Abstract
<jats:p>Sickle cell disease compromises muscle O<jats:sub>2</jats:sub>delivery resulting in exercise intolerance. Dietary nitrate supplementation increases skeletal muscle blood flow during exercise and may improve exercise capacity in a mouse model of sickle cell disease. We investigated the effects of dietary nitrate supplementation on exercise tolerance in a mouse model of sickle cell disease using the treadmill speed-duration relationship (critical speed). Mice with sickle cell disease provided with a dietary nitrate supplement had a critical speed not significantly different from healthy wild-type mice.</jats:p>
Original language | English |
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Pages (from-to) | 474-482 |
Number of pages | 0 |
Journal | Journal of Applied Physiology |
Volume | 129 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Sept 2020 |