The effect of dietary nitrate supplementation on the speed-duration relationship in mice with sickle cell disease

SK Ferguson, KM Redinius, JW Harral, DI Pak, DC Swindle, DM Hirai, JR Blackwell, AM Jones, KR Stenmark, PW Buehler, DC Irwin

Research output: Contribution to journalArticlepeer-review

Abstract

<jats:p>Sickle cell disease compromises muscle O<jats:sub>2</jats:sub>delivery resulting in exercise intolerance. Dietary nitrate supplementation increases skeletal muscle blood flow during exercise and may improve exercise capacity in a mouse model of sickle cell disease. We investigated the effects of dietary nitrate supplementation on exercise tolerance in a mouse model of sickle cell disease using the treadmill speed-duration relationship (critical speed). Mice with sickle cell disease provided with a dietary nitrate supplement had a critical speed not significantly different from healthy wild-type mice.</jats:p>
Original languageEnglish
Pages (from-to)474-482
Number of pages0
JournalJournal of Applied Physiology
Volume129
Issue number3
DOIs
Publication statusPublished - 1 Sept 2020

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