Outbreak investigation of NDM-producing Burkholderia cepacia causing neonatal sepsis in Pakistan

A Batool; A Yakoob; Zahid Anwar; Lovleen Tina Joshi; Durreshahwar Lone; M Zikriya; Qasim Ahmed; Muhammad Usman Qamar

doi:10.2217/fmb-2023-0063

Outbreak investigation of NDM-producing Burkholderia cepacia causing neonatal sepsis in Pakistan

A Batool, A Yakoob, Zahid Anwar, Lovleen Tina Joshi, Durreshahwar Lone, M Zikriya, Qasim Ahmed, Muhammad Usman Qamar^*

^*Corresponding author for this work

Peninsula Dental School

Research output: Contribution to journal › Article › peer-review

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Abstract

Aim: To investigate the outbreak of Burkholderia cepacia complex (BCC), mortality, antimicrobial resistance and associated risk factors in the neonatal intensive care unit. Method: Eighteen blood culture samples from neonates and twenty swab samples from different neonatal intensive care unit surfaces were collected. The VITEK 2 was used to confirm the isolates and generate the antibiogram. PCR was used to identify blaNDM. Results: Eighteen samples tested positive for BCC, and 10/18 (55.5%) of the neonates died. 13/18 (72%) of the neonates had late-onset neonatal sepsis, and 10/18 (55%) had low birth weight. Resistance to minocycline and chloramphenicol was 100%, 72.2% to meropenem; 72.2% NDM gene was found in neonates and was 20% from the environment. Conclusion: Outbreak of NDM-producing BCC resulting in high neonatal mortality in NICU.

Original language	English
Number of pages	0
Journal	Future Microbiology
Volume	0
Issue number	0
Early online date	18 Oct 2023
DOIs	https://doi.org/10.2217/fmb-2023-0063
Publication status	Published - 18 Oct 2023

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title = "Outbreak investigation of NDM-producing Burkholderia cepacia causing neonatal sepsis in Pakistan",

abstract = "Aim: To investigate the outbreak of Burkholderia cepacia complex (BCC), mortality, antimicrobial resistance and associated risk factors in the neonatal intensive care unit. Method: Eighteen blood culture samples from neonates and twenty swab samples from different neonatal intensive care unit surfaces were collected. The VITEK 2 was used to confirm the isolates and generate the antibiogram. PCR was used to identify blaNDM. Results: Eighteen samples tested positive for BCC, and 10/18 (55.5\%) of the neonates died. 13/18 (72\%) of the neonates had late-onset neonatal sepsis, and 10/18 (55\%) had low birth weight. Resistance to minocycline and chloramphenicol was 100\%, 72.2\% to meropenem; 72.2\% NDM gene was found in neonates and was 20\% from the environment. Conclusion: Outbreak of NDM-producing BCC resulting in high neonatal mortality in NICU.",

author = "A Batool and A Yakoob and Zahid Anwar and Joshi, \{Lovleen Tina\} and Durreshahwar Lone and M Zikriya and Qasim Ahmed and Qamar, \{Muhammad Usman\}",

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doi = "10.2217/fmb-2023-0063",

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T1 - Outbreak investigation of NDM-producing Burkholderia cepacia causing neonatal sepsis in Pakistan

AU - Batool, A

AU - Yakoob, A

AU - Anwar, Zahid

AU - Joshi, Lovleen Tina

AU - Lone, Durreshahwar

AU - Zikriya, M

AU - Ahmed, Qasim

AU - Qamar, Muhammad Usman

PY - 2023/10/18

Y1 - 2023/10/18

N2 - Aim: To investigate the outbreak of Burkholderia cepacia complex (BCC), mortality, antimicrobial resistance and associated risk factors in the neonatal intensive care unit. Method: Eighteen blood culture samples from neonates and twenty swab samples from different neonatal intensive care unit surfaces were collected. The VITEK 2 was used to confirm the isolates and generate the antibiogram. PCR was used to identify blaNDM. Results: Eighteen samples tested positive for BCC, and 10/18 (55.5%) of the neonates died. 13/18 (72%) of the neonates had late-onset neonatal sepsis, and 10/18 (55%) had low birth weight. Resistance to minocycline and chloramphenicol was 100%, 72.2% to meropenem; 72.2% NDM gene was found in neonates and was 20% from the environment. Conclusion: Outbreak of NDM-producing BCC resulting in high neonatal mortality in NICU.

AB - Aim: To investigate the outbreak of Burkholderia cepacia complex (BCC), mortality, antimicrobial resistance and associated risk factors in the neonatal intensive care unit. Method: Eighteen blood culture samples from neonates and twenty swab samples from different neonatal intensive care unit surfaces were collected. The VITEK 2 was used to confirm the isolates and generate the antibiogram. PCR was used to identify blaNDM. Results: Eighteen samples tested positive for BCC, and 10/18 (55.5%) of the neonates died. 13/18 (72%) of the neonates had late-onset neonatal sepsis, and 10/18 (55%) had low birth weight. Resistance to minocycline and chloramphenicol was 100%, 72.2% to meropenem; 72.2% NDM gene was found in neonates and was 20% from the environment. Conclusion: Outbreak of NDM-producing BCC resulting in high neonatal mortality in NICU.

UR - https://pearl.plymouth.ac.uk/pds-research/304/

U2 - 10.2217/fmb-2023-0063

DO - 10.2217/fmb-2023-0063

M3 - Article

SN - 1746-0913

VL - 0

JO - Future Microbiology

JF - Future Microbiology

IS - 0

ER -

Outbreak investigation of NDM-producing Burkholderia cepacia causing neonatal sepsis in Pakistan

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