Multiple Organ Dysfunction Syndrome

Nicholas M. Gourd, Nikitas Nikitas*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Multiple organ dysfunction syndrome (MODS) is one of the most common syndromes of critical illness and the leading cause of mortality among critically ill patients. Multiple organ dysfunction syndrome is the clinical consequence of a dysregulated inflammatory response, triggered by clinically diverse factors with the main pillar of management being invasive organ support. During the last years, the advances in the clarification of the molecular pathways that trigger, mitigate, and determine the outcome of MODS have led to the increasing recognition of MODS as a distinct disease entity with distinct etiology, pathophysiology, and potential future therapeutic interventions. Given the lack of effective treatment for MODS, its early recognition, the early intensive care unit admission, and the initiation of invasive organ support remain the most effective strategies of preventing its progression and improving outcomes.

Original languageEnglish
Pages (from-to)1564-1575
Number of pages12
JournalJournal of Intensive Care Medicine
Volume35
Issue number12
DOIs
Publication statusPublished - Dec 2020
Externally publishedYes

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Keywords

  • inflammation
  • multiple organ dysfunction
  • pathophysiology

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