Oral health and pathology: a macrophage account.

Rebecca Merry; Louise Belfield; Paul McArdle; Andrew McLennan; Stjohn Crean; Andrew Foey

doi:10.1016/j.bjoms.2010.10.020

Oral health and pathology: a macrophage account.

Rebecca Merry
, Louise Belfield
, Paul McArdle
, Andrew McLennan
, Stjohn Crean
, Andrew Foey^*

^*Corresponding author for this work

School of Biomedical Sciences

University Hospitals Plymouth NHS Trust
Royal Devon & Exeter NHS Foundation Trust
University of Central Lancashire

Research output: Contribution to journal › Article › peer-review

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Abstract

Macrophages are present in healthy oral mucosa and their numbers increase dramatically during disease. They can exhibit a diverse range of phenotypes characterised as a functional spectrum from pro-inflammatory to anti-inflammatory (regulatory) subsets. This review illustrates the role of these subsets in the oral inflammatory disease lichen planus, and the immunosuppressive disease oral squamous cell carcinoma (SCC). We conclude that the role of macrophages in driving progression in oral disease identifies them as potential therapeutic targets for a range of oral pathologies.

Original language	English
Pages (from-to)	2-7
Number of pages	0
Journal	Br J Oral Maxillofac Surg
Volume	50
Issue number	1
DOIs	https://doi.org/10.1016/j.bjoms.2010.10.020
Publication status	Published - Jan 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Carcinoma
Squamous Cell
Cell Count
Cell Transformation
Neoplastic
Humans
Lichen Planus
Oral
Macrophages
Mouth Diseases
Mouth Mucosa
Mouth Neoplasms
Phenotype

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10.1016/j.bjoms.2010.10.020

19 Foey 2012 BJOMS Macrophage Review

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title = "Oral health and pathology: a macrophage account.",

abstract = "Macrophages are present in healthy oral mucosa and their numbers increase dramatically during disease. They can exhibit a diverse range of phenotypes characterised as a functional spectrum from pro-inflammatory to anti-inflammatory (regulatory) subsets. This review illustrates the role of these subsets in the oral inflammatory disease lichen planus, and the immunosuppressive disease oral squamous cell carcinoma (SCC). We conclude that the role of macrophages in driving progression in oral disease identifies them as potential therapeutic targets for a range of oral pathologies.",

keywords = "Carcinoma, Squamous Cell, Cell Count, Cell Transformation, Neoplastic, Humans, Lichen Planus, Oral, Macrophages, Mouth Diseases, Mouth Mucosa, Mouth Neoplasms, Phenotype",

author = "Rebecca Merry and Louise Belfield and Paul McArdle and Andrew McLennan and Stjohn Crean and Andrew Foey",

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language = "English",

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T1 - Oral health and pathology: a macrophage account.

AU - Merry, Rebecca

AU - Belfield, Louise

AU - McArdle, Paul

AU - McLennan, Andrew

AU - Crean, Stjohn

AU - Foey, Andrew

PY - 2012/1

Y1 - 2012/1

N2 - Macrophages are present in healthy oral mucosa and their numbers increase dramatically during disease. They can exhibit a diverse range of phenotypes characterised as a functional spectrum from pro-inflammatory to anti-inflammatory (regulatory) subsets. This review illustrates the role of these subsets in the oral inflammatory disease lichen planus, and the immunosuppressive disease oral squamous cell carcinoma (SCC). We conclude that the role of macrophages in driving progression in oral disease identifies them as potential therapeutic targets for a range of oral pathologies.

AB - Macrophages are present in healthy oral mucosa and their numbers increase dramatically during disease. They can exhibit a diverse range of phenotypes characterised as a functional spectrum from pro-inflammatory to anti-inflammatory (regulatory) subsets. This review illustrates the role of these subsets in the oral inflammatory disease lichen planus, and the immunosuppressive disease oral squamous cell carcinoma (SCC). We conclude that the role of macrophages in driving progression in oral disease identifies them as potential therapeutic targets for a range of oral pathologies.

KW - Carcinoma

KW - Squamous Cell

KW - Cell Count

KW - Cell Transformation

KW - Neoplastic

KW - Humans

KW - Lichen Planus

KW - Oral

KW - Macrophages

KW - Mouth Diseases

KW - Mouth Mucosa

KW - Mouth Neoplasms

KW - Phenotype

UR - https://pearl.plymouth.ac.uk/bhs-research/8/

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DO - 10.1016/j.bjoms.2010.10.020

M3 - Article

SN - 1532-1940

VL - 50

SP - 2

EP - 7

JO - Br J Oral Maxillofac Surg

JF - Br J Oral Maxillofac Surg

IS - 1

ER -

Oral health and pathology: a macrophage account.

Abstract

UN SDGs

Keywords

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