GRADE guidelines: 15. Going from evidence to recommendation-determinants of a recommendation's direction and strength.

Jeffrey C. Andrews; Holger J. Schünemann; Andrew D. Oxman; Kevin Pottie; Joerg J. Meerpohl; Pablo Alonso Coello; David Rind; Victor M. Montori; Juan Pablo Brito; Susan Norris; Mahmoud Elbarbary; Piet Post; Mona Nasser; Vijay Shukla; Roman Jaeschke; Jan Brozek; Ben Djulbegovic; Gordon Guyatt

doi:10.1016/j.jclinepi.2013.02.003

GRADE guidelines: 15. Going from evidence to recommendation-determinants of a recommendation's direction and strength.

Jeffrey C. Andrews^*, Holger J. Schünemann, Andrew D. Oxman, Kevin Pottie, Joerg J. Meerpohl, Pablo Alonso Coello, David Rind, Victor M. Montori, Juan Pablo Brito, Susan Norris, Mahmoud Elbarbary, Piet Post, Mona Nasser, Vijay Shukla, Roman Jaeschke, Jan Brozek, Ben Djulbegovic, Gordon Guyatt

^*Corresponding author for this work

Faculty of Health

Research output: Contribution to journal › Article › peer-review

Abstract

In the GRADE approach, the strength of a recommendation reflects the extent to which we can be confident that the composite desirable effects of a management strategy outweigh the composite undesirable effects. This article addresses GRADE's approach to determining the direction and strength of a recommendation. The GRADE describes the balance of desirable and undesirable outcomes of interest among alternative management strategies depending on four domains, namely estimates of effect for desirable and undesirable outcomes of interest, confidence in the estimates of effect, estimates of values and preferences, and resource use. Ultimately, guideline panels must use judgment in integrating these factors to make a strong or weak recommendation for or against an intervention.

Original language	English
Pages (from-to)	726-735
Number of pages	0
Journal	J Clin Epidemiol
Volume	66
Issue number	7
DOIs	https://doi.org/10.1016/j.jclinepi.2013.02.003
Publication status	Published - Jul 2013

Keywords

Canada
Evidence-Based Medicine
Germany
Humans
Practice Guidelines as Topic
Pulmonary Disease
Chronic Obstructive
Quality Assurance
Health Care
Research Design
Risk Assessment
Treatment Failure
Treatment Outcome
United States

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Andrews, J. C., Schünemann, H. J., Oxman, A. D., Pottie, K., Meerpohl, J. J., Coello, P. A., Rind, D., Montori, V. M., Brito, J. P., Norris, S., Elbarbary, M., Post, P., Nasser, M., Shukla, V., Jaeschke, R., Brozek, J., Djulbegovic, B., & Guyatt, G. (2013). GRADE guidelines: 15. Going from evidence to recommendation-determinants of a recommendation's direction and strength. J Clin Epidemiol, 66(7), 726-735. https://doi.org/10.1016/j.jclinepi.2013.02.003

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title = "GRADE guidelines: 15. Going from evidence to recommendation-determinants of a recommendation's direction and strength.",

abstract = "In the GRADE approach, the strength of a recommendation reflects the extent to which we can be confident that the composite desirable effects of a management strategy outweigh the composite undesirable effects. This article addresses GRADE's approach to determining the direction and strength of a recommendation. The GRADE describes the balance of desirable and undesirable outcomes of interest among alternative management strategies depending on four domains, namely estimates of effect for desirable and undesirable outcomes of interest, confidence in the estimates of effect, estimates of values and preferences, and resource use. Ultimately, guideline panels must use judgment in integrating these factors to make a strong or weak recommendation for or against an intervention.",

keywords = "Canada, Evidence-Based Medicine, Germany, Humans, Practice Guidelines as Topic, Pulmonary Disease, Chronic Obstructive, Quality Assurance, Health Care, Research Design, Risk Assessment, Treatment Failure, Treatment Outcome, United States",

author = "Andrews, {Jeffrey C.} and Sch{\"u}nemann, {Holger J.} and Oxman, {Andrew D.} and Kevin Pottie and Meerpohl, {Joerg J.} and Coello, {Pablo Alonso} and David Rind and Montori, {Victor M.} and Brito, {Juan Pablo} and Susan Norris and Mahmoud Elbarbary and Piet Post and Mona Nasser and Vijay Shukla and Roman Jaeschke and Jan Brozek and Ben Djulbegovic and Gordon Guyatt",

year = "2013",

month = jul,

doi = "10.1016/j.jclinepi.2013.02.003",

language = "English",

volume = "66",

pages = "726--735",

journal = "J Clin Epidemiol",

issn = "1878-5921",

number = "7",

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Andrews, JC, Schünemann, HJ, Oxman, AD, Pottie, K, Meerpohl, JJ, Coello, PA, Rind, D, Montori, VM, Brito, JP, Norris, S, Elbarbary, M, Post, P, Nasser, M, Shukla, V, Jaeschke, R, Brozek, J, Djulbegovic, B & Guyatt, G 2013, 'GRADE guidelines: 15. Going from evidence to recommendation-determinants of a recommendation's direction and strength.', J Clin Epidemiol, vol. 66, no. 7, pp. 726-735. https://doi.org/10.1016/j.jclinepi.2013.02.003

TY - JOUR

T1 - GRADE guidelines: 15. Going from evidence to recommendation-determinants of a recommendation's direction and strength.

AU - Andrews, Jeffrey C.

AU - Schünemann, Holger J.

AU - Oxman, Andrew D.

AU - Pottie, Kevin

AU - Meerpohl, Joerg J.

AU - Coello, Pablo Alonso

AU - Rind, David

AU - Montori, Victor M.

AU - Brito, Juan Pablo

AU - Norris, Susan

AU - Elbarbary, Mahmoud

AU - Post, Piet

AU - Nasser, Mona

AU - Shukla, Vijay

AU - Jaeschke, Roman

AU - Brozek, Jan

AU - Djulbegovic, Ben

AU - Guyatt, Gordon

PY - 2013/7

Y1 - 2013/7

N2 - In the GRADE approach, the strength of a recommendation reflects the extent to which we can be confident that the composite desirable effects of a management strategy outweigh the composite undesirable effects. This article addresses GRADE's approach to determining the direction and strength of a recommendation. The GRADE describes the balance of desirable and undesirable outcomes of interest among alternative management strategies depending on four domains, namely estimates of effect for desirable and undesirable outcomes of interest, confidence in the estimates of effect, estimates of values and preferences, and resource use. Ultimately, guideline panels must use judgment in integrating these factors to make a strong or weak recommendation for or against an intervention.

AB - In the GRADE approach, the strength of a recommendation reflects the extent to which we can be confident that the composite desirable effects of a management strategy outweigh the composite undesirable effects. This article addresses GRADE's approach to determining the direction and strength of a recommendation. The GRADE describes the balance of desirable and undesirable outcomes of interest among alternative management strategies depending on four domains, namely estimates of effect for desirable and undesirable outcomes of interest, confidence in the estimates of effect, estimates of values and preferences, and resource use. Ultimately, guideline panels must use judgment in integrating these factors to make a strong or weak recommendation for or against an intervention.

KW - Canada

KW - Evidence-Based Medicine

KW - Germany

KW - Humans

KW - Practice Guidelines as Topic

KW - Pulmonary Disease

KW - Chronic Obstructive

KW - Quality Assurance

KW - Health Care

KW - Research Design

KW - Risk Assessment

KW - Treatment Failure

KW - Treatment Outcome

KW - United States

U2 - 10.1016/j.jclinepi.2013.02.003

DO - 10.1016/j.jclinepi.2013.02.003

M3 - Article

SN - 1878-5921

VL - 66

SP - 726

EP - 735

JO - J Clin Epidemiol

JF - J Clin Epidemiol

IS - 7

ER -

GRADE guidelines: 15. Going from evidence to recommendation-determinants of a recommendation's direction and strength.

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Keywords

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