Nitrous oxide in modern anaesthetic practice

S. M. Brown; J. R. Sneyd

doi:10.1093/bjaceaccp/mkv019

Nitrous oxide in modern anaesthetic practice

S. M. Brown, J. R. Sneyd^*

^*Corresponding author for this work

University Hospitals Plymouth NHS Trust

Research output: Contribution to journal › Article › peer-review

Abstract

Nitrous oxide is an N-methyl--aspartate receptor antagonist and may reduce the incidence of chronic post-surgical pain. • Nitrous oxide oxidizes Vitamin B12 and can precipitate sub-acute combined degeneration of the cord with chronic use or in patients with folate/B12 deficiency. • Nitrous oxide expands air spaces and is contraindicated in patients with pneumothorax or recent (up to 4–6 weeks) ocular surgery using intraocular gas. • Nitrous oxide has global warming and ozone depletion potential and its concentration in the theatre environment is regulated. • The ENIGMA-II trial showed that nitrous oxide does not increase the risk of death or cardiovascular complications.

Original language	English
Pages (from-to)	87-91
Number of pages	5
Journal	BJA Education
Volume	16
Issue number	3
DOIs	https://doi.org/10.1093/bjaceaccp/mkv019
Publication status	Published - 1 Mar 2016

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

Keywords

1A01
1A02

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10.1093/bjaceaccp/mkv019

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AB - Nitrous oxide is an N-methyl--aspartate receptor antagonist and may reduce the incidence of chronic post-surgical pain. • Nitrous oxide oxidizes Vitamin B12 and can precipitate sub-acute combined degeneration of the cord with chronic use or in patients with folate/B12 deficiency. • Nitrous oxide expands air spaces and is contraindicated in patients with pneumothorax or recent (up to 4–6 weeks) ocular surgery using intraocular gas. • Nitrous oxide has global warming and ozone depletion potential and its concentration in the theatre environment is regulated. • The ENIGMA-II trial showed that nitrous oxide does not increase the risk of death or cardiovascular complications.

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Nitrous oxide in modern anaesthetic practice

Abstract

ASJC Scopus subject areas

Keywords

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