TY - JOUR
T1 - Mental Imagery to Reduce Alcohol-related harm in patients with alcohol use disorder and alcohol-related liver damaGE
T2 - the MIRAGE randomised pilot trial results
AU - Dhanda, Ashwin
AU - Andrade, Jackie
AU - Allende, Hannah
AU - Allgar, Victoria
AU - Bailey, Matthew
AU - Callaghan, Lynne
AU - Cocking, Laura
AU - Goodwin, Elizabeth
AU - Hawton, Annie
AU - Hayward, Christopher
AU - Hudson, Ben
AU - Ingram, Wendy
AU - Jeffery, Alison
AU - King, Angela
AU - Lavers, Victoria
AU - Lomax, Joe
AU - McCune, C Anne
AU - Musicha, Crispin
AU - Parker, Richard
AU - Rollinson, Christopher
AU - Wilks, Jonny
AU - Creanor, E Siobhan
N1 - © Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2024/1/29
Y1 - 2024/1/29
N2 - OBJECTIVE: The healthcare burden of alcohol-related liver disease (ARLD) is increasing. ARLD and alcohol use disorder (AUD) is best managed by reduction or cessation of alcohol use, but effective treatments are lacking. We tested whether people with ARLD and AUD admitted to hospital could be recruited to and retained in a trial of Functional Imagery Training (FIT), a psychological therapy that uses mental imagery to reduce alcohol craving. We conducted a multicentre randomised pilot trial of treatment as usual (TAU) versus FIT+TAU in people admitted to hospital with ARLD and AUD.DESIGN: Participants were randomised to TAU (a single session of brief intervention) or FIT+TAU (TAU with one hospital-based FIT session then eight telephone sessions over 6 months). Pilot outcomes included recruitment rate and retention at day 180. Secondary outcomes included fidelity of FIT delivery, alcohol use, and severity of alcohol dependence.RESULTS: Fifty-four participants (mean age 49; 63% male) were recruited and randomised, 28 to TAU and 26 to FIT+TAU. The retention rate at day 180 was 43%. FIT was delivered adequately by most alcohol nurses. 50% of intervention participants completed FIT sessions 1 and 2. There were no differences in alcohol use or severity of alcohol dependence between treatment groups at day 180.CONCLUSION: Participants with ARLD and AUD could be recruited to a trial of FIT versus FIT+TAU. However, retention at day 180 was suboptimal. Before conducting a definitive trial of FIT in this patient group, modifications in the intervention and recruitment/retention strategy must be tested.TRIAL REGISTRATION NUMBER: ISRCTN41353774.
AB - OBJECTIVE: The healthcare burden of alcohol-related liver disease (ARLD) is increasing. ARLD and alcohol use disorder (AUD) is best managed by reduction or cessation of alcohol use, but effective treatments are lacking. We tested whether people with ARLD and AUD admitted to hospital could be recruited to and retained in a trial of Functional Imagery Training (FIT), a psychological therapy that uses mental imagery to reduce alcohol craving. We conducted a multicentre randomised pilot trial of treatment as usual (TAU) versus FIT+TAU in people admitted to hospital with ARLD and AUD.DESIGN: Participants were randomised to TAU (a single session of brief intervention) or FIT+TAU (TAU with one hospital-based FIT session then eight telephone sessions over 6 months). Pilot outcomes included recruitment rate and retention at day 180. Secondary outcomes included fidelity of FIT delivery, alcohol use, and severity of alcohol dependence.RESULTS: Fifty-four participants (mean age 49; 63% male) were recruited and randomised, 28 to TAU and 26 to FIT+TAU. The retention rate at day 180 was 43%. FIT was delivered adequately by most alcohol nurses. 50% of intervention participants completed FIT sessions 1 and 2. There were no differences in alcohol use or severity of alcohol dependence between treatment groups at day 180.CONCLUSION: Participants with ARLD and AUD could be recruited to a trial of FIT versus FIT+TAU. However, retention at day 180 was suboptimal. Before conducting a definitive trial of FIT in this patient group, modifications in the intervention and recruitment/retention strategy must be tested.TRIAL REGISTRATION NUMBER: ISRCTN41353774.
KW - Humans
KW - Male
KW - Middle Aged
KW - Female
KW - Alcoholism/complications
KW - Pilot Projects
KW - Treatment Outcome
KW - Liver
UR - http://www.scopus.com/inward/record.url?scp=85183951485&partnerID=8YFLogxK
UR - https://pearl.plymouth.ac.uk/context/pms-research/article/2058/viewcontent/bmjgast_2023_001267.R1_authors_copy.pdf
U2 - 10.1136/bmjgast-2023-001267
DO - 10.1136/bmjgast-2023-001267
M3 - Article
C2 - 38286518
SN - 2054-4774
VL - 11
JO - BMJ Open Gastroenterology
JF - BMJ Open Gastroenterology
IS - 1
M1 - e001267
ER -
