Recurrent Chronic HEV in Severe Combined Immunodeficiency

Severe combined immunodeficiency (SCID) is a group of genetic disorders characterized by significant impairment of T cell differentiation, with or without abnormal B and NK cell differentiation. Without hematopoietic stem cell transplant (HSCT), the condition usually leads to an early death, typically due to infections. The most frequent genetic cause of SCID affects the common gamma chain, necessary for cytokine signaling. A similar phenotype is observed with mutations in the Janus-associated kinase 3 (JAK3) gene, the immediate downstream signaling molecule