Abstract
Recently, nicotinic acid adenine dinucleotide phosphate (NAADP) has been shown, using different techniques, to mobilize intracellular Ca2+ stores in invertebrate, lower vertebrate, plant and mammalian cells. This endogenous molecule might play an atypical role in Ca2+ signalling by coordinating the responses of other Ca2+-releasing messengers. Furthermore, radioligand binding experiments have provided an insight into how desensitization of the NAADP receptor might occur.
| Original language | English |
|---|---|
| Pages (from-to) | 165-167 |
| Number of pages | 0 |
| Journal | Trends Pharmacol Sci |
| Volume | 23 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2002 |
Keywords
- Animals
- Calcium
- Calcium Signaling
- Humans
- NADP
- Ryanodine Receptor Calcium Release Channel
- Second Messenger Systems