Abstract
Poly vinyl chloride (PVC) infusion equipment contains substantial amounts of the plasticiser di(2-ethylhexyl) phthalate (DEHP). We determined the amount of DEHP leached from Mediplus Dual TIVA(®) Infusion sets, into lipid and non-lipid infusates. Two propofol admixtures (Diprivan(®) 1%, Propoven(®) 1%), Intralipid(®) 10% and 0.9% saline were evaluated as infusates. Solutions were infused through TIVA sets at 12 ml.h(-1) for 6 h at 24, 32 and 37 °C. In addition, TIVA sets were filled with 2 ml infusates, sealed and incubated at 24 and 37 °C for 6 h. Di(2-ethylhexyl) phthalate was detected in all lipid infusates after dynamic infusion and static contact, and in 0.9% saline after dynamic infusion at 37 °C. At 32 and 37 °C, the quantity of di(2-ethylhexyl) phthalate leaching into the lipid infusates may exceed the recommended maximum exposure amount set by the European Union for DEHP of 20-48 μg.kg(-1) day(-1) if lipid based infusates are used for sedation or intravenous feeding of infants or neonates.
Original language | English |
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Pages (from-to) | 514-520 |
Number of pages | 7 |
Journal | Anaesthesia |
Volume | 67 |
Issue number | 5 |
DOIs | |
Publication status | Published - May 2012 |
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
Keywords
- Analysis of Variance
- Chromatography
- Diethylhexyl Phthalate
- Drug Contamination
- Emulsions
- Equipment Contamination
- Fat Emulsions
- Intravenous
- Hot Temperature
- Infusions
- Maximum Allowable Concentration
- Phospholipids
- Plasticizers
- Polyvinyl Chloride
- Propofol
- Sodium Chloride
- Soybean Oil
- Temperature