Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1.

Natalie Rezai-Zadeh; Xiaohong Zhang; Fares Namour; Gyorgy Fejer; Yu Der Wen; Ya Li Yao; Ildiko Gyory; Kenneth Wright; Edward Seto

doi:10.1101/gad.1068003

Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1.

Natalie Rezai-Zadeh, Xiaohong Zhang, Fares Namour, Gyorgy Fejer, Yu Der Wen, Ya Li Yao, Ildiko Gyory, Kenneth Wright, Edward Seto^*

^*Corresponding author for this work

School of Biomedical Sciences

University of South Florida

Research output: Contribution to journal › Article › peer-review

Abstract

Methylation of specific residues within the N-terminal histone tails plays a critical role in regulating eukaryotic gene expression. Although great advances have been made toward identifying histone methyltransferases (HMTs) and elucidating the consequences of histone methylation, little is known about the recruitment of HMTs to regulatory regions of chromatin. Here we report that the sequence-specific DNA-binding transcription factor Yin Yang 1 (YY1) binds to and recruits the histone H4 (Arg 3)-specific methyltransferase, PRMT1, to a YY1-activated promoter. Our data confirm that histone methylation does not occur randomly but rather is a targeted event and provides one mechanism by which HMTs can be recruited to chromatin to activate gene expression.

Original language	English
Pages (from-to)	1019-1029
Number of pages	0
Journal	Genes Dev
Volume	17
Issue number	8
DOIs	https://doi.org/10.1101/gad.1068003
Publication status	Published - 15 Apr 2003

Keywords

Amino Acid Sequence
Animals
Arginine
Binding Sites
Blotting
Western
Chromatin
DNA Primers
DNA-Binding Proteins
Electrophoretic Mobility Shift Assay
Erythroid-Specific DNA-Binding Factors
Gene Expression Regulation
Glutathione Transferase
Histones
Luciferases
Methylation
Molecular Sequence Data
Nuclear Factor 90 Proteins
Phosphoproteins
Promoter Regions
Genetic
Protein-Arginine N-Methyltransferases
RNA-Binding Proteins
Regulatory Sequences
Nucleic Acid
Repressor Proteins
Sequence Deletion
Sequence Homology
Amino Acid
Transcription Factors
Transcription
Transcriptional Activation
Transfection
YY1 Transcription Factor
Zinc Fingers

Access to Document

10.1101/gad.1068003

Cite this

@article{25f0136a71254feca3c0071e5acb71c3,

title = "Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1.",

abstract = "Methylation of specific residues within the N-terminal histone tails plays a critical role in regulating eukaryotic gene expression. Although great advances have been made toward identifying histone methyltransferases (HMTs) and elucidating the consequences of histone methylation, little is known about the recruitment of HMTs to regulatory regions of chromatin. Here we report that the sequence-specific DNA-binding transcription factor Yin Yang 1 (YY1) binds to and recruits the histone H4 (Arg 3)-specific methyltransferase, PRMT1, to a YY1-activated promoter. Our data confirm that histone methylation does not occur randomly but rather is a targeted event and provides one mechanism by which HMTs can be recruited to chromatin to activate gene expression.",

keywords = "Amino Acid Sequence, Animals, Arginine, Binding Sites, Blotting, Western, Chromatin, DNA Primers, DNA-Binding Proteins, Electrophoretic Mobility Shift Assay, Erythroid-Specific DNA-Binding Factors, Gene Expression Regulation, Glutathione Transferase, Histones, Luciferases, Methylation, Molecular Sequence Data, Nuclear Factor 90 Proteins, Phosphoproteins, Promoter Regions, Genetic, Protein-Arginine N-Methyltransferases, RNA-Binding Proteins, Regulatory Sequences, Nucleic Acid, Repressor Proteins, Sequence Deletion, Sequence Homology, Amino Acid, Transcription Factors, Transcription, Transcriptional Activation, Transfection, YY1 Transcription Factor, Zinc Fingers",

author = "Natalie Rezai-Zadeh and Xiaohong Zhang and Fares Namour and Gyorgy Fejer and Wen, {Yu Der} and Yao, {Ya Li} and Ildiko Gyory and Kenneth Wright and Edward Seto",

year = "2003",

month = apr,

day = "15",

doi = "10.1101/gad.1068003",

language = "English",

volume = "17",

pages = "1019--1029",

journal = "Genes Dev",

issn = "0890-9369",

number = "8",

}

TY - JOUR

T1 - Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1.

AU - Rezai-Zadeh, Natalie

AU - Zhang, Xiaohong

AU - Namour, Fares

AU - Fejer, Gyorgy

AU - Wen, Yu Der

AU - Yao, Ya Li

AU - Gyory, Ildiko

AU - Wright, Kenneth

AU - Seto, Edward

PY - 2003/4/15

Y1 - 2003/4/15

N2 - Methylation of specific residues within the N-terminal histone tails plays a critical role in regulating eukaryotic gene expression. Although great advances have been made toward identifying histone methyltransferases (HMTs) and elucidating the consequences of histone methylation, little is known about the recruitment of HMTs to regulatory regions of chromatin. Here we report that the sequence-specific DNA-binding transcription factor Yin Yang 1 (YY1) binds to and recruits the histone H4 (Arg 3)-specific methyltransferase, PRMT1, to a YY1-activated promoter. Our data confirm that histone methylation does not occur randomly but rather is a targeted event and provides one mechanism by which HMTs can be recruited to chromatin to activate gene expression.

AB - Methylation of specific residues within the N-terminal histone tails plays a critical role in regulating eukaryotic gene expression. Although great advances have been made toward identifying histone methyltransferases (HMTs) and elucidating the consequences of histone methylation, little is known about the recruitment of HMTs to regulatory regions of chromatin. Here we report that the sequence-specific DNA-binding transcription factor Yin Yang 1 (YY1) binds to and recruits the histone H4 (Arg 3)-specific methyltransferase, PRMT1, to a YY1-activated promoter. Our data confirm that histone methylation does not occur randomly but rather is a targeted event and provides one mechanism by which HMTs can be recruited to chromatin to activate gene expression.

KW - Amino Acid Sequence

KW - Animals

KW - Arginine

KW - Binding Sites

KW - Blotting

KW - Western

KW - Chromatin

KW - DNA Primers

KW - DNA-Binding Proteins

KW - Electrophoretic Mobility Shift Assay

KW - Erythroid-Specific DNA-Binding Factors

KW - Gene Expression Regulation

KW - Glutathione Transferase

KW - Histones

KW - Luciferases

KW - Methylation

KW - Molecular Sequence Data

KW - Nuclear Factor 90 Proteins

KW - Phosphoproteins

KW - Promoter Regions

KW - Genetic

KW - Protein-Arginine N-Methyltransferases

KW - RNA-Binding Proteins

KW - Regulatory Sequences

KW - Nucleic Acid

KW - Repressor Proteins

KW - Sequence Deletion

KW - Sequence Homology

KW - Amino Acid

KW - Transcription Factors

KW - Transcription

KW - Transcriptional Activation

KW - Transfection

KW - YY1 Transcription Factor

KW - Zinc Fingers

U2 - 10.1101/gad.1068003

DO - 10.1101/gad.1068003

M3 - Article

SN - 0890-9369

VL - 17

SP - 1019

EP - 1029

JO - Genes Dev

JF - Genes Dev

IS - 8

ER -

Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1.

Abstract

Keywords

Access to Document

Fingerprint

Cite this