Recurrent Chronic HEV in Severe Combined Immunodeficiency

Prebashan Moodley; Andrew F. Whyte; Ashwin Dhanda

doi:10.1007/s10875-021-00999-4

Recurrent Chronic HEV in Severe Combined Immunodeficiency

Prebashan Moodley^*
, Andrew F. Whyte
, Ashwin Dhanda

^*Corresponding author for this work

Peninsula Medical School

University Hospitals Plymouth NHS Trust

Research output: Contribution to journal › Article › peer-review

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Abstract

Severe combined immunodeficiency (SCID) is a group of genetic disorders characterized by significant impairment of T cell differentiation, with or without abnormal B and NK cell differentiation. Without hematopoietic stem cell transplant (HSCT), the condition usually leads to an early death, typically due to infections. The most frequent genetic cause of SCID affects the common gamma chain, necessary for cytokine signaling. A similar phenotype is observed with mutations in the Janus-associated kinase 3 (JAK3) gene, the immediate downstream signaling molecule

Original language	English
Pages (from-to)	1103-1105
Number of pages	0
Journal	Journal of Clinical Immunology
Volume	41
Issue number	5
Early online date	22 Feb 2021
DOIs	https://doi.org/10.1007/s10875-021-00999-4
Publication status	Published - 22 Feb 2021

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1007/s10875-021-00999-4

Moodley J Clin Immunol 2021 HEV case report for depositAccepted author manuscript, 160 KBLicence: CC BY-SA

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title = "Recurrent Chronic HEV in Severe Combined Immunodeficiency",

abstract = "Severe combined immunodeficiency (SCID) is a group of genetic disorders characterized by significant impairment of T cell differentiation, with or without abnormal B and NK cell differentiation. Without hematopoietic stem cell transplant (HSCT), the condition usually leads to an early death, typically due to infections. The most frequent genetic cause of SCID affects the common gamma chain, necessary for cytokine signaling. A similar phenotype is observed with mutations in the Janus-associated kinase 3 (JAK3) gene, the immediate downstream signaling molecule",

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Recurrent Chronic HEV in Severe Combined Immunodeficiency

Abstract

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