Inhibition of nicotinamide nucleotide transhydrogenase in rat liver submitochondrial particles by dicyclohexylcarbodi-imide and butanedione.

AJ Moody; RA Reid

doi:10.1042/bj2090889

Inhibition of nicotinamide nucleotide transhydrogenase in rat liver submitochondrial particles by dicyclohexylcarbodi-imide and butanedione.

AJ Moody
, RA Reid

School of Biological and Marine Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Nicotinamide nucleotide transhydrogenase in rat liver submitochondrial particles is inhibited by treatment with NN'-dicyclohexylcarbodi-imide or butane-2,3-dione. Both inhibitions are pseudo-first-order with respect to enzyme activity. The reaction order with respect to inhibitor is close to unity for butanedione, but is significantly lower than unity for dicyclohexylcarbodi-imide.

Original language	English
Pages (from-to)	889-892
Number of pages	0
Journal	Biochem J
Volume	209
Issue number	3
DOIs	https://doi.org/10.1042/bj2090889
Publication status	Published - 1 Mar 1983

Keywords

Animals
Butanones
Carbodiimides
Diacetyl
Dicyclohexylcarbodiimide
In Vitro Techniques
Kinetics
Male
Mitochondria
Liver
NADH
NADPH Oxidoreductases
NADP Transhydrogenases
Rats
Inbred Strains
Submitochondrial Particles

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10.1042/bj2090889

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title = "Inhibition of nicotinamide nucleotide transhydrogenase in rat liver submitochondrial particles by dicyclohexylcarbodi-imide and butanedione.",

abstract = "Nicotinamide nucleotide transhydrogenase in rat liver submitochondrial particles is inhibited by treatment with NN'-dicyclohexylcarbodi-imide or butane-2,3-dione. Both inhibitions are pseudo-first-order with respect to enzyme activity. The reaction order with respect to inhibitor is close to unity for butanedione, but is significantly lower than unity for dicyclohexylcarbodi-imide.",

keywords = "Animals, Butanones, Carbodiimides, Diacetyl, Dicyclohexylcarbodiimide, In Vitro Techniques, Kinetics, Male, Mitochondria, Liver, NADH, NADPH Oxidoreductases, NADP Transhydrogenases, Rats, Inbred Strains, Submitochondrial Particles",

author = "AJ Moody and RA Reid",

year = "1983",

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doi = "10.1042/bj2090889",

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T1 - Inhibition of nicotinamide nucleotide transhydrogenase in rat liver submitochondrial particles by dicyclohexylcarbodi-imide and butanedione.

AU - Moody, AJ

AU - Reid, RA

PY - 1983/3/1

Y1 - 1983/3/1

N2 - Nicotinamide nucleotide transhydrogenase in rat liver submitochondrial particles is inhibited by treatment with NN'-dicyclohexylcarbodi-imide or butane-2,3-dione. Both inhibitions are pseudo-first-order with respect to enzyme activity. The reaction order with respect to inhibitor is close to unity for butanedione, but is significantly lower than unity for dicyclohexylcarbodi-imide.

AB - Nicotinamide nucleotide transhydrogenase in rat liver submitochondrial particles is inhibited by treatment with NN'-dicyclohexylcarbodi-imide or butane-2,3-dione. Both inhibitions are pseudo-first-order with respect to enzyme activity. The reaction order with respect to inhibitor is close to unity for butanedione, but is significantly lower than unity for dicyclohexylcarbodi-imide.

KW - Animals

KW - Butanones

KW - Carbodiimides

KW - Diacetyl

KW - Dicyclohexylcarbodiimide

KW - In Vitro Techniques

KW - Kinetics

KW - Male

KW - Mitochondria

KW - Liver

KW - NADH

KW - NADPH Oxidoreductases

KW - NADP Transhydrogenases

KW - Rats

KW - Inbred Strains

KW - Submitochondrial Particles

U2 - 10.1042/bj2090889

DO - 10.1042/bj2090889

M3 - Article

SN - 0264-6021

VL - 209

SP - 889

EP - 892

JO - Biochem J

JF - Biochem J

IS - 3

ER -

Inhibition of nicotinamide nucleotide transhydrogenase in rat liver submitochondrial particles by dicyclohexylcarbodi-imide and butanedione.

Abstract

Keywords

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