The effect of temperature on di(2-ethylhexyl) phthalate leaching from PVC infusion sets exposed to lipid emulsions

R. J. Rose, M. J. Priston, A. E. Rigby-Jones, J. R. Sneyd*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Poly vinyl chloride (PVC) infusion equipment contains substantial amounts of the plasticiser di(2-ethylhexyl) phthalate (DEHP). We determined the amount of DEHP leached from Mediplus Dual TIVA(®) Infusion sets, into lipid and non-lipid infusates. Two propofol admixtures (Diprivan(®) 1%, Propoven(®) 1%), Intralipid(®) 10% and 0.9% saline were evaluated as infusates. Solutions were infused through TIVA sets at 12 ml.h(-1) for 6 h at 24, 32 and 37 °C. In addition, TIVA sets were filled with 2 ml infusates, sealed and incubated at 24 and 37 °C for 6 h. Di(2-ethylhexyl) phthalate was detected in all lipid infusates after dynamic infusion and static contact, and in 0.9% saline after dynamic infusion at 37 °C. At 32 and 37 °C, the quantity of di(2-ethylhexyl) phthalate leaching into the lipid infusates may exceed the recommended maximum exposure amount set by the European Union for DEHP of 20-48 μg.kg(-1) day(-1) if lipid based infusates are used for sedation or intravenous feeding of infants or neonates.
Original languageEnglish
Pages (from-to)514-520
Number of pages7
JournalAnaesthesia
Volume67
Issue number5
DOIs
Publication statusPublished - May 2012

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Keywords

  • Analysis of Variance
  • Chromatography
  • Diethylhexyl Phthalate
  • Drug Contamination
  • Emulsions
  • Equipment Contamination
  • Fat Emulsions
  • Intravenous
  • Hot Temperature
  • Infusions
  • Maximum Allowable Concentration
  • Phospholipids
  • Plasticizers
  • Polyvinyl Chloride
  • Propofol
  • Sodium Chloride
  • Soybean Oil
  • Temperature

Fingerprint

Dive into the research topics of 'The effect of temperature on di(2-ethylhexyl) phthalate leaching from PVC infusion sets exposed to lipid emulsions'. Together they form a unique fingerprint.

Cite this