Insights into nervous system repair from the fruit fly

David Coupe*, Torsten Bossing

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

<jats:title>Abstract</jats:title> <jats:p>Millions of people experience injury to the central nervous system (CNS) each year, many of whom are left permanently disabled, providing a challenging hurdle for the field of regenerative medicine. Repair of damage in the CNS occurs through a concerted effort of phagocytosis of debris, cell proliferation and differentiation to produce new neurons and glia, distal axon/dendrite degeneration, proximal axon/dendrite regeneration and axon re-enwrapment. In humans, regeneration is observed within the peripheral nervous system, while in the CNS injured axons exhibit limited ability to regenerate. This has also been described for the fruit fly Drosophila. Powerful genetic tools available in Drosophila have allowed the response to CNS insults to be probed and novel regulators with mammalian orthologs identified. The conservation of many regenerative pathways, despite considerable evolutionary separation, stresses that these signals are principal regulators and may serve as potential therapeutic targets. Here, we highlight the role of Drosophila CNS injury models in providing key insight into regenerative processes by exploring the underlying pathways that control glial and neuronal activation in response to insult, and their contribution to damage repair in the CNS.</jats:p>
Original languageEnglish
Number of pages0
JournalNeuronal Signaling
Volume6
Issue number1
Early online date13 Apr 2022
DOIs
Publication statusPublished - Apr 2022

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