Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors

Bertram Kjerulff; Joseph Dowsett; Rikke Louise Jacobsen; Josephine Gladov; Margit Hørup Larsen; Agnete Troen Lundgaard; Karina Banasik; David Westergaard; Susan Mikkelsen; Khoa Manh Dinh; Lotte Hindhede; Kathrine Agergård Kaspersen; Michael Schwinn; Anders Juul; Betina Poulsen; Birgitte Lindegaard; Carsten Bøcker Pedersen; Clive Eric Sabel; Henning Bundgaard; Henriette Svarre Nielsen; Janne Amstrup Møller; Jens Kjærgaard Boldsen; Kristoffer Sølvsten Burgdorf; Lars Vedel Kessing; Linda Jenny Handgaard; Lise Wegner Thørner; Maria Didriksen; Mette Nyegaard; Niels Grarup; Niels Ødum; Pär I. Johansson; Poul Jennum; Ruth Frikke-Schmidt; Sanne Schou Berger; Søren Brunak; Søren Jacobsen; Thomas Folkmann Hansen; Tine Kirkeskov Lundquist; Hansen Torben; Torben Lykke Sørensen; Torben Sigsgaard; Kaspar René Nielsen; Mie Topholm Bruun; Henrik Hjalgrim; Henrik Ullum; Klaus Rostgaard; Erik Sørensen; Ole Birger Pedersen; Sisse Rye Ostrowski; Christian Erikstrup

doi:10.1038/s43856-024-00474-2

Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors

Bertram Kjerulff^*, Joseph Dowsett, Rikke Louise Jacobsen, Josephine Gladov, Margit Hørup Larsen, Agnete Troen Lundgaard, Karina Banasik, David Westergaard, Susan Mikkelsen, Khoa Manh Dinh, Lotte Hindhede, Kathrine Agergård Kaspersen, Michael Schwinn, Anders Juul, Betina Poulsen, Birgitte Lindegaard, Carsten Bøcker Pedersen, Clive Eric Sabel, Henning Bundgaard, Henriette Svarre NielsenJanne Amstrup Møller, Jens Kjærgaard Boldsen, Kristoffer Sølvsten Burgdorf, Lars Vedel Kessing, Linda Jenny Handgaard, Lise Wegner Thørner, Maria Didriksen, Mette Nyegaard, Niels Grarup, Niels Ødum, Pär I. Johansson, Poul Jennum, Ruth Frikke-Schmidt, Sanne Schou Berger, Søren Brunak, Søren Jacobsen, Thomas Folkmann Hansen, Tine Kirkeskov Lundquist, Hansen Torben, Torben Lykke Sørensen, Torben Sigsgaard, Kaspar René Nielsen, Mie Topholm Bruun, Henrik Hjalgrim, Henrik Ullum, Klaus Rostgaard, Erik Sørensen, Ole Birger Pedersen, Sisse Rye Ostrowski, Christian Erikstrup

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Background The emerging use of biomarkers in research and tailored care introduces a need for information about the association between biomarkers and basic demographics and lifestyle factors revealing expectable concentrations in healthy individuals while considering general demographic differences. Methods A selection of 47 biomarkers, including markers of inflammation and vascular stress, were measured in plasma samples from 9876 Danish Blood Donor Study participants. Using regression models, we examined the association between biomarkers and sex, age, Body Mass Index (BMI), and smoking. Results Here we show that concentrations of inflammation and vascular stress biomarkers generally increase with higher age, BMI, and smoking. Sex-specific effects are observed for multiple biomarkers. Conclusion This study provides comprehensive information on concentrations of 47 plasma biomarkers in healthy individuals. The study emphasizes that knowledge about biomarker concentrations in healthy individuals is critical for improved understanding of disease pathology and for tailored care and decision support tools.

Original language	English
Article number	50
Pages (from-to)	50
Journal	Communications Medicine
Volume	4
Issue number	1
DOIs	https://doi.org/10.1038/s43856-024-00474-2
Publication status	Published - 16 Mar 2024

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Assessment and Diagnosis
Internal Medicine
Epidemiology
Medicine (miscellaneous)

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Kjerulff, B., Dowsett, J., Jacobsen, R. L., Gladov, J., Larsen, M. H., Lundgaard, A. T., Banasik, K., Westergaard, D., Mikkelsen, S., Dinh, K. M., Hindhede, L., Kaspersen, K. A., Schwinn, M., Juul, A., Poulsen, B., Lindegaard, B., Pedersen, C. B., Sabel, C. E., Bundgaard, H., ... Erikstrup, C. (2024). Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors. Communications Medicine, 4(1), 50. Article 50. https://doi.org/10.1038/s43856-024-00474-2

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title = "Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors",

abstract = "Background The emerging use of biomarkers in research and tailored care introduces a need for information about the association between biomarkers and basic demographics and lifestyle factors revealing expectable concentrations in healthy individuals while considering general demographic differences. Methods A selection of 47 biomarkers, including markers of inflammation and vascular stress, were measured in plasma samples from 9876 Danish Blood Donor Study participants. Using regression models, we examined the association between biomarkers and sex, age, Body Mass Index (BMI), and smoking. Results Here we show that concentrations of inflammation and vascular stress biomarkers generally increase with higher age, BMI, and smoking. Sex-specific effects are observed for multiple biomarkers. Conclusion This study provides comprehensive information on concentrations of 47 plasma biomarkers in healthy individuals. The study emphasizes that knowledge about biomarker concentrations in healthy individuals is critical for improved understanding of disease pathology and for tailored care and decision support tools.",

author = "Bertram Kjerulff and Joseph Dowsett and Jacobsen, {Rikke Louise} and Josephine Gladov and Larsen, {Margit H{\o}rup} and Lundgaard, {Agnete Troen} and Karina Banasik and David Westergaard and Susan Mikkelsen and Dinh, {Khoa Manh} and Lotte Hindhede and Kaspersen, {Kathrine Agerg{\aa}rd} and Michael Schwinn and Anders Juul and Betina Poulsen and Birgitte Lindegaard and Pedersen, {Carsten B{\o}cker} and Sabel, {Clive Eric} and Henning Bundgaard and Nielsen, {Henriette Svarre} and M{\o}ller, {Janne Amstrup} and Boldsen, {Jens Kj{\ae}rgaard} and Burgdorf, {Kristoffer S{\o}lvsten} and Kessing, {Lars Vedel} and Handgaard, {Linda Jenny} and Th{\o}rner, {Lise Wegner} and Maria Didriksen and Mette Nyegaard and Niels Grarup and Niels {\O}dum and Johansson, {P{\"a}r I.} and Poul Jennum and Ruth Frikke-Schmidt and Berger, {Sanne Schou} and S{\o}ren Brunak and S{\o}ren Jacobsen and Hansen, {Thomas Folkmann} and Lundquist, {Tine Kirkeskov} and Hansen Torben and S{\o}rensen, {Torben Lykke} and Torben Sigsgaard and Nielsen, {Kaspar Ren{\'e}} and Bruun, {Mie Topholm} and Henrik Hjalgrim and Henrik Ullum and Klaus Rostgaard and Erik S{\o}rensen and Pedersen, {Ole Birger} and Ostrowski, {Sisse Rye} and Christian Erikstrup",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = mar,

day = "16",

doi = "10.1038/s43856-024-00474-2",

language = "English",

volume = "4",

pages = "50",

journal = "Communications Medicine",

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Kjerulff, B, Dowsett, J, Jacobsen, RL, Gladov, J, Larsen, MH, Lundgaard, AT, Banasik, K, Westergaard, D, Mikkelsen, S, Dinh, KM, Hindhede, L, Kaspersen, KA, Schwinn, M, Juul, A, Poulsen, B, Lindegaard, B, Pedersen, CB, Sabel, CE, Bundgaard, H, Nielsen, HS, Møller, JA, Boldsen, JK, Burgdorf, KS, Kessing, LV, Handgaard, LJ, Thørner, LW, Didriksen, M, Nyegaard, M, Grarup, N, Ødum, N, Johansson, PI, Jennum, P, Frikke-Schmidt, R, Berger, SS, Brunak, S, Jacobsen, S, Hansen, TF, Lundquist, TK, Torben, H, Sørensen, TL, Sigsgaard, T, Nielsen, KR, Bruun, MT, Hjalgrim, H, Ullum, H, Rostgaard, K, Sørensen, E, Pedersen, OB, Ostrowski, SR & Erikstrup, C 2024, 'Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors', Communications Medicine, vol. 4, no. 1, 50, pp. 50. https://doi.org/10.1038/s43856-024-00474-2

TY - JOUR

T1 - Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors

AU - Kjerulff, Bertram

AU - Dowsett, Joseph

AU - Jacobsen, Rikke Louise

AU - Gladov, Josephine

AU - Larsen, Margit Hørup

AU - Lundgaard, Agnete Troen

AU - Banasik, Karina

AU - Westergaard, David

AU - Mikkelsen, Susan

AU - Dinh, Khoa Manh

AU - Hindhede, Lotte

AU - Kaspersen, Kathrine Agergård

AU - Schwinn, Michael

AU - Juul, Anders

AU - Poulsen, Betina

AU - Lindegaard, Birgitte

AU - Pedersen, Carsten Bøcker

AU - Sabel, Clive Eric

AU - Bundgaard, Henning

AU - Nielsen, Henriette Svarre

AU - Møller, Janne Amstrup

AU - Boldsen, Jens Kjærgaard

AU - Burgdorf, Kristoffer Sølvsten

AU - Kessing, Lars Vedel

AU - Handgaard, Linda Jenny

AU - Thørner, Lise Wegner

AU - Didriksen, Maria

AU - Nyegaard, Mette

AU - Grarup, Niels

AU - Ødum, Niels

AU - Johansson, Pär I.

AU - Jennum, Poul

AU - Frikke-Schmidt, Ruth

AU - Berger, Sanne Schou

AU - Brunak, Søren

AU - Jacobsen, Søren

AU - Hansen, Thomas Folkmann

AU - Lundquist, Tine Kirkeskov

AU - Torben, Hansen

AU - Sørensen, Torben Lykke

AU - Sigsgaard, Torben

AU - Nielsen, Kaspar René

AU - Bruun, Mie Topholm

AU - Hjalgrim, Henrik

AU - Ullum, Henrik

AU - Rostgaard, Klaus

AU - Sørensen, Erik

AU - Pedersen, Ole Birger

AU - Ostrowski, Sisse Rye

AU - Erikstrup, Christian

PY - 2024/3/16

Y1 - 2024/3/16

N2 - Background The emerging use of biomarkers in research and tailored care introduces a need for information about the association between biomarkers and basic demographics and lifestyle factors revealing expectable concentrations in healthy individuals while considering general demographic differences. Methods A selection of 47 biomarkers, including markers of inflammation and vascular stress, were measured in plasma samples from 9876 Danish Blood Donor Study participants. Using regression models, we examined the association between biomarkers and sex, age, Body Mass Index (BMI), and smoking. Results Here we show that concentrations of inflammation and vascular stress biomarkers generally increase with higher age, BMI, and smoking. Sex-specific effects are observed for multiple biomarkers. Conclusion This study provides comprehensive information on concentrations of 47 plasma biomarkers in healthy individuals. The study emphasizes that knowledge about biomarker concentrations in healthy individuals is critical for improved understanding of disease pathology and for tailored care and decision support tools.

AB - Background The emerging use of biomarkers in research and tailored care introduces a need for information about the association between biomarkers and basic demographics and lifestyle factors revealing expectable concentrations in healthy individuals while considering general demographic differences. Methods A selection of 47 biomarkers, including markers of inflammation and vascular stress, were measured in plasma samples from 9876 Danish Blood Donor Study participants. Using regression models, we examined the association between biomarkers and sex, age, Body Mass Index (BMI), and smoking. Results Here we show that concentrations of inflammation and vascular stress biomarkers generally increase with higher age, BMI, and smoking. Sex-specific effects are observed for multiple biomarkers. Conclusion This study provides comprehensive information on concentrations of 47 plasma biomarkers in healthy individuals. The study emphasizes that knowledge about biomarker concentrations in healthy individuals is critical for improved understanding of disease pathology and for tailored care and decision support tools.

UR - http://www.scopus.com/inward/record.url?scp=85193919225&partnerID=8YFLogxK

U2 - 10.1038/s43856-024-00474-2

DO - 10.1038/s43856-024-00474-2

M3 - Article

C2 - 38493237

AN - SCOPUS:85193919225

SN - 2730-664X

VL - 4

SP - 50

JO - Communications Medicine

JF - Communications Medicine

IS - 1

M1 - 50

ER -

Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors

Abstract

ASJC Scopus subject areas

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