HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection.

Salim I. Khakoo; Chloe L. Thio; Maureen P. Martin; Collin R. Brooks; Xiaojiang Gao; Jacquie Astemborski; Jie Cheng; James J. Goedert; David Vlahov; Margaret Hilgartner; Steven Cox; Ann Margeret Little; Graeme J. Alexander; Matthew E. Cramp; Stephen J. O'Brien; William M.C. Rosenberg; David L. Thomas; Mary Carrington

doi:10.1126/science.1097670

HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection.

Salim I. Khakoo^*, Chloe L. Thio, Maureen P. Martin, Collin R. Brooks, Xiaojiang Gao, Jacquie Astemborski, Jie Cheng, James J. Goedert, David Vlahov, Margaret Hilgartner, Steven Cox, Ann Margeret Little, Graeme J. Alexander, Matthew E. Cramp, Stephen J. O'Brien, William M.C. Rosenberg, David L. Thomas, Mary Carrington

^*Corresponding author for this work

Peninsula Medical School

Research output: Contribution to journal › Article › peer-review

Abstract

Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for major histocompatibility complex class I molecules as a means of controlling their activity. We show that genes encoding the inhibitory NK cell receptor KIR2DL3 and its human leukocyte antigen C group 1 (HLA-C1) ligand directly influence resolution of hepatitis C virus (HCV) infection. This effect was observed in Caucasians and African Americans with expected low infectious doses of HCV but not in those with high-dose exposure, in whom the innate immune response is likely overwhelmed. The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV.

Original language	English
Pages (from-to)	872-874
Number of pages	0
Journal	Science
Volume	305
Issue number	5685
DOIs	https://doi.org/10.1126/science.1097670
Publication status	Published - 6 Aug 2004

Keywords

Adolescent
Adult
Black or African American
Alleles
Blood Transfusion
Child
Cohort Studies
Female
HLA-C Antigens
Hepacivirus
Hepatitis C
Homozygote
Humans
Killer Cells
Natural
Ligands
Male
Receptors
Immunologic
KIR
KIR2DL1
KIR2DL3
Regression Analysis
White People

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1126/science.1097670

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Khakoo, S. I., Thio, C. L., Martin, M. P., Brooks, C. R., Gao, X., Astemborski, J., Cheng, J., Goedert, J. J., Vlahov, D., Hilgartner, M., Cox, S., Little, A. M., Alexander, G. J., Cramp, M. E., O'Brien, S. J., Rosenberg, W. M. C., Thomas, D. L., & Carrington, M. (2004). HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection. Science, 305(5685), 872-874. https://doi.org/10.1126/science.1097670

@article{981cbafea8ca4667a67abf95ce259d9e,

title = "HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection.",

abstract = "Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for major histocompatibility complex class I molecules as a means of controlling their activity. We show that genes encoding the inhibitory NK cell receptor KIR2DL3 and its human leukocyte antigen C group 1 (HLA-C1) ligand directly influence resolution of hepatitis C virus (HCV) infection. This effect was observed in Caucasians and African Americans with expected low infectious doses of HCV but not in those with high-dose exposure, in whom the innate immune response is likely overwhelmed. The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV.",

keywords = "Adolescent, Adult, Black or African American, Alleles, Blood Transfusion, Child, Cohort Studies, Female, HLA-C Antigens, Hepacivirus, Hepatitis C, Homozygote, Humans, Killer Cells, Natural, Ligands, Male, Receptors, Immunologic, KIR, KIR2DL1, KIR2DL3, Regression Analysis, White People",

author = "Khakoo, {Salim I.} and Thio, {Chloe L.} and Martin, {Maureen P.} and Brooks, {Collin R.} and Xiaojiang Gao and Jacquie Astemborski and Jie Cheng and Goedert, {James J.} and David Vlahov and Margaret Hilgartner and Steven Cox and Little, {Ann Margeret} and Alexander, {Graeme J.} and Cramp, {Matthew E.} and O'Brien, {Stephen J.} and Rosenberg, {William M.C.} and Thomas, {David L.} and Mary Carrington",

year = "2004",

month = aug,

day = "6",

doi = "10.1126/science.1097670",

language = "English",

volume = "305",

pages = "872--874",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5685",

}

Khakoo, SI, Thio, CL, Martin, MP, Brooks, CR, Gao, X, Astemborski, J, Cheng, J, Goedert, JJ, Vlahov, D, Hilgartner, M, Cox, S, Little, AM, Alexander, GJ, Cramp, ME, O'Brien, SJ, Rosenberg, WMC, Thomas, DL & Carrington, M 2004, 'HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection.', Science, vol. 305, no. 5685, pp. 872-874. https://doi.org/10.1126/science.1097670

TY - JOUR

T1 - HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection.

AU - Khakoo, Salim I.

AU - Thio, Chloe L.

AU - Martin, Maureen P.

AU - Brooks, Collin R.

AU - Gao, Xiaojiang

AU - Astemborski, Jacquie

AU - Cheng, Jie

AU - Goedert, James J.

AU - Vlahov, David

AU - Hilgartner, Margaret

AU - Cox, Steven

AU - Little, Ann Margeret

AU - Alexander, Graeme J.

AU - Cramp, Matthew E.

AU - O'Brien, Stephen J.

AU - Rosenberg, William M.C.

AU - Thomas, David L.

AU - Carrington, Mary

PY - 2004/8/6

Y1 - 2004/8/6

N2 - Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for major histocompatibility complex class I molecules as a means of controlling their activity. We show that genes encoding the inhibitory NK cell receptor KIR2DL3 and its human leukocyte antigen C group 1 (HLA-C1) ligand directly influence resolution of hepatitis C virus (HCV) infection. This effect was observed in Caucasians and African Americans with expected low infectious doses of HCV but not in those with high-dose exposure, in whom the innate immune response is likely overwhelmed. The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV.

AB - Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for major histocompatibility complex class I molecules as a means of controlling their activity. We show that genes encoding the inhibitory NK cell receptor KIR2DL3 and its human leukocyte antigen C group 1 (HLA-C1) ligand directly influence resolution of hepatitis C virus (HCV) infection. This effect was observed in Caucasians and African Americans with expected low infectious doses of HCV but not in those with high-dose exposure, in whom the innate immune response is likely overwhelmed. The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV.

KW - Adolescent

KW - Adult

KW - Black or African American

KW - Alleles

KW - Blood Transfusion

KW - Child

KW - Cohort Studies

KW - Female

KW - HLA-C Antigens

KW - Hepacivirus

KW - Hepatitis C

KW - Homozygote

KW - Humans

KW - Killer Cells

KW - Natural

KW - Ligands

KW - Male

KW - Receptors

KW - Immunologic

KW - KIR

KW - KIR2DL1

KW - KIR2DL3

KW - Regression Analysis

KW - White People

U2 - 10.1126/science.1097670

DO - 10.1126/science.1097670

M3 - Article

SN - 0036-8075

VL - 305

SP - 872

EP - 874

JO - Science

JF - Science

IS - 5685

ER -

HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection.

Abstract

Keywords

UN SDGs

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