Reactivation of latent hepatitis B virus infection with HIV-related immunosuppression.

S. J. Clark; S. Creighton; M. Horner; H. M. Smith; B. Portmann; C. Taylor; M. E. Cramp

doi:10.1258/095646206775220612

Reactivation of latent hepatitis B virus infection with HIV-related immunosuppression.

S. J. Clark^*
, S. Creighton
, M. Horner
, H. M. Smith
, B. Portmann
, C. Taylor
, M. E. Cramp

^*Corresponding author for this work

Peninsula Medical School

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of HIV-related immunosuppression and antiretroviral therapy on the reactivation of latent hepatitis B virus (HBV) infection is unclear. We report four patients with advanced HIV-related immunosuppression and abnormal liver function tests who had evidence of HBV reactivation. Reclearance of hepatitis B occurred in two cases with HIV treatment regimens not containing lamivudine, suggesting that improved immune function may be responsible. In three cases, HBV reactivation was recognized during investigation for abnormal liver function initially attributed to drug toxicity. The possibility of HBV reactivation must be considered in the differential diagnosis of abnormal liver function in cases with advanced HIV.

Original language	English
Pages (from-to)	67-69
Number of pages	0
Journal	Int J STD AIDS
Volume	17
Issue number	1
DOIs	https://doi.org/10.1258/095646206775220612
Publication status	Published - Jan 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antiretroviral Therapy
Highly Active
HIV Infections
Hepatitis B
Hepatitis B virus
Humans
Immunosuppression Therapy
Male
Virus Activation
Virus Latency

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10.1258/095646206775220612

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title = "Reactivation of latent hepatitis B virus infection with HIV-related immunosuppression.",

abstract = "The effect of HIV-related immunosuppression and antiretroviral therapy on the reactivation of latent hepatitis B virus (HBV) infection is unclear. We report four patients with advanced HIV-related immunosuppression and abnormal liver function tests who had evidence of HBV reactivation. Reclearance of hepatitis B occurred in two cases with HIV treatment regimens not containing lamivudine, suggesting that improved immune function may be responsible. In three cases, HBV reactivation was recognized during investigation for abnormal liver function initially attributed to drug toxicity. The possibility of HBV reactivation must be considered in the differential diagnosis of abnormal liver function in cases with advanced HIV.",

keywords = "Antiretroviral Therapy, Highly Active, HIV Infections, Hepatitis B, Hepatitis B virus, Humans, Immunosuppression Therapy, Male, Virus Activation, Virus Latency",

author = "Clark, \{S. J.\} and S. Creighton and M. Horner and Smith, \{H. M.\} and B. Portmann and C. Taylor and Cramp, \{M. E.\}",

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T1 - Reactivation of latent hepatitis B virus infection with HIV-related immunosuppression.

AU - Clark, S. J.

AU - Creighton, S.

AU - Horner, M.

AU - Smith, H. M.

AU - Portmann, B.

AU - Taylor, C.

AU - Cramp, M. E.

PY - 2006/1

Y1 - 2006/1

N2 - The effect of HIV-related immunosuppression and antiretroviral therapy on the reactivation of latent hepatitis B virus (HBV) infection is unclear. We report four patients with advanced HIV-related immunosuppression and abnormal liver function tests who had evidence of HBV reactivation. Reclearance of hepatitis B occurred in two cases with HIV treatment regimens not containing lamivudine, suggesting that improved immune function may be responsible. In three cases, HBV reactivation was recognized during investigation for abnormal liver function initially attributed to drug toxicity. The possibility of HBV reactivation must be considered in the differential diagnosis of abnormal liver function in cases with advanced HIV.

AB - The effect of HIV-related immunosuppression and antiretroviral therapy on the reactivation of latent hepatitis B virus (HBV) infection is unclear. We report four patients with advanced HIV-related immunosuppression and abnormal liver function tests who had evidence of HBV reactivation. Reclearance of hepatitis B occurred in two cases with HIV treatment regimens not containing lamivudine, suggesting that improved immune function may be responsible. In three cases, HBV reactivation was recognized during investigation for abnormal liver function initially attributed to drug toxicity. The possibility of HBV reactivation must be considered in the differential diagnosis of abnormal liver function in cases with advanced HIV.

KW - Antiretroviral Therapy

KW - Highly Active

KW - HIV Infections

KW - Hepatitis B

KW - Hepatitis B virus

KW - Humans

KW - Immunosuppression Therapy

KW - Male

KW - Virus Activation

KW - Virus Latency

U2 - 10.1258/095646206775220612

DO - 10.1258/095646206775220612

M3 - Article

SN - 0956-4624

VL - 17

SP - 67

EP - 69

JO - Int J STD AIDS

JF - Int J STD AIDS

IS - 1

ER -

Reactivation of latent hepatitis B virus infection with HIV-related immunosuppression.

Abstract

UN SDGs

Keywords

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