Pseudo-CTs from T1-weighted MRI for planning of low-intensity transcranial focused ultrasound neuromodulation: An open-source tool

Siti N. Yaakub; Tristan A. White; Eric Kerfoot; Lennart Verhagen; Alexander Hammers; Elsa F. Fouragnan

doi:10.1016/j.brs.2023.01.838

Pseudo-CTs from T1-weighted MRI for planning of low-intensity transcranial focused ultrasound neuromodulation: An open-source tool

Siti N. Yaakub^*
, Tristan A. White
, Eric Kerfoot
, Lennart Verhagen
, Alexander Hammers
, Elsa F. Fouragnan

^*Corresponding author for this work

School of Psychology

King's College London
Radboud University Nijmegen

Research output: Contribution to journal › Letter › peer-review

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Abstract

We present a novel toolbox to generate computed tomography (CT) images from anatomical T1-weighted magnetic resonance (MR) images for use in planning transcranial ultrasound stimulation (TUS) studies in humans (https://github.com/sitiny/mr-topct). Our validated open-source toolbox is aimed at researchers interested in generating bespoke skull models for use in acoustic simulations in TUS studies. Importantly, researchers planning TUS studies will most likely already have access to standard T1-weighted MR images for neuronavigation, making our toolbox compatible with many existing protocols for TUS studies

Original language	English
Pages (from-to)	75-78
Journal	Brain Stimulation
Volume	16
Issue number	1
Early online date	17 Jan 2023
DOIs	https://doi.org/10.1016/j.brs.2023.01.838
Publication status	Published - 17 Jan 2023

Keywords

Non-invasive brain stimulation
Acoustic simulation
Multi-element transducer
Deep learning
Image synthesis
U-Net

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10.1016/j.brs.2023.01.838Licence: CC BY

Yaakub et alFinal published version, 920 KBLicence: CC BY

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title = "Pseudo-CTs from T1-weighted MRI for planning of low-intensity transcranial focused ultrasound neuromodulation: An open-source tool",

abstract = "We present a novel toolbox to generate computed tomography (CT) images from anatomical T1-weighted magnetic resonance (MR) images for use in planning transcranial ultrasound stimulation (TUS) studies in humans (https://github.com/sitiny/mr-topct). Our validated open-source toolbox is aimed at researchers interested in generating bespoke skull models for use in acoustic simulations in TUS studies. Importantly, researchers planning TUS studies will most likely already have access to standard T1-weighted MR images for neuronavigation, making our toolbox compatible with many existing protocols for TUS studies",

keywords = "Non-invasive brain stimulation, Acoustic simulation, Multi-element transducer, Deep learning, Image synthesis, U-Net",

author = "Yaakub, \{Siti N.\} and White, \{Tristan A.\} and Eric Kerfoot and Lennart Verhagen and Alexander Hammers and Fouragnan, \{Elsa F.\}",

year = "2023",

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doi = "10.1016/j.brs.2023.01.838",

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T1 - Pseudo-CTs from T1-weighted MRI for planning of low-intensity transcranial focused ultrasound neuromodulation: An open-source tool

AU - Yaakub, Siti N.

AU - White, Tristan A.

AU - Kerfoot, Eric

AU - Verhagen, Lennart

AU - Hammers, Alexander

AU - Fouragnan, Elsa F.

PY - 2023/1/17

Y1 - 2023/1/17

N2 - We present a novel toolbox to generate computed tomography (CT) images from anatomical T1-weighted magnetic resonance (MR) images for use in planning transcranial ultrasound stimulation (TUS) studies in humans (https://github.com/sitiny/mr-topct). Our validated open-source toolbox is aimed at researchers interested in generating bespoke skull models for use in acoustic simulations in TUS studies. Importantly, researchers planning TUS studies will most likely already have access to standard T1-weighted MR images for neuronavigation, making our toolbox compatible with many existing protocols for TUS studies

AB - We present a novel toolbox to generate computed tomography (CT) images from anatomical T1-weighted magnetic resonance (MR) images for use in planning transcranial ultrasound stimulation (TUS) studies in humans (https://github.com/sitiny/mr-topct). Our validated open-source toolbox is aimed at researchers interested in generating bespoke skull models for use in acoustic simulations in TUS studies. Importantly, researchers planning TUS studies will most likely already have access to standard T1-weighted MR images for neuronavigation, making our toolbox compatible with many existing protocols for TUS studies

KW - Non-invasive brain stimulation

KW - Acoustic simulation

KW - Multi-element transducer

KW - Deep learning

KW - Image synthesis

KW - U-Net

UR - https://pearl.plymouth.ac.uk/psy-research/415/

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DO - 10.1016/j.brs.2023.01.838

M3 - Letter

SN - 1935-861X

VL - 16

SP - 75

EP - 78

JO - Brain Stimulation

JF - Brain Stimulation

IS - 1

ER -

Pseudo-CTs from T1-weighted MRI for planning of low-intensity transcranial focused ultrasound neuromodulation: An open-source tool

Abstract

Keywords

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Pseudo-CTs from T1-weighted MRI for planning of low-intensity transcranial focused ultrasound neuromodulation: an open-source tool

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