TY - JOUR
T1 - Health related quality of life in older patients with solid tumors and prognostic factors for decline
AU - Decoster, Lore
AU - Quinten, Chantal
AU - Kenis, Cindy
AU - Flamaing, Johan
AU - Debruyne, Philip R.
AU - De Groof, Inge
AU - Focan, Christian
AU - Cornelis, Frank
AU - Verschaeve, Vincent
AU - Bachmann, Christian
AU - Bron, Dominique
AU - Luce, Sylvie
AU - Debugne, Gwenaëlle
AU - den Bulck, Bulck
AU - Goeminne, Jean Charles
AU - Baitar, Abdelbari
AU - Geboers, Katrien
AU - Petit, Benedicte
AU - Langenaeken, Christine
AU - Van Rijswijk, Ruud
AU - Specenier, Pol
AU - Jerusalem, Guy
AU - Praet, Jean Philippe
AU - Vandenborre, Katherine
AU - Lobelle, Jean Pierre
AU - Lycke, Michelle
AU - Milisen, Koen
AU - Wildiers, Hans
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/11
Y1 - 2019/11
N2 - Objectives: This study aims to investigate health-related quality of life (HRQOL) at baseline and at follow-up in older patients with cancer and to determine prognostic factors for HRQOL decline. Methods: A prospective Belgian multicentre (n = 22) study was performed. Patients ≥70 years with a malignant tumor and abnormal G8 (≤14/17) screening tool were included. Patients underwent geriatric assessment (GA) and HRQOL evaluation with follow up at three months. Uni- and multivariate regression models were performed to determine factors associated (p < .05) with baseline HRQOL and HRQOL decline at follow-up. Results: Results reflect data collected from 3673 patients. A multivariate analysis showed that younger patients, and those with poor Eastern Cooperative Oncology Group – Performance Status (ECOG-PS), specific tumor types (gastrointestinal, gynaecological and thorax) and higher stage had lower baseline HRQOL. In addition worse functional status and presence of pain, fatigue, depression and malnutrition were associated with lower baseline HRQOL. During treatment (n = 2972), improvement in HRQOL was observed in 1037 patients (35%) and a decline in 838 patients (28.2%). In multivariate analysis, stage and presence of baseline comorbidities, pain, fatigue or malnutrition were associated with HRQOL evolution. Conclusion: Baseline HRQOL in older patients with cancer and an abnormal G8 depends on tumor and age related parameters. During follow-up, HRQOL improved in one third of patients, indicating that they may benefit from cancer treatment while one quarter demonstrated a HRQOL decline for which prognostic factors were identified.
AB - Objectives: This study aims to investigate health-related quality of life (HRQOL) at baseline and at follow-up in older patients with cancer and to determine prognostic factors for HRQOL decline. Methods: A prospective Belgian multicentre (n = 22) study was performed. Patients ≥70 years with a malignant tumor and abnormal G8 (≤14/17) screening tool were included. Patients underwent geriatric assessment (GA) and HRQOL evaluation with follow up at three months. Uni- and multivariate regression models were performed to determine factors associated (p < .05) with baseline HRQOL and HRQOL decline at follow-up. Results: Results reflect data collected from 3673 patients. A multivariate analysis showed that younger patients, and those with poor Eastern Cooperative Oncology Group – Performance Status (ECOG-PS), specific tumor types (gastrointestinal, gynaecological and thorax) and higher stage had lower baseline HRQOL. In addition worse functional status and presence of pain, fatigue, depression and malnutrition were associated with lower baseline HRQOL. During treatment (n = 2972), improvement in HRQOL was observed in 1037 patients (35%) and a decline in 838 patients (28.2%). In multivariate analysis, stage and presence of baseline comorbidities, pain, fatigue or malnutrition were associated with HRQOL evolution. Conclusion: Baseline HRQOL in older patients with cancer and an abnormal G8 depends on tumor and age related parameters. During follow-up, HRQOL improved in one third of patients, indicating that they may benefit from cancer treatment while one quarter demonstrated a HRQOL decline for which prognostic factors were identified.
KW - Cancer
KW - Geriatric domains
KW - Health-related quality of life
KW - Older patients
KW - Prognostic factors
UR - http://www.scopus.com/inward/record.url?scp=85064314976&partnerID=8YFLogxK
U2 - 10.1016/j.jgo.2019.03.018
DO - 10.1016/j.jgo.2019.03.018
M3 - Article
C2 - 31005649
AN - SCOPUS:85064314976
SN - 1879-4068
VL - 10
SP - 895
EP - 903
JO - Journal of Geriatric Oncology
JF - Journal of Geriatric Oncology
IS - 6
ER -