Merlin, a multi-suppressor from cell membrane to the nucleus.

Lu Zhou; C. Oliver Hanemann

doi:10.1016/j.febslet.2012.03.016

Merlin, a multi-suppressor from cell membrane to the nucleus.

Lu Zhou, C. Oliver Hanemann^*

^*Corresponding author for this work

Peninsula Medical School

Research output: Contribution to journal › Article › peer-review

Abstract

Recent evidence suggests that the neurofibromatosis type 2 (NF2) gene encoded protein merlin suppresses mitogenic signalling not only at the cell membrane but also in the nucleus. At the membrane, merlin inhibits signalling by integrins and tyrosine receptor kinases (RTKs) and the activation of downstream pathways, including the Ras/Raf/MEK/ERK, FAK/Src, PI3K/AKT, Rac/PAK/JNK, mTORC1, and Wnt/β-catenin pathways. In the nucleus, merlin suppresses the E3 ubiquitin ligase CRL4(DCAF1) to inhibit proliferation. Gene expression analysis suggested that CRL4(DCAF1) could also regulate the expression of integrins and RTKs. In this review, we explore the links between merlin function at the membrane and in the nucleus, and discuss the potential of targeting the master regulator CRL4 (DCAF1) to treat NF2 and other merlin-deficient tumours.

Original language	English
Pages (from-to)	1403-1408
Number of pages	0
Journal	FEBS Lett
Volume	586
Issue number	10
DOIs	https://doi.org/10.1016/j.febslet.2012.03.016
Publication status	Published - 21 May 2012

Keywords

Animals
Cell Membrane
Cell Nucleus
Gene Expression Profiling
Humans
Integrins
Mice
Neurofibromin 2
Receptor Protein-Tyrosine Kinases
Signal Transduction
Ubiquitin-Protein Ligases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.febslet.2012.03.016

Cite this

@article{dad914bb40544da6be07f6ede17cc57c,

title = "Merlin, a multi-suppressor from cell membrane to the nucleus.",

abstract = "Recent evidence suggests that the neurofibromatosis type 2 (NF2) gene encoded protein merlin suppresses mitogenic signalling not only at the cell membrane but also in the nucleus. At the membrane, merlin inhibits signalling by integrins and tyrosine receptor kinases (RTKs) and the activation of downstream pathways, including the Ras/Raf/MEK/ERK, FAK/Src, PI3K/AKT, Rac/PAK/JNK, mTORC1, and Wnt/β-catenin pathways. In the nucleus, merlin suppresses the E3 ubiquitin ligase CRL4(DCAF1) to inhibit proliferation. Gene expression analysis suggested that CRL4(DCAF1) could also regulate the expression of integrins and RTKs. In this review, we explore the links between merlin function at the membrane and in the nucleus, and discuss the potential of targeting the master regulator CRL4 (DCAF1) to treat NF2 and other merlin-deficient tumours.",

keywords = "Animals, Cell Membrane, Cell Nucleus, Gene Expression Profiling, Humans, Integrins, Mice, Neurofibromin 2, Receptor Protein-Tyrosine Kinases, Signal Transduction, Ubiquitin-Protein Ligases",

author = "Lu Zhou and Hanemann, {C. Oliver}",

year = "2012",

month = may,

day = "21",

doi = "10.1016/j.febslet.2012.03.016",

language = "English",

volume = "586",

pages = "1403--1408",

journal = "FEBS Lett",

issn = "1873-3468",

number = "10",

}

TY - JOUR

T1 - Merlin, a multi-suppressor from cell membrane to the nucleus.

AU - Zhou, Lu

AU - Hanemann, C. Oliver

PY - 2012/5/21

Y1 - 2012/5/21

N2 - Recent evidence suggests that the neurofibromatosis type 2 (NF2) gene encoded protein merlin suppresses mitogenic signalling not only at the cell membrane but also in the nucleus. At the membrane, merlin inhibits signalling by integrins and tyrosine receptor kinases (RTKs) and the activation of downstream pathways, including the Ras/Raf/MEK/ERK, FAK/Src, PI3K/AKT, Rac/PAK/JNK, mTORC1, and Wnt/β-catenin pathways. In the nucleus, merlin suppresses the E3 ubiquitin ligase CRL4(DCAF1) to inhibit proliferation. Gene expression analysis suggested that CRL4(DCAF1) could also regulate the expression of integrins and RTKs. In this review, we explore the links between merlin function at the membrane and in the nucleus, and discuss the potential of targeting the master regulator CRL4 (DCAF1) to treat NF2 and other merlin-deficient tumours.

AB - Recent evidence suggests that the neurofibromatosis type 2 (NF2) gene encoded protein merlin suppresses mitogenic signalling not only at the cell membrane but also in the nucleus. At the membrane, merlin inhibits signalling by integrins and tyrosine receptor kinases (RTKs) and the activation of downstream pathways, including the Ras/Raf/MEK/ERK, FAK/Src, PI3K/AKT, Rac/PAK/JNK, mTORC1, and Wnt/β-catenin pathways. In the nucleus, merlin suppresses the E3 ubiquitin ligase CRL4(DCAF1) to inhibit proliferation. Gene expression analysis suggested that CRL4(DCAF1) could also regulate the expression of integrins and RTKs. In this review, we explore the links between merlin function at the membrane and in the nucleus, and discuss the potential of targeting the master regulator CRL4 (DCAF1) to treat NF2 and other merlin-deficient tumours.

KW - Animals

KW - Cell Membrane

KW - Cell Nucleus

KW - Gene Expression Profiling

KW - Humans

KW - Integrins

KW - Mice

KW - Neurofibromin 2

KW - Receptor Protein-Tyrosine Kinases

KW - Signal Transduction

KW - Ubiquitin-Protein Ligases

U2 - 10.1016/j.febslet.2012.03.016

DO - 10.1016/j.febslet.2012.03.016

M3 - Article

SN - 1873-3468

VL - 586

SP - 1403

EP - 1408

JO - FEBS Lett

JF - FEBS Lett

IS - 10

ER -

Merlin, a multi-suppressor from cell membrane to the nucleus.

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this