TY - JOUR
T1 - Increased expression of cyclin-D1 on trephine bone marrow biopsies independently predicts for shorter overall survival in patients with multiple myeloma treated with novel agents
AU - Tasidou, Anna
AU - Roussou, Maria
AU - Terpos, Evangelos
AU - Kastritis, Efstathios
AU - Gkotzamanidou, Maria
AU - Gavriatopoulou, Maria
AU - Migkou, Magdalini
AU - Eleutherakis-Papaiakovou, Evangelos
AU - Nikitas, Nikitas
AU - Anagnostou, Dimitra
AU - Dimopoulos, Meletios A.
PY - 2012/7
Y1 - 2012/7
N2 - Multiple myeloma (MM) comprises 1% of all malignancies and 13% of hematological malignancies in the Caucasian population. Yearly incidence is 4/100,000 in the US and is higher in blacks and males [1]. The pathogenesis of the disease is relatively unknown; several chromosomal abnormalities have been related to the development of the disease, but none is characteristic of MM. Cyclin-D1 is a protein encoded by the CCND1 (bcl-1) gene on chromosome 11q13, and is an important regulator of G1 to S phase progression.
AB - Multiple myeloma (MM) comprises 1% of all malignancies and 13% of hematological malignancies in the Caucasian population. Yearly incidence is 4/100,000 in the US and is higher in blacks and males [1]. The pathogenesis of the disease is relatively unknown; several chromosomal abnormalities have been related to the development of the disease, but none is characteristic of MM. Cyclin-D1 is a protein encoded by the CCND1 (bcl-1) gene on chromosome 11q13, and is an important regulator of G1 to S phase progression.
UR - https://www.scopus.com/pages/publications/84862510109
U2 - 10.1002/ajh.23223
DO - 10.1002/ajh.23223
M3 - Letter
C2 - 22565393
AN - SCOPUS:84862510109
SN - 0361-8609
VL - 87
SP - 734
EP - 736
JO - American Journal of Hematology
JF - American Journal of Hematology
IS - 7
ER -
