Stability of an epidural analgesic admixture containing epinephrine, fentanyl and bupivacaine

Melanie J. Priston; J. M. Hughes; M. Santillo; I. W. Christie

doi:10.1111/j.1365-2044.2004.03803.x

Stability of an epidural analgesic admixture containing epinephrine, fentanyl and bupivacaine

Melanie J. Priston^*, J. M. Hughes, M. Santillo, I. W. Christie

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The addition of epinephrine to solutions containing fentanyl and bupivacaine for epidural infusion has been shown to improve the quality of analgesia. However, this admixture is not available commercially in the United Kingdom. Moreover, stability data applicable to UK practice for this admixture are limited. This study investigated the stability of fentanyl 2 μg.ml^-1 plus bupivacaine 1 mg.ml^-1 in PVC bags with and without epinephrine 2 μg.ml^-1 over a period of 184 days both at room temperature and at 4 °C. All infusions were found to be stable over the study period (> 90% remaining) using stability-indicating High Performance Liquid Chromatography (HPLC) methods, with no changes in physical appearance or pH (range 4.5-4.2). The infusions were prepared using standard pharmaceutica products, so facilitating the batch preparation of epinephrine, fentanyl and bupivacaine epidural solutions by hospital pharmacy departments.

Original language	English
Pages (from-to)	979-983
Number of pages	5
Journal	Anaesthesia
Volume	59
Issue number	10
DOIs	https://doi.org/10.1111/j.1365-2044.2004.03803.x
Publication status	Published - Oct 2004

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

Keywords

Analgesia, epidural
Analgesics; fentanyl
Drug stability
Local anaesthetics; bupivacaine

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10.1111/j.1365-2044.2004.03803.x

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title = "Stability of an epidural analgesic admixture containing epinephrine, fentanyl and bupivacaine",

abstract = "The addition of epinephrine to solutions containing fentanyl and bupivacaine for epidural infusion has been shown to improve the quality of analgesia. However, this admixture is not available commercially in the United Kingdom. Moreover, stability data applicable to UK practice for this admixture are limited. This study investigated the stability of fentanyl 2 μg.ml-1 plus bupivacaine 1 mg.ml-1 in PVC bags with and without epinephrine 2 μg.ml-1 over a period of 184 days both at room temperature and at 4 °C. All infusions were found to be stable over the study period (> 90% remaining) using stability-indicating High Performance Liquid Chromatography (HPLC) methods, with no changes in physical appearance or pH (range 4.5-4.2). The infusions were prepared using standard pharmaceutica products, so facilitating the batch preparation of epinephrine, fentanyl and bupivacaine epidural solutions by hospital pharmacy departments.",

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AU - Christie, I. W.

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Stability of an epidural analgesic admixture containing epinephrine, fentanyl and bupivacaine

Abstract

ASJC Scopus subject areas

Keywords

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