Pain Medication Adherence in Patients with Cancer: A Pragmatic Review

Lorenz Vanneste; Tessa Lefebvre; Laura Tack; Eygen K Van; Lieselot Cool; Patricia A. Schofield; Tom Boterberg; Rijdt T De; Anne Verhaeghe; Katy Verhelle; Philip R. Debruyne

doi:10.1093/pm/pnab010

Pain Medication Adherence in Patients with Cancer: A Pragmatic Review

Lorenz Vanneste, Tessa Lefebvre, Laura Tack, Eygen K Van, Lieselot Cool, Patricia A. Schofield, Tom Boterberg, Rijdt T De, Anne Verhaeghe, Katy Verhelle, Philip R. Debruyne^*

^*Corresponding author for this work

School of Nursing and Midwifery

Research output: Contribution to journal › Article › peer-review

Abstract

Abstract Objective Adherence to pain medication in patients with cancer is crucial for successful pain therapy. This review aimed to investigate the rate of adherence, which factors influence adherence, whether adherence differs in diverse patient populations, whether there are methods to improve adherence, and the relationship between adherence and pain relief. Methods This review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. MEDLINE/PubMed, Embase, Web of Science, Cochrane, and ClinicalTrials.gov were searched. All types of studies investigating adherence of patients with cancer, factors influencing adherence, and methods to improve adherence to pain medication were included. They were first screened on title and abstract and thereafter on full text. Selected articles were subjected to a quality assessment according to the PRISMA checklist. From included articles, study characteristics and outcomes were extracted. Results Of 795 articles, 18 were included. Different methods were used to measure adherence, which led to adherence rates ranging from 8.9% to 82.0%. White Americans and men were found to be more adherent than African Americans and women. Because of various barriers, adherence is often suboptimal. Fear of addiction, physiological and harmful effects, tolerance, and disease progression are common concerns. Interventions, such as pain education booklets, pain consults, and specialized nurses, may be beneficial to increase the adherence. Lower adherence rates were associated with lower pain relief. Conclusion Adherence of cancer patients to pain medication is suboptimal. Health care workers should focus on addressing barriers to increase adherence to obtain better pain relief.

Original language	English
Pages (from-to)	782-798
Number of pages	0
Journal	Pain Medicine
Volume	23
Issue number	4
Early online date	27 Jan 2021
DOIs	https://doi.org/10.1093/pm/pnab010
Publication status	Published - 8 Apr 2022

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10.1093/pm/pnab010

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title = "Pain Medication Adherence in Patients with Cancer: A Pragmatic Review",

abstract = "Abstract Objective Adherence to pain medication in patients with cancer is crucial for successful pain therapy. This review aimed to investigate the rate of adherence, which factors influence adherence, whether adherence differs in diverse patient populations, whether there are methods to improve adherence, and the relationship between adherence and pain relief. Methods This review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. MEDLINE/PubMed, Embase, Web of Science, Cochrane, and ClinicalTrials.gov were searched. All types of studies investigating adherence of patients with cancer, factors influencing adherence, and methods to improve adherence to pain medication were included. They were first screened on title and abstract and thereafter on full text. Selected articles were subjected to a quality assessment according to the PRISMA checklist. From included articles, study characteristics and outcomes were extracted. Results Of 795 articles, 18 were included. Different methods were used to measure adherence, which led to adherence rates ranging from 8.9% to 82.0%. White Americans and men were found to be more adherent than African Americans and women. Because of various barriers, adherence is often suboptimal. Fear of addiction, physiological and harmful effects, tolerance, and disease progression are common concerns. Interventions, such as pain education booklets, pain consults, and specialized nurses, may be beneficial to increase the adherence. Lower adherence rates were associated with lower pain relief. Conclusion Adherence of cancer patients to pain medication is suboptimal. Health care workers should focus on addressing barriers to increase adherence to obtain better pain relief. ",

author = "Lorenz Vanneste and Tessa Lefebvre and Laura Tack and Van, {Eygen K} and Lieselot Cool and Schofield, {Patricia A.} and Tom Boterberg and De, {Rijdt T} and Anne Verhaeghe and Katy Verhelle and Debruyne, {Philip R.}",

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doi = "10.1093/pm/pnab010",

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T1 - Pain Medication Adherence in Patients with Cancer: A Pragmatic Review

AU - Vanneste, Lorenz

AU - Lefebvre, Tessa

AU - Tack, Laura

AU - Van, Eygen K

AU - Cool, Lieselot

AU - Schofield, Patricia A.

AU - Boterberg, Tom

AU - De, Rijdt T

AU - Verhaeghe, Anne

AU - Verhelle, Katy

AU - Debruyne, Philip R.

PY - 2022/4/8

Y1 - 2022/4/8

N2 - Abstract Objective Adherence to pain medication in patients with cancer is crucial for successful pain therapy. This review aimed to investigate the rate of adherence, which factors influence adherence, whether adherence differs in diverse patient populations, whether there are methods to improve adherence, and the relationship between adherence and pain relief. Methods This review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. MEDLINE/PubMed, Embase, Web of Science, Cochrane, and ClinicalTrials.gov were searched. All types of studies investigating adherence of patients with cancer, factors influencing adherence, and methods to improve adherence to pain medication were included. They were first screened on title and abstract and thereafter on full text. Selected articles were subjected to a quality assessment according to the PRISMA checklist. From included articles, study characteristics and outcomes were extracted. Results Of 795 articles, 18 were included. Different methods were used to measure adherence, which led to adherence rates ranging from 8.9% to 82.0%. White Americans and men were found to be more adherent than African Americans and women. Because of various barriers, adherence is often suboptimal. Fear of addiction, physiological and harmful effects, tolerance, and disease progression are common concerns. Interventions, such as pain education booklets, pain consults, and specialized nurses, may be beneficial to increase the adherence. Lower adherence rates were associated with lower pain relief. Conclusion Adherence of cancer patients to pain medication is suboptimal. Health care workers should focus on addressing barriers to increase adherence to obtain better pain relief.

AB - Abstract Objective Adherence to pain medication in patients with cancer is crucial for successful pain therapy. This review aimed to investigate the rate of adherence, which factors influence adherence, whether adherence differs in diverse patient populations, whether there are methods to improve adherence, and the relationship between adherence and pain relief. Methods This review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. MEDLINE/PubMed, Embase, Web of Science, Cochrane, and ClinicalTrials.gov were searched. All types of studies investigating adherence of patients with cancer, factors influencing adherence, and methods to improve adherence to pain medication were included. They were first screened on title and abstract and thereafter on full text. Selected articles were subjected to a quality assessment according to the PRISMA checklist. From included articles, study characteristics and outcomes were extracted. Results Of 795 articles, 18 were included. Different methods were used to measure adherence, which led to adherence rates ranging from 8.9% to 82.0%. White Americans and men were found to be more adherent than African Americans and women. Because of various barriers, adherence is often suboptimal. Fear of addiction, physiological and harmful effects, tolerance, and disease progression are common concerns. Interventions, such as pain education booklets, pain consults, and specialized nurses, may be beneficial to increase the adherence. Lower adherence rates were associated with lower pain relief. Conclusion Adherence of cancer patients to pain medication is suboptimal. Health care workers should focus on addressing barriers to increase adherence to obtain better pain relief.

U2 - 10.1093/pm/pnab010

DO - 10.1093/pm/pnab010

M3 - Article

SN - 1526-2375

VL - 23

SP - 782

EP - 798

JO - Pain Medicine

JF - Pain Medicine

IS - 4

ER -

Pain Medication Adherence in Patients with Cancer: A Pragmatic Review

Abstract

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