Modelling the effect of venous disease on quality of life

D. Carradice; F. A.K. Mazari; N. Samuel; V. Allgar; J. Hatfield; I. C. Chetter

doi:10.1002/bjs.7500

Modelling the effect of venous disease on quality of life

D. Carradice^*, F. A.K. Mazari, N. Samuel, V. Allgar, J. Hatfield, I. C. Chetter

^*Corresponding author for this work

Peninsula Medical School

Hull York Medical School

Research output: Contribution to journal › Article › peer-review

Abstract

Abstract Background A clear understanding of the relationship between venous reflux, clinical venous disease and the effects on quality of life (QoL) remains elusive. This study aimed to explore the impact of venous disease, and assess any incremental direct effect of progressive disease on health-related QoL, with the ultimate aim to model venous morbidity. Methods Consecutive patients with venous disease were assessed for inclusion in the study. Patients with isolated, unilateral, single superficial axial incompetence diagnosed on duplex imaging were included. Clinical grading was performed with the Clinical Etiologic Anatomic Pathophysiologic (CEAP) classification and Venous Clinical Severity Score (VCSS). Patients completed generic (Short Form 36, SF-36®; EuroQol 5D, EQ-5D™) and disease-specific (Aberdeen Varicose Vein Questionnaire, AVVQ) QoL instruments. Multivariable regression modelling was performed, taking account of demographic and anatomical factors, to explore the effect of clinical severity on QoL impairment. Results Some 456 patients with C2–6 venous disease were included, along with control data for 105 people with C0–1 disease. Increasing clinical grade corresponded strongly with deterioration in disease-specific QoL (P &lt; 0·001). This could be stratified into three distinguishable groups: C0–1, C2–4 and C5–6 (P &lt; 0·001 to P = 0·006). Increasing clinical grade also corresponded with deterioration in the physical domains of SF-36® (P &lt; 0·001 to P = 0·016), along with EQ-5D™ index utility (quality-adjusted life year) scores (P &lt; 0·001). Conclusion Demonstrable morbidity was seen, even with uncomplicated venous disease. The physical impairment seen with venous ulceration was comparable with that seen in congestive cardiac failure and chronic lung disease.

Original language	English
Pages (from-to)	1089-1098
Number of pages	0
Journal	British Journal of Surgery
Volume	98
Issue number	8
Early online date	20 May 2011
DOIs	https://doi.org/10.1002/bjs.7500
Publication status	Published - 1 Jul 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/bjs.7500

Cite this

@article{4c0b9c4cb8b34eb9acf4da3e5b86002d,

title = "Modelling the effect of venous disease on quality of life",

abstract = "Abstract Background A clear understanding of the relationship between venous reflux, clinical venous disease and the effects on quality of life (QoL) remains elusive. This study aimed to explore the impact of venous disease, and assess any incremental direct effect of progressive disease on health-related QoL, with the ultimate aim to model venous morbidity. Methods Consecutive patients with venous disease were assessed for inclusion in the study. Patients with isolated, unilateral, single superficial axial incompetence diagnosed on duplex imaging were included. Clinical grading was performed with the Clinical Etiologic Anatomic Pathophysiologic (CEAP) classification and Venous Clinical Severity Score (VCSS). Patients completed generic (Short Form 36, SF-36{\textregistered}; EuroQol 5D, EQ-5D{\texttrademark}) and disease-specific (Aberdeen Varicose Vein Questionnaire, AVVQ) QoL instruments. Multivariable regression modelling was performed, taking account of demographic and anatomical factors, to explore the effect of clinical severity on QoL impairment. Results Some 456 patients with C2–6 venous disease were included, along with control data for 105 people with C0–1 disease. Increasing clinical grade corresponded strongly with deterioration in disease-specific QoL (P < 0·001). This could be stratified into three distinguishable groups: C0–1, C2–4 and C5–6 (P < 0·001 to P = 0·006). Increasing clinical grade also corresponded with deterioration in the physical domains of SF-36{\textregistered} (P < 0·001 to P = 0·016), along with EQ-5D{\texttrademark} index utility (quality-adjusted life year) scores (P < 0·001). Conclusion Demonstrable morbidity was seen, even with uncomplicated venous disease. The physical impairment seen with venous ulceration was comparable with that seen in congestive cardiac failure and chronic lung disease. ",

author = "D. Carradice and Mazari, {F. A.K.} and N. Samuel and V. Allgar and J. Hatfield and Chetter, {I. C.}",

year = "2011",

month = jul,

day = "1",

doi = "10.1002/bjs.7500",

language = "English",

volume = "98",

pages = "1089--1098",

journal = "British Journal of Surgery",

issn = "0007-1323",

publisher = "Oxford University Press",

number = "8",

}

TY - JOUR

T1 - Modelling the effect of venous disease on quality of life

AU - Carradice, D.

AU - Mazari, F. A.K.

AU - Samuel, N.

AU - Allgar, V.

AU - Hatfield, J.

AU - Chetter, I. C.

PY - 2011/7/1

Y1 - 2011/7/1

N2 - Abstract Background A clear understanding of the relationship between venous reflux, clinical venous disease and the effects on quality of life (QoL) remains elusive. This study aimed to explore the impact of venous disease, and assess any incremental direct effect of progressive disease on health-related QoL, with the ultimate aim to model venous morbidity. Methods Consecutive patients with venous disease were assessed for inclusion in the study. Patients with isolated, unilateral, single superficial axial incompetence diagnosed on duplex imaging were included. Clinical grading was performed with the Clinical Etiologic Anatomic Pathophysiologic (CEAP) classification and Venous Clinical Severity Score (VCSS). Patients completed generic (Short Form 36, SF-36®; EuroQol 5D, EQ-5D™) and disease-specific (Aberdeen Varicose Vein Questionnaire, AVVQ) QoL instruments. Multivariable regression modelling was performed, taking account of demographic and anatomical factors, to explore the effect of clinical severity on QoL impairment. Results Some 456 patients with C2–6 venous disease were included, along with control data for 105 people with C0–1 disease. Increasing clinical grade corresponded strongly with deterioration in disease-specific QoL (P < 0·001). This could be stratified into three distinguishable groups: C0–1, C2–4 and C5–6 (P < 0·001 to P = 0·006). Increasing clinical grade also corresponded with deterioration in the physical domains of SF-36® (P < 0·001 to P = 0·016), along with EQ-5D™ index utility (quality-adjusted life year) scores (P < 0·001). Conclusion Demonstrable morbidity was seen, even with uncomplicated venous disease. The physical impairment seen with venous ulceration was comparable with that seen in congestive cardiac failure and chronic lung disease.

AB - Abstract Background A clear understanding of the relationship between venous reflux, clinical venous disease and the effects on quality of life (QoL) remains elusive. This study aimed to explore the impact of venous disease, and assess any incremental direct effect of progressive disease on health-related QoL, with the ultimate aim to model venous morbidity. Methods Consecutive patients with venous disease were assessed for inclusion in the study. Patients with isolated, unilateral, single superficial axial incompetence diagnosed on duplex imaging were included. Clinical grading was performed with the Clinical Etiologic Anatomic Pathophysiologic (CEAP) classification and Venous Clinical Severity Score (VCSS). Patients completed generic (Short Form 36, SF-36®; EuroQol 5D, EQ-5D™) and disease-specific (Aberdeen Varicose Vein Questionnaire, AVVQ) QoL instruments. Multivariable regression modelling was performed, taking account of demographic and anatomical factors, to explore the effect of clinical severity on QoL impairment. Results Some 456 patients with C2–6 venous disease were included, along with control data for 105 people with C0–1 disease. Increasing clinical grade corresponded strongly with deterioration in disease-specific QoL (P < 0·001). This could be stratified into three distinguishable groups: C0–1, C2–4 and C5–6 (P < 0·001 to P = 0·006). Increasing clinical grade also corresponded with deterioration in the physical domains of SF-36® (P < 0·001 to P = 0·016), along with EQ-5D™ index utility (quality-adjusted life year) scores (P < 0·001). Conclusion Demonstrable morbidity was seen, even with uncomplicated venous disease. The physical impairment seen with venous ulceration was comparable with that seen in congestive cardiac failure and chronic lung disease.

U2 - 10.1002/bjs.7500

DO - 10.1002/bjs.7500

M3 - Article

SN - 0007-1323

VL - 98

SP - 1089

EP - 1098

JO - British Journal of Surgery

JF - British Journal of Surgery

IS - 8

ER -

Modelling the effect of venous disease on quality of life

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this