Hepatitis GB virus-C/hepatitis G virus infection in liver disease

Ikuo Nagata; Nikos Tzampouras; Shilpa Chokshi; Nikolai V. Naoumov; Paul Cheeseman; Heather M. Smith; Alastair J. Baker; Roger Williams; Giorgina Mieli-Vergani

doi:10.1136/adc.77.3.223

Hepatitis GB virus-C/hepatitis G virus infection in liver disease

Ikuo Nagata, Nikos Tzampouras, Shilpa Chokshi, Nikolai V. Naoumov, Paul Cheeseman, Heather M. Smith, Alastair J. Baker^*, Roger Williams, Giorgina Mieli-Vergani

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Hepatitis GB virus-C (HGBV-C)/hepatitis G virus (HGV) infection was investigated in 106 children with liver disease (54 boys and 52 girls, mean age 7.3 years); 12 with chronic hepatitis C virus infection, 29 with positive hepatitis B surface antigen, nine with idiopathic fulminant hepatic failure, seven with graft dysfunction after liver transplantation associated with autoimmune features, 20 with cryptogenic liver disease, and 29 with autoimmune liver disease. HGV RNA detected by reverse transcription polymerase chain reaction was found to be positive in 4/106 patients (3.8%). Risk factors were identified in three patients, including blood transfusion and/or medical treatment in Eastern Europe. The prevalence was higher than that of blood donors but lower than that of 2 adult patients with liver disease. HGV is not associated with any specific disease group and does not seem to be a major aetiological agent of liver disease in childhood in the UK.

Original language	English
Pages (from-to)	223-226
Number of pages	4
Journal	Archives of Disease in Childhood
Volume	77
Issue number	3
DOIs	https://doi.org/10.1136/adc.77.3.223
Publication status	Published - 1997
Externally published	Yes

ASJC Scopus subject areas

Pediatrics, Perinatology and Child Health

Keywords

Epidemiology
Hepatitis G virus
Routes of infection

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/adc.77.3.223

Cite this

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title = "Hepatitis GB virus-C/hepatitis G virus infection in liver disease",

abstract = "Hepatitis GB virus-C (HGBV-C)/hepatitis G virus (HGV) infection was investigated in 106 children with liver disease (54 boys and 52 girls, mean age 7.3 years); 12 with chronic hepatitis C virus infection, 29 with positive hepatitis B surface antigen, nine with idiopathic fulminant hepatic failure, seven with graft dysfunction after liver transplantation associated with autoimmune features, 20 with cryptogenic liver disease, and 29 with autoimmune liver disease. HGV RNA detected by reverse transcription polymerase chain reaction was found to be positive in 4/106 patients (3.8%). Risk factors were identified in three patients, including blood transfusion and/or medical treatment in Eastern Europe. The prevalence was higher than that of blood donors but lower than that of 2 adult patients with liver disease. HGV is not associated with any specific disease group and does not seem to be a major aetiological agent of liver disease in childhood in the UK.",

keywords = "Epidemiology, Hepatitis G virus, Routes of infection",

author = "Ikuo Nagata and Nikos Tzampouras and Shilpa Chokshi and Naoumov, {Nikolai V.} and Paul Cheeseman and Smith, {Heather M.} and Baker, {Alastair J.} and Roger Williams and Giorgina Mieli-Vergani",

year = "1997",

doi = "10.1136/adc.77.3.223",

language = "English",

volume = "77",

pages = "223--226",

journal = "Archives of Disease in Childhood",

issn = "0003-9888",

publisher = "BMJ Publishing Group",

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T1 - Hepatitis GB virus-C/hepatitis G virus infection in liver disease

AU - Nagata, Ikuo

AU - Tzampouras, Nikos

AU - Chokshi, Shilpa

AU - Naoumov, Nikolai V.

AU - Cheeseman, Paul

AU - Smith, Heather M.

AU - Baker, Alastair J.

AU - Williams, Roger

AU - Mieli-Vergani, Giorgina

PY - 1997

Y1 - 1997

N2 - Hepatitis GB virus-C (HGBV-C)/hepatitis G virus (HGV) infection was investigated in 106 children with liver disease (54 boys and 52 girls, mean age 7.3 years); 12 with chronic hepatitis C virus infection, 29 with positive hepatitis B surface antigen, nine with idiopathic fulminant hepatic failure, seven with graft dysfunction after liver transplantation associated with autoimmune features, 20 with cryptogenic liver disease, and 29 with autoimmune liver disease. HGV RNA detected by reverse transcription polymerase chain reaction was found to be positive in 4/106 patients (3.8%). Risk factors were identified in three patients, including blood transfusion and/or medical treatment in Eastern Europe. The prevalence was higher than that of blood donors but lower than that of 2 adult patients with liver disease. HGV is not associated with any specific disease group and does not seem to be a major aetiological agent of liver disease in childhood in the UK.

AB - Hepatitis GB virus-C (HGBV-C)/hepatitis G virus (HGV) infection was investigated in 106 children with liver disease (54 boys and 52 girls, mean age 7.3 years); 12 with chronic hepatitis C virus infection, 29 with positive hepatitis B surface antigen, nine with idiopathic fulminant hepatic failure, seven with graft dysfunction after liver transplantation associated with autoimmune features, 20 with cryptogenic liver disease, and 29 with autoimmune liver disease. HGV RNA detected by reverse transcription polymerase chain reaction was found to be positive in 4/106 patients (3.8%). Risk factors were identified in three patients, including blood transfusion and/or medical treatment in Eastern Europe. The prevalence was higher than that of blood donors but lower than that of 2 adult patients with liver disease. HGV is not associated with any specific disease group and does not seem to be a major aetiological agent of liver disease in childhood in the UK.

KW - Epidemiology

KW - Hepatitis G virus

KW - Routes of infection

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U2 - 10.1136/adc.77.3.223

DO - 10.1136/adc.77.3.223

M3 - Article

AN - SCOPUS:0030812858

SN - 0003-9888

VL - 77

SP - 223

EP - 226

JO - Archives of Disease in Childhood

JF - Archives of Disease in Childhood

IS - 3

ER -

Hepatitis GB virus-C/hepatitis G virus infection in liver disease

Abstract

ASJC Scopus subject areas

Keywords

UN SDGs

Access to Document

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