Increased expression of cyclin-D1 on trephine bone marrow biopsies independently predicts for shorter overall survival in patients with multiple myeloma treated with novel agents

Anna Tasidou; Maria Roussou; Evangelos Terpos; Efstathios Kastritis; Maria Gkotzamanidou; Maria Gavriatopoulou; Magdalini Migkou; Evangelos Eleutherakis-Papaiakovou; Nikitas Nikitas; Dimitra Anagnostou; Meletios A. Dimopoulos

doi:10.1002/ajh.23223

Increased expression of cyclin-D1 on trephine bone marrow biopsies independently predicts for shorter overall survival in patients with multiple myeloma treated with novel agents

Anna Tasidou
, Maria Roussou
, Evangelos Terpos
, Efstathios Kastritis
, Maria Gkotzamanidou
, Maria Gavriatopoulou
, Magdalini Migkou
, Evangelos Eleutherakis-Papaiakovou
, Nikitas Nikitas
, Dimitra Anagnostou
, Meletios A. Dimopoulos^*

^*Corresponding author for this work

Evagelismos Hospital
National and Kapodistrian University of Athens

Research output: Contribution to journal › Letter › peer-review

Abstract

Multiple myeloma (MM) comprises 1% of all malignancies and 13% of hematological malignancies in the Caucasian population. Yearly incidence is 4/100,000 in the US and is higher in blacks and males [1]. The pathogenesis of the disease is relatively unknown; several chromosomal abnormalities have been related to the development of the disease, but none is characteristic of MM. Cyclin-D1 is a protein encoded by the CCND1 (bcl-1) gene on chromosome 11q13, and is an important regulator of G1 to S phase progression.

Original language	English
Pages (from-to)	734-736
Number of pages	3
Journal	American Journal of Hematology
Volume	87
Issue number	7
DOIs	https://doi.org/10.1002/ajh.23223
Publication status	Published - Jul 2012
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Hematology

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10.1002/ajh.23223

Cite this

Tasidou, A., Roussou, M., Terpos, E., Kastritis, E., Gkotzamanidou, M., Gavriatopoulou, M., Migkou, M., Eleutherakis-Papaiakovou, E., Nikitas, N., Anagnostou, D., & Dimopoulos, M. A. (2012). Increased expression of cyclin-D1 on trephine bone marrow biopsies independently predicts for shorter overall survival in patients with multiple myeloma treated with novel agents. American Journal of Hematology, 87(7), 734-736. https://doi.org/10.1002/ajh.23223

@article{36c6b715e472425db457592b07f8f3a9,

title = "Increased expression of cyclin-D1 on trephine bone marrow biopsies independently predicts for shorter overall survival in patients with multiple myeloma treated with novel agents",

abstract = "Multiple myeloma (MM) comprises 1\% of all malignancies and 13\% of hematological malignancies in the Caucasian population. Yearly incidence is 4/100,000 in the US and is higher in blacks and males [1]. The pathogenesis of the disease is relatively unknown; several chromosomal abnormalities have been related to the development of the disease, but none is characteristic of MM. Cyclin-D1 is a protein encoded by the CCND1 (bcl-1) gene on chromosome 11q13, and is an important regulator of G1 to S phase progression.",

author = "Anna Tasidou and Maria Roussou and Evangelos Terpos and Efstathios Kastritis and Maria Gkotzamanidou and Maria Gavriatopoulou and Magdalini Migkou and Evangelos Eleutherakis-Papaiakovou and Nikitas Nikitas and Dimitra Anagnostou and Dimopoulos, \{Meletios A.\}",

year = "2012",

month = jul,

doi = "10.1002/ajh.23223",

language = "English",

volume = "87",

pages = "734--736",

journal = "American Journal of Hematology",

issn = "0361-8609",

publisher = "John Wiley and Sons Inc.",

number = "7",

}

Tasidou, A, Roussou, M, Terpos, E, Kastritis, E, Gkotzamanidou, M, Gavriatopoulou, M, Migkou, M, Eleutherakis-Papaiakovou, E, Nikitas, N, Anagnostou, D & Dimopoulos, MA 2012, 'Increased expression of cyclin-D1 on trephine bone marrow biopsies independently predicts for shorter overall survival in patients with multiple myeloma treated with novel agents', American Journal of Hematology, vol. 87, no. 7, pp. 734-736. https://doi.org/10.1002/ajh.23223

Increased expression of cyclin-D1 on trephine bone marrow biopsies independently predicts for shorter overall survival in patients with multiple myeloma treated with novel agents. / Tasidou, Anna; Roussou, Maria; Terpos, Evangelos et al.
In: American Journal of Hematology, Vol. 87, No. 7, 07.2012, p. 734-736.

Research output: Contribution to journal › Letter › peer-review

TY - JOUR

T1 - Increased expression of cyclin-D1 on trephine bone marrow biopsies independently predicts for shorter overall survival in patients with multiple myeloma treated with novel agents

AU - Tasidou, Anna

AU - Roussou, Maria

AU - Terpos, Evangelos

AU - Kastritis, Efstathios

AU - Gkotzamanidou, Maria

AU - Gavriatopoulou, Maria

AU - Migkou, Magdalini

AU - Eleutherakis-Papaiakovou, Evangelos

AU - Nikitas, Nikitas

AU - Anagnostou, Dimitra

AU - Dimopoulos, Meletios A.

PY - 2012/7

Y1 - 2012/7

N2 - Multiple myeloma (MM) comprises 1% of all malignancies and 13% of hematological malignancies in the Caucasian population. Yearly incidence is 4/100,000 in the US and is higher in blacks and males [1]. The pathogenesis of the disease is relatively unknown; several chromosomal abnormalities have been related to the development of the disease, but none is characteristic of MM. Cyclin-D1 is a protein encoded by the CCND1 (bcl-1) gene on chromosome 11q13, and is an important regulator of G1 to S phase progression.

AB - Multiple myeloma (MM) comprises 1% of all malignancies and 13% of hematological malignancies in the Caucasian population. Yearly incidence is 4/100,000 in the US and is higher in blacks and males [1]. The pathogenesis of the disease is relatively unknown; several chromosomal abnormalities have been related to the development of the disease, but none is characteristic of MM. Cyclin-D1 is a protein encoded by the CCND1 (bcl-1) gene on chromosome 11q13, and is an important regulator of G1 to S phase progression.

UR - https://www.scopus.com/pages/publications/84862510109

U2 - 10.1002/ajh.23223

DO - 10.1002/ajh.23223

M3 - Letter

C2 - 22565393

AN - SCOPUS:84862510109

SN - 0361-8609

VL - 87

SP - 734

EP - 736

JO - American Journal of Hematology

JF - American Journal of Hematology

IS - 7

ER -

Increased expression of cyclin-D1 on trephine bone marrow biopsies independently predicts for shorter overall survival in patients with multiple myeloma treated with novel agents

Abstract

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ASJC Scopus subject areas

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