Mitogen-Activated Protein Kinase Cross-Talk Interaction Modulates the Production of Melanins in Aspergillus fumigatus

AO Manfiolli; FS Siqueira; Reis TF dos; Dijck P Van; S Schrevens; S Hoefgen; M Föge; M Straßburger; Leandro Jose De Assis; T Heinekamp; MC Rocha; S Janevska; AA Brakhage; I Malavazi; GH Goldman; V Valiante

doi:10.1128/mbio.00215-19

Mitogen-Activated Protein Kinase Cross-Talk Interaction Modulates the Production of Melanins in Aspergillus fumigatus

AO Manfiolli, FS Siqueira, Reis TF dos, Dijck P Van, S Schrevens, S Hoefgen, M Föge, M Straßburger, Leandro Jose De Assis, T Heinekamp, MC Rocha, S Janevska, AA Brakhage, I Malavazi, GH Goldman, V Valiante

Peninsula Medical School

Research output: Contribution to journal › Article › peer-review

Abstract

Aspergillus fumigatus is the most important airborne human pathogenic fungus, causing thousands of deaths per year. Its lethality is due to late and often inaccurate diagnosis and the lack of efficient therapeutics. The failure of efficient prophylaxis and therapy is based on the ability of this pathogen to activate numerous salvage pathways that are capable of overcoming the different drug-derived stresses. A major role in the protection of A. fumigatus is played by melanins. Melanins are cell wall-associated macromolecules classified as virulence determinants. The understanding of the various signaling pathways acting in this organism can be used to elucidate the mechanism beyond melanin production and help to identify ideal drug targets.

Original language	English
Journal	mBio
Volume	10
Issue number	2
DOIs	https://doi.org/10.1128/mbio.00215-19
Publication status	Published - 30 Apr 2019

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10.1128/mbio.00215-19

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Mitogen-Activated Protein Kinase Cross-Talk Interaction Modulates the Production of Melanins in Aspergillus fumigatus
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Manfiolli, AO., Siqueira, FS., dos, R. TF., Van, D. P., Schrevens, S., Hoefgen, S., Föge, M., Straßburger, M., De Assis, L. J., Heinekamp, T., Rocha, MC., Janevska, S., Brakhage, AA., Malavazi, I., Goldman, GH., & Valiante, V. (2019). Mitogen-Activated Protein Kinase Cross-Talk Interaction Modulates the Production of Melanins in Aspergillus fumigatus. mBio, 10(2). https://doi.org/10.1128/mbio.00215-19

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title = "Mitogen-Activated Protein Kinase Cross-Talk Interaction Modulates the Production of Melanins in Aspergillus fumigatus",

abstract = " Aspergillus fumigatus is the most important airborne human pathogenic fungus, causing thousands of deaths per year. Its lethality is due to late and often inaccurate diagnosis and the lack of efficient therapeutics. The failure of efficient prophylaxis and therapy is based on the ability of this pathogen to activate numerous salvage pathways that are capable of overcoming the different drug-derived stresses. A major role in the protection of A. fumigatus is played by melanins. Melanins are cell wall-associated macromolecules classified as virulence determinants. The understanding of the various signaling pathways acting in this organism can be used to elucidate the mechanism beyond melanin production and help to identify ideal drug targets. ",

author = "AO Manfiolli and FS Siqueira and dos, {Reis TF} and Van, {Dijck P} and S Schrevens and S Hoefgen and M F{\"o}ge and M Stra{\ss}burger and {De Assis}, {Leandro Jose} and T Heinekamp and MC Rocha and S Janevska and AA Brakhage and I Malavazi and GH Goldman and V Valiante",

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doi = "10.1128/mbio.00215-19",

language = "English",

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Manfiolli, AO, Siqueira, FS, dos, RTF, Van, DP, Schrevens, S, Hoefgen, S, Föge, M, Straßburger, M, De Assis, LJ, Heinekamp, T, Rocha, MC, Janevska, S, Brakhage, AA, Malavazi, I, Goldman, GH & Valiante, V 2019, 'Mitogen-Activated Protein Kinase Cross-Talk Interaction Modulates the Production of Melanins in Aspergillus fumigatus', mBio, vol. 10, no. 2. https://doi.org/10.1128/mbio.00215-19

TY - JOUR

T1 - Mitogen-Activated Protein Kinase Cross-Talk Interaction Modulates the Production of Melanins in Aspergillus fumigatus

AU - Manfiolli, AO

AU - Siqueira, FS

AU - dos, Reis TF

AU - Van, Dijck P

AU - Schrevens, S

AU - Hoefgen, S

AU - Föge, M

AU - Straßburger, M

AU - De Assis, Leandro Jose

AU - Heinekamp, T

AU - Rocha, MC

AU - Janevska, S

AU - Brakhage, AA

AU - Malavazi, I

AU - Goldman, GH

AU - Valiante, V

PY - 2019/4/30

Y1 - 2019/4/30

N2 - Aspergillus fumigatus is the most important airborne human pathogenic fungus, causing thousands of deaths per year. Its lethality is due to late and often inaccurate diagnosis and the lack of efficient therapeutics. The failure of efficient prophylaxis and therapy is based on the ability of this pathogen to activate numerous salvage pathways that are capable of overcoming the different drug-derived stresses. A major role in the protection of A. fumigatus is played by melanins. Melanins are cell wall-associated macromolecules classified as virulence determinants. The understanding of the various signaling pathways acting in this organism can be used to elucidate the mechanism beyond melanin production and help to identify ideal drug targets.

AB - Aspergillus fumigatus is the most important airborne human pathogenic fungus, causing thousands of deaths per year. Its lethality is due to late and often inaccurate diagnosis and the lack of efficient therapeutics. The failure of efficient prophylaxis and therapy is based on the ability of this pathogen to activate numerous salvage pathways that are capable of overcoming the different drug-derived stresses. A major role in the protection of A. fumigatus is played by melanins. Melanins are cell wall-associated macromolecules classified as virulence determinants. The understanding of the various signaling pathways acting in this organism can be used to elucidate the mechanism beyond melanin production and help to identify ideal drug targets.

U2 - 10.1128/mbio.00215-19

DO - 10.1128/mbio.00215-19

M3 - Article

SN - 2161-2129

VL - 10

JO - mBio

JF - mBio

IS - 2

ER -

Mitogen-Activated Protein Kinase Cross-Talk Interaction Modulates the Production of Melanins in Aspergillus fumigatus

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