IFN-λ3, not IFN-λ4, likely mediates IFNL3-IFNL4 haplotype-dependent hepatic inflammation and fibrosis

Mohammed Eslam; Duncan McLeod; Kebitsaone Simon Kelaeng; Alessandra Mangia; Thomas Berg; Khaled Thabet; William L. Irving; Gregory J. Dore; David Sheridan; Henning Grønbæk; Maria Lorena Abate; Rune Hartmann; Elisabetta Bugianesi; Ulrich Spengler; Angela Rojas; David R. Booth; Martin Weltman; Lindsay Mollison; Wendy Cheng; Stephen Riordan; H Mahajan; Janett Fischer; Jacob Nattermann; Mark W. Douglas; Christopher Liddle; Elizabeth Powell; Manuel Romero-Gomez; Jacob George; Mayada Metwally; Rose White; Rocio Gallego-Duran; Reynold Leung; N Mahajan; Margaret Bassendine; Antony Rahme; Chiara Rosso; Lavinia Mezzabotta; Barbara Malik; Gail Matthews; Anastasia Asimakopoulos; Tanya Applegate; Jason Grebely; Vincenzo Fragomeli; Julie R. Jonsson; Rosanna Santoro

doi:10.1038/ng.3836

IFN-λ3, not IFN-λ4, likely mediates IFNL3-IFNL4 haplotype-dependent hepatic inflammation and fibrosis

Mohammed Eslam
, Duncan McLeod
, Kebitsaone Simon Kelaeng
, Alessandra Mangia
, Thomas Berg
, Khaled Thabet
, William L. Irving
, Gregory J. Dore
, David Sheridan
, Henning Grønbæk
, Maria Lorena Abate
, Rune Hartmann
, Elisabetta Bugianesi
, Ulrich Spengler
, Angela Rojas
, David R. Booth
, Martin Weltman
, Lindsay Mollison
, Wendy Cheng
, Stephen Riordan

H Mahajan, Janett Fischer, Jacob Nattermann, Mark W. Douglas, Christopher Liddle, Elizabeth Powell, Manuel Romero-Gomez, Jacob George^*, Mayada Metwally, Rose White, Rocio Gallego-Duran, Reynold Leung, N Mahajan, Margaret Bassendine, Antony Rahme, Chiara Rosso, Lavinia Mezzabotta, Barbara Malik, Gail Matthews, Anastasia Asimakopoulos, Tanya Applegate, Jason Grebely, Vincenzo Fragomeli, Julie R. Jonsson, Rosanna Santoro

^*Corresponding author for this work

Peninsula Medical School

University of Sydney
Westmead Hospital
IRCCS Ospedale Casa Sollievo della Sofferenza - San Giovanni Rotondo (FG)
Leipzig University
Minia University
University of Nottingham
University of New South Wales
Aarhus University
University of Turin
University of Bonn
Hospital Universitario Virgen del Rocio
Nepean Hospital
Fremantle Hospital
Royal Perth Hospital
University of Queensland

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Original language	English
Pages (from-to)	795-800
Number of pages	0
Journal	Nature Genetics
Volume	49
Issue number	5
Early online date	10 Apr 2017
DOIs	https://doi.org/10.1038/ng.3836
Publication status	Published - 10 Apr 2017

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Eslam, M., McLeod, D., Kelaeng, K. S., Mangia, A., Berg, T., Thabet, K., Irving, W. L., Dore, G. J., Sheridan, D., Grønbæk, H., Abate, M. L., Hartmann, R., Bugianesi, E., Spengler, U., Rojas, A., Booth, D. R., Weltman, M., Mollison, L., Cheng, W., ... Santoro, R. (2017). IFN-λ3, not IFN-λ4, likely mediates IFNL3-IFNL4 haplotype-dependent hepatic inflammation and fibrosis. Nature Genetics, 49(5), 795-800. https://doi.org/10.1038/ng.3836

@article{15e860c9c8474313b7e69bc6ed621852,

title = "IFN-λ3, not IFN-λ4, likely mediates IFNL3-IFNL4 haplotype-dependent hepatic inflammation and fibrosis",

author = "Mohammed Eslam and Duncan McLeod and Kelaeng, \{Kebitsaone Simon\} and Alessandra Mangia and Thomas Berg and Khaled Thabet and Irving, \{William L.\} and Dore, \{Gregory J.\} and David Sheridan and Henning Gr{\o}nb{\ae}k and Abate, \{Maria Lorena\} and Rune Hartmann and Elisabetta Bugianesi and Ulrich Spengler and Angela Rojas and Booth, \{David R.\} and Martin Weltman and Lindsay Mollison and Wendy Cheng and Stephen Riordan and H Mahajan and Janett Fischer and Jacob Nattermann and Douglas, \{Mark W.\} and Christopher Liddle and Elizabeth Powell and Manuel Romero-Gomez and Jacob George and Mayada Metwally and Rose White and Rocio Gallego-Duran and Reynold Leung and N Mahajan and Margaret Bassendine and Antony Rahme and Chiara Rosso and Lavinia Mezzabotta and Barbara Malik and Gail Matthews and Anastasia Asimakopoulos and Tanya Applegate and Jason Grebely and Vincenzo Fragomeli and Jonsson, \{Julie R.\} and Rosanna Santoro",

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doi = "10.1038/ng.3836",

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Eslam, M, McLeod, D, Kelaeng, KS, Mangia, A, Berg, T, Thabet, K, Irving, WL, Dore, GJ, Sheridan, D, Grønbæk, H, Abate, ML, Hartmann, R, Bugianesi, E, Spengler, U, Rojas, A, Booth, DR, Weltman, M, Mollison, L, Cheng, W, Riordan, S, Mahajan, H, Fischer, J, Nattermann, J, Douglas, MW, Liddle, C, Powell, E, Romero-Gomez, M, George, J, Metwally, M, White, R, Gallego-Duran, R, Leung, R, Mahajan, N, Bassendine, M, Rahme, A, Rosso, C, Mezzabotta, L, Malik, B, Matthews, G, Asimakopoulos, A, Applegate, T, Grebely, J, Fragomeli, V, Jonsson, JR & Santoro, R 2017, 'IFN-λ3, not IFN-λ4, likely mediates IFNL3-IFNL4 haplotype-dependent hepatic inflammation and fibrosis', Nature Genetics, vol. 49, no. 5, pp. 795-800. https://doi.org/10.1038/ng.3836

TY - JOUR

T1 - IFN-λ3, not IFN-λ4, likely mediates IFNL3-IFNL4 haplotype-dependent hepatic inflammation and fibrosis

AU - Eslam, Mohammed

AU - McLeod, Duncan

AU - Kelaeng, Kebitsaone Simon

AU - Mangia, Alessandra

AU - Berg, Thomas

AU - Thabet, Khaled

AU - Irving, William L.

AU - Dore, Gregory J.

AU - Sheridan, David

AU - Grønbæk, Henning

AU - Abate, Maria Lorena

AU - Hartmann, Rune

AU - Bugianesi, Elisabetta

AU - Spengler, Ulrich

AU - Rojas, Angela

AU - Booth, David R.

AU - Weltman, Martin

AU - Mollison, Lindsay

AU - Cheng, Wendy

AU - Riordan, Stephen

AU - Mahajan, H

AU - Fischer, Janett

AU - Nattermann, Jacob

AU - Douglas, Mark W.

AU - Liddle, Christopher

AU - Powell, Elizabeth

AU - Romero-Gomez, Manuel

AU - George, Jacob

AU - Metwally, Mayada

AU - White, Rose

AU - Gallego-Duran, Rocio

AU - Leung, Reynold

AU - Mahajan, N

AU - Bassendine, Margaret

AU - Rahme, Antony

AU - Rosso, Chiara

AU - Mezzabotta, Lavinia

AU - Malik, Barbara

AU - Matthews, Gail

AU - Asimakopoulos, Anastasia

AU - Applegate, Tanya

AU - Grebely, Jason

AU - Fragomeli, Vincenzo

AU - Jonsson, Julie R.

AU - Santoro, Rosanna

PY - 2017/4/10

Y1 - 2017/4/10

UR - https://pearl.plymouth.ac.uk/pms-research/107/

U2 - 10.1038/ng.3836

DO - 10.1038/ng.3836

M3 - Article

SN - 1061-4036

VL - 49

SP - 795

EP - 800

JO - Nature Genetics

JF - Nature Genetics

IS - 5

ER -

IFN-λ3, not IFN-λ4, likely mediates IFNL3-IFNL4 haplotype-dependent hepatic inflammation and fibrosis

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