This knowledge has the potential to have a major impact in the clinical care of people with PD. We summarise these genetic influences and discuss the implications for therapeutics and clinical trial design.

Original language	English
Pages (from-to)	1006-1006
Number of pages	0
Journal	Genes
Volume	12
Issue number	7
Early online date	30 Jun 2021
DOIs	https://doi.org/10.3390/genes12071006
Publication status	Published - 30 Jun 2021

Access to Document

10.3390/genes12071006

Genes-12-01006 - Genetics of Parkinson s review - June 2021Licence: CC BY

Cite this

@article{cc5d85e9ae6848d5aa1549749cea754b,

title = "The Genetics of Parkinson{\textquoteright}s Disease and Implications for Clinical Practice",

abstract = "The genetic landscape of Parkinson{\textquoteright}s disease (PD) is characterised by rare high penetrance pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a significant minority in PD cases and high frequency, low penetrance variants, which contribute a small increase of the risk of developing sporadic PD. This knowledge has the potential to have a major impact in the clinical care of people with PD. We summarise these genetic influences and discuss the implications for therapeutics and clinical trial design.",

author = "Day, {Jacob Oliver} and Stephen Mullin",

year = "2021",

month = jun,

day = "30",

doi = "10.3390/genes12071006",

language = "English",

volume = "12",

pages = "1006--1006",

journal = "Genes",

issn = "2073-4425",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "7",

}

TY - JOUR

T1 - The Genetics of Parkinson’s Disease and Implications for Clinical Practice

AU - Day, Jacob Oliver

AU - Mullin, Stephen

PY - 2021/6/30

Y1 - 2021/6/30

N2 - The genetic landscape of Parkinson’s disease (PD) is characterised by rare high penetrance pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a significant minority in PD cases and high frequency, low penetrance variants, which contribute a small increase of the risk of developing sporadic PD. This knowledge has the potential to have a major impact in the clinical care of people with PD. We summarise these genetic influences and discuss the implications for therapeutics and clinical trial design.

AB - The genetic landscape of Parkinson’s disease (PD) is characterised by rare high penetrance pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a significant minority in PD cases and high frequency, low penetrance variants, which contribute a small increase of the risk of developing sporadic PD. This knowledge has the potential to have a major impact in the clinical care of people with PD. We summarise these genetic influences and discuss the implications for therapeutics and clinical trial design.

U2 - 10.3390/genes12071006

DO - 10.3390/genes12071006

M3 - Article

SN - 2073-4425

VL - 12

SP - 1006

EP - 1006

JO - Genes

JF - Genes

IS - 7

ER -

The Genetics of Parkinson’s Disease and Implications for Clinical Practice

Abstract

Access to Document

Fingerprint

Cite this