TY - JOUR
T1 - Genetic variants associated with longitudinal changes in brain structure across the lifespan
AU - the IMAGEN Consortium
AU - Brouwer, Rachel M.
AU - Klein, Marieke
AU - Grasby, Katrina L.
AU - Schnack, Hugo G.
AU - Jahanshad, Neda
AU - Teeuw, Jalmar
AU - Thomopoulos, Sophia I.
AU - Sprooten, Emma
AU - Franz, Carol E.
AU - Gogtay, Nitin
AU - Kremen, William S.
AU - Panizzon, Matthew S.
AU - Olde Loohuis, Loes M.
AU - Whelan, Christopher D.
AU - Aghajani, Moji
AU - Alloza, Clara
AU - Alnæs, Dag
AU - Artiges, Eric
AU - Ayesa-Arriola, Rosa
AU - Barker, Gareth J.
AU - Bastin, Mark E.
AU - Blok, Elisabet
AU - Bøen, Erlend
AU - Breukelaar, Isabella A.
AU - Bright, Joanna K.
AU - Buimer, Elizabeth E.L.
AU - Bülow, Robin
AU - Cannon, Dara M.
AU - Ciufolini, Simone
AU - Crossley, Nicolas A.
AU - Damatac, Christienne G.
AU - Dazzan, Paola
AU - de Mol, Casper L.
AU - de Zwarte, Sonja M.C.
AU - Desrivières, Sylvane
AU - Díaz-Caneja, Covadonga M.
AU - Doan, Nhat Trung
AU - Dohm, Katharina
AU - Fröhner, Juliane H.
AU - Goltermann, Janik
AU - Grigis, Antoine
AU - Grotegerd, Dominik
AU - Han, Laura K.M.
AU - Harris, Mathew A.
AU - Hartman, Catharina A.
AU - Heany, Sarah J.
AU - Heindel, Walter
AU - Heslenfeld, Dirk J.
AU - Hohmann, Sarah
AU - Ittermann, Bernd
AU - Hoare, Jacqueline
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2022/4/1
Y1 - 2022/4/1
N2 - Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and aging.
AB - Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and aging.
UR - https://www.scopus.com/pages/publications/85127652829
U2 - 10.1038/s41593-022-01042-4
DO - 10.1038/s41593-022-01042-4
M3 - Article
C2 - 35383335
AN - SCOPUS:85127652829
SN - 1097-6256
VL - 25
SP - 421
EP - 432
JO - Nature Neuroscience
JF - Nature Neuroscience
IS - 4
ER -