The contribution of ischaemia and deformation to the conduction block generated by compression of the cat sciatic nerve

R. Fern*, PJ Harrison

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

<jats:p>The pattern of conduction block induced in cat peripheral nerve by compression has been investigated electrophysiologically by recording unitary action potentials. A degree of compression, associated with chronic compression disorders in man, was applied to the cat sciatic nerve and resulted in a conduction block typified by early failure of the slow conducting myelinated axons. By contrast, a greater degree of compression, a degree more likely to result in acute compression lesions, produced a different pattern of effect, inducing early conduction failure in the fast conducting myelinated axons. These results are related to earlier studies which have shown that nerve deformation during compression has a differential action upon fast myelinated axons, while nerve ischaemia has a differential action upon slow myelinated axons.</jats:p>
Original languageEnglish
Pages (from-to)583-592
Number of pages0
JournalExperimental Physiology
Volume79
Issue number4
DOIs
Publication statusPublished - Jul 1994

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