Incorporation of vitamin E in poly(3hydroxybutyrate)/Bioglass composite films: effect on surface properties and cell attachment.

Superb K. Misra, Sheryl E. Philip, Wojciech Chrzanowski, Showan N. Nazhat, Ipsita Roy, Jonathan C. Knowles, Vehid Salih, Aldo R. Boccaccini

Research output: Contribution to journalArticlepeer-review

Abstract

This study investigated the possibility of incorporating alpha-tocopherol (vitamin E) into poly(3hydroxybutyrate) (P(3HB))/Bioglass composites, which are being developed for bone tissue engineering matrices. P(3HB) films with 20 wt% Bioglass and 10 wt% vitamin E were prepared using the solvent casting technique. Addition of vitamin E significantly improved the hydrophilicity of the composites along with increasing the total protein adsorption. The presence of protein adsorbed on the composite surface was further confirmed using X-ray photoelectron spectroscopy analysis. Preliminary cell culture studies using MG-63 human osteoblasts showed that the addition of vitamin E in the P(3HB)/20 wt% Bioglass films significantly increased cell proliferation. The results achieved in this study confirmed the possibility of incorporating vitamin E as a suitable additive in P(3HB)/Bioglass composites to engineer the surface of the composites by promoting higher protein adsorption and increasing the hydrophilicity.
Original languageEnglish
Pages (from-to)401-409
Number of pages0
JournalJ R Soc Interface
Volume6
Issue number33
DOIs
Publication statusPublished - 6 Apr 2009

Keywords

  • Adsorption
  • Animals
  • Antioxidants
  • Blood Proteins
  • Cattle
  • Cell Adhesion
  • Cell Growth Processes
  • Cell Line
  • Tumor
  • Ceramics
  • Humans
  • Hydroxybutyrates
  • Microscopy
  • Electron
  • Scanning
  • Osteoblasts
  • Polyesters
  • Surface Properties
  • Tissue Engineering
  • Vitamin E

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