TY - JOUR
T1 - GRADE guidelines: 14. Going from evidence to recommendations: the significance and presentation of recommendations.
AU - Andrews, Jeff
AU - Guyatt, Gordon
AU - Oxman, Andrew D.
AU - Alderson, Phil
AU - Dahm, Philipp
AU - Falck-Ytter, Yngve
AU - Nasser, Mona
AU - Meerpohl, Joerg
AU - Post, Piet N.
AU - Kunz, Regina
AU - Brozek, Jan
AU - Vist, Gunn
AU - Rind, David
AU - Akl, Elie A.
AU - Schünemann, Holger J.
PY - 2013/7
Y1 - 2013/7
N2 - This article describes the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach to classifying the direction and strength of recommendations. The strength of a recommendation, separated into strong and weak, is defined as the extent to which one can be confident that the desirable effects of an intervention outweigh its undesirable effects. Alternative terms for a weak recommendation include conditional, discretionary, or qualified. The strength of a recommendation has specific implications for patients, the public, clinicians, and policy makers. Occasionally, guideline developers may choose to make "only-in-research" recommendations. Although panels may choose not to make recommendations, this choice leaves those looking for answers from guidelines without the guidance they are seeking. GRADE therefore encourages panels to, wherever possible, offer recommendations.
AB - This article describes the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach to classifying the direction and strength of recommendations. The strength of a recommendation, separated into strong and weak, is defined as the extent to which one can be confident that the desirable effects of an intervention outweigh its undesirable effects. Alternative terms for a weak recommendation include conditional, discretionary, or qualified. The strength of a recommendation has specific implications for patients, the public, clinicians, and policy makers. Occasionally, guideline developers may choose to make "only-in-research" recommendations. Although panels may choose not to make recommendations, this choice leaves those looking for answers from guidelines without the guidance they are seeking. GRADE therefore encourages panels to, wherever possible, offer recommendations.
KW - Clinical Protocols
KW - Evidence-Based Medicine
KW - Humans
KW - Practice Guidelines as Topic
KW - United States
U2 - 10.1016/j.jclinepi.2012.03.013
DO - 10.1016/j.jclinepi.2012.03.013
M3 - Article
SN - 1878-5921
VL - 66
SP - 719
EP - 725
JO - J Clin Epidemiol
JF - J Clin Epidemiol
IS - 7
ER -