Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

Zobair M. Younossi; Vlad Ratziu; Rohit Loomba; Mary Rinella; Quentin M. Anstee; Zachary Goodman; Pierre Bedossa; Andreas Geier; Susanne Beckebaum; Philip N. Newsome; David Sheridan; Muhammad Y. Sheikh; James Trotter; Whitfield Knapple; Eric Lawitz; Manal F. Abdelmalek; Kris V. Kowdley; Aldo J. Montano-Loza; Jerome Boursier; Philippe Mathurin; Elisabetta Bugianesi; Giuseppe Mazzella; Antonio Olveira; Helena Cortez-Pinto; Isabel Graupera; David Orr; Lise Lotte Gluud; Jean Francois Dufour; David Shapiro; Jason Campagna; Luna Zaru; Leigh MacConell; Reshma Shringarpure; Stephen Harrison; Arun J. Sanyal; Manal F. Abdelmalek; Gary Abrams; Humberto Aguilar; Aijaz Ahmed; Elmar Aigner; Guruprasad Aithal; Aftab Ala; William Alazawi; Agustin Albillos; Michael Allison; Sfa Al-Shamma; Raul Andrade; Pietro Andreone; Mario Angelico; Victor Ankoma-Sey; Quentin M. Anstee; Rodolphe Anty; V Araya; Ruiz JI Arenas; P Arkkila; M Arora; T Asselah; J Au; O Ayonrinde; RJ Bailey; M Balakrishnan; K Bambha; M Bansal; S Barritt; J Bate; J Beato; Susanne Beckebaum; J Behari; P Bellot; Ari Z Ben; M Bennett; M Berenguer; BT Beretta-Piccoli; T Berg; M Bonacini; L Bonet; B Borg; M Bourliere; Jerome Boursier; W Bowman; D Bradley; M Brankovic; M Braun; J-P Bronowicki; S Bruno; Elisabetta Bugianesi; C Cai; Panero JL Calleja

doi:10.1016/s0140-6736(19)33041-7

Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

Zobair M. Younossi
, Vlad Ratziu
, Rohit Loomba
, Mary Rinella
, Quentin M. Anstee
, Zachary Goodman
, Pierre Bedossa
, Andreas Geier
, Susanne Beckebaum
, Philip N. Newsome
, David Sheridan
, Muhammad Y. Sheikh
, James Trotter
, Whitfield Knapple
, Eric Lawitz
, Manal F. Abdelmalek
, Kris V. Kowdley
, Aldo J. Montano-Loza
, Jerome Boursier
, Philippe Mathurin

Elisabetta Bugianesi, Giuseppe Mazzella, Antonio Olveira, Helena Cortez-Pinto, Isabel Graupera, David Orr, Lise Lotte Gluud, Jean Francois Dufour, David Shapiro, Jason Campagna, Luna Zaru, Leigh MacConell, Reshma Shringarpure, Stephen Harrison, Arun J. Sanyal^*, Manal F. Abdelmalek, Gary Abrams, Humberto Aguilar, Aijaz Ahmed, Elmar Aigner, Guruprasad Aithal, Aftab Ala, William Alazawi, Agustin Albillos, Michael Allison, Sfa Al-Shamma, Raul Andrade, Pietro Andreone, Mario Angelico, Victor Ankoma-Sey, Quentin M. Anstee, Rodolphe Anty, V Araya, Ruiz JI Arenas, P Arkkila, M Arora, T Asselah, J Au, O Ayonrinde, RJ Bailey, M Balakrishnan, K Bambha, M Bansal, S Barritt, J Bate, J Beato, Susanne Beckebaum, J Behari, P Bellot, Ari Z Ben, M Bennett, M Berenguer, BT Beretta-Piccoli, T Berg, M Bonacini, L Bonet, B Borg, M Bourliere, Jerome Boursier, W Bowman, D Bradley, M Brankovic, M Braun, J-P Bronowicki, S Bruno, Elisabetta Bugianesi, C Cai, Panero JL Calleja

^*Corresponding author for this work

Peninsula Medical School

Research output: Contribution to journal › Article › peer-review

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Original language	English
Number of pages	0
Journal	The Lancet
Volume	0
Issue number	0
Early online date	5 Dec 2019
DOIs	https://doi.org/10.1016/s0140-6736(19)33041-7
Publication status	Published - Dec 2019

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10.1016/s0140-6736(19)33041-7

Younossi (Lancet 2019 Resub Appendix) REGENERATE IA (24Oct2019)FInal SubmittedOther version, 648 KB
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Younossi, Z. M., Ratziu, V., Loomba, R., Rinella, M., Anstee, Q. M., Goodman, Z., Bedossa, P., Geier, A., Beckebaum, S., Newsome, P. N., Sheridan, D., Sheikh, M. Y., Trotter, J., Knapple, W., Lawitz, E., Abdelmalek, M. F., Kowdley, K. V., Montano-Loza, A. J., Boursier, J., ... Calleja, P. JL. (2019). Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial. The Lancet, 0(0). https://doi.org/10.1016/s0140-6736(19)33041-7

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title = "Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial",

author = "Younossi, \{Zobair M.\} and Vlad Ratziu and Rohit Loomba and Mary Rinella and Anstee, \{Quentin M.\} and Zachary Goodman and Pierre Bedossa and Andreas Geier and Susanne Beckebaum and Newsome, \{Philip N.\} and David Sheridan and Sheikh, \{Muhammad Y.\} and James Trotter and Whitfield Knapple and Eric Lawitz and Abdelmalek, \{Manal F.\} and Kowdley, \{Kris V.\} and Montano-Loza, \{Aldo J.\} and Jerome Boursier and Philippe Mathurin and Elisabetta Bugianesi and Giuseppe Mazzella and Antonio Olveira and Helena Cortez-Pinto and Isabel Graupera and David Orr and Gluud, \{Lise Lotte\} and Dufour, \{Jean Francois\} and David Shapiro and Jason Campagna and Luna Zaru and Leigh MacConell and Reshma Shringarpure and Stephen Harrison and Sanyal, \{Arun J.\} and Abdelmalek, \{Manal F.\} and Gary Abrams and Humberto Aguilar and Aijaz Ahmed and Elmar Aigner and Guruprasad Aithal and Aftab Ala and William Alazawi and Agustin Albillos and Michael Allison and Sfa Al-Shamma and Raul Andrade and Pietro Andreone and Mario Angelico and Victor Ankoma-Sey and Anstee, \{Quentin M.\} and Rodolphe Anty and V Araya and Arenas, \{Ruiz JI\} and P Arkkila and M Arora and T Asselah and J Au and O Ayonrinde and RJ Bailey and M Balakrishnan and K Bambha and M Bansal and S Barritt and J Bate and J Beato and Susanne Beckebaum and J Behari and P Bellot and Ben, \{Ari Z\} and M Bennett and M Berenguer and BT Beretta-Piccoli and T Berg and M Bonacini and L Bonet and B Borg and M Bourliere and Jerome Boursier and W Bowman and D Bradley and M Brankovic and M Braun and J-P Bronowicki and S Bruno and Elisabetta Bugianesi and C Cai and Calleja, \{Panero JL\}",

year = "2019",

month = dec,

doi = "10.1016/s0140-6736(19)33041-7",

language = "English",

volume = "0",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier B.V.",

number = "0",

}

Younossi, ZM, Ratziu, V, Loomba, R, Rinella, M, Anstee, QM, Goodman, Z, Bedossa, P, Geier, A, Beckebaum, S, Newsome, PN, Sheridan, D, Sheikh, MY, Trotter, J, Knapple, W, Lawitz, E, Abdelmalek, MF, Kowdley, KV, Montano-Loza, AJ, Boursier, J, Mathurin, P, Bugianesi, E, Mazzella, G, Olveira, A, Cortez-Pinto, H, Graupera, I, Orr, D, Gluud, LL, Dufour, JF, Shapiro, D, Campagna, J, Zaru, L, MacConell, L, Shringarpure, R, Harrison, S, Sanyal, AJ, Abdelmalek, MF, Abrams, G, Aguilar, H, Ahmed, A, Aigner, E, Aithal, G, Ala, A, Alazawi, W, Albillos, A, Allison, M, Al-Shamma, S, Andrade, R, Andreone, P, Angelico, M, Ankoma-Sey, V, Anstee, QM, Anty, R, Araya, V, Arenas, RJI, Arkkila, P, Arora, M, Asselah, T, Au, J, Ayonrinde, O, Bailey, RJ, Balakrishnan, M, Bambha, K, Bansal, M, Barritt, S, Bate, J, Beato, J, Beckebaum, S, Behari, J, Bellot, P, Ben, AZ, Bennett, M, Berenguer, M, Beretta-Piccoli, BT, Berg, T, Bonacini, M, Bonet, L, Borg, B, Bourliere, M, Boursier, J, Bowman, W, Bradley, D, Brankovic, M, Braun, M, Bronowicki, J-P, Bruno, S, Bugianesi, E, Cai, C & Calleja, PJL 2019, 'Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial', The Lancet, vol. 0, no. 0. https://doi.org/10.1016/s0140-6736(19)33041-7

TY - JOUR

T1 - Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

AU - Younossi, Zobair M.

AU - Ratziu, Vlad

AU - Loomba, Rohit

AU - Rinella, Mary

AU - Anstee, Quentin M.

AU - Goodman, Zachary

AU - Bedossa, Pierre

AU - Geier, Andreas

AU - Beckebaum, Susanne

AU - Newsome, Philip N.

AU - Sheridan, David

AU - Sheikh, Muhammad Y.

AU - Trotter, James

AU - Knapple, Whitfield

AU - Lawitz, Eric

AU - Abdelmalek, Manal F.

AU - Kowdley, Kris V.

AU - Montano-Loza, Aldo J.

AU - Boursier, Jerome

AU - Mathurin, Philippe

AU - Bugianesi, Elisabetta

AU - Mazzella, Giuseppe

AU - Olveira, Antonio

AU - Cortez-Pinto, Helena

AU - Graupera, Isabel

AU - Orr, David

AU - Gluud, Lise Lotte

AU - Dufour, Jean Francois

AU - Shapiro, David

AU - Campagna, Jason

AU - Zaru, Luna

AU - MacConell, Leigh

AU - Shringarpure, Reshma

AU - Harrison, Stephen

AU - Sanyal, Arun J.

AU - Abdelmalek, Manal F.

AU - Abrams, Gary

AU - Aguilar, Humberto

AU - Ahmed, Aijaz

AU - Aigner, Elmar

AU - Aithal, Guruprasad

AU - Ala, Aftab

AU - Alazawi, William

AU - Albillos, Agustin

AU - Allison, Michael

AU - Al-Shamma, Sfa

AU - Andrade, Raul

AU - Andreone, Pietro

AU - Angelico, Mario

AU - Ankoma-Sey, Victor

AU - Anstee, Quentin M.

AU - Anty, Rodolphe

AU - Araya, V

AU - Arenas, Ruiz JI

AU - Arkkila, P

AU - Arora, M

AU - Asselah, T

AU - Au, J

AU - Ayonrinde, O

AU - Bailey, RJ

AU - Balakrishnan, M

AU - Bambha, K

AU - Bansal, M

AU - Barritt, S

AU - Bate, J

AU - Beato, J

AU - Beckebaum, Susanne

AU - Behari, J

AU - Bellot, P

AU - Ben, Ari Z

AU - Bennett, M

AU - Berenguer, M

AU - Beretta-Piccoli, BT

AU - Berg, T

AU - Bonacini, M

AU - Bonet, L

AU - Borg, B

AU - Bourliere, M

AU - Boursier, Jerome

AU - Bowman, W

AU - Bradley, D

AU - Brankovic, M

AU - Braun, M

AU - Bronowicki, J-P

AU - Bruno, S

AU - Bugianesi, Elisabetta

AU - Cai, C

AU - Calleja, Panero JL

PY - 2019/12

Y1 - 2019/12

UR - https://pearl.plymouth.ac.uk/pms-research/177/

U2 - 10.1016/s0140-6736(19)33041-7

DO - 10.1016/s0140-6736(19)33041-7

M3 - Article

SN - 0140-6736

VL - 0

JO - The Lancet

JF - The Lancet

IS - 0

ER -

Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

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