TY - JOUR
T1 - Genetic underpinnings in Alzheimer's disease - a review
AU - Moustafa, Ahmed A
AU - Hassan, Mubashir
AU - Hewedi, Doaa H
AU - Hewedi, Iman
AU - Garami, Julia K
AU - Al Ashwal, Hany
AU - Zaki, Nazar
AU - Seo, Sung-Yum
AU - Cutsuridis, Vassilis
AU - Angulo, Sergio L
AU - Natesh, Joman Y
AU - Herzallah, Mohammad M
AU - Frydecka, Dorota
AU - Misiak, Błażej
AU - Salama, Mohamed
AU - Mohamed, Wael
AU - El Haj, Mohamad
AU - Hornberger, Michael
PY - 2018/1/26
Y1 - 2018/1/26
N2 - In this review, we discuss the genetic etiologies of Alzheimer's disease (AD). Furthermore, we review genetic links to protein signaling pathways as novel pharmacological targets to treat AD. Moreover, we also discuss the clumps of AD-m ediated genes according to their single nucleotide polymorphism mutations. Rigorous data mining approaches justified the significant role of genes in AD prevalence. Pedigree analysis and twin studies suggest that genetic components are part of the etiology, rather than only being risk factors for AD. The first autosomal dominant mutation in the amyloid precursor protein (APP) gene was described in 1991. Later, AD was also associated with mutated early-onset (presenilin 1/2, PSEN1/2 and APP) and late-onset (apolipoprotein E, ApoE) genes. Genome-wide association and linkage analysis studies with identified multiple genomic areas have implications for the treatment of AD. We conclude this review with future directions and clinical implications of genetic research in AD.
AB - In this review, we discuss the genetic etiologies of Alzheimer's disease (AD). Furthermore, we review genetic links to protein signaling pathways as novel pharmacological targets to treat AD. Moreover, we also discuss the clumps of AD-m ediated genes according to their single nucleotide polymorphism mutations. Rigorous data mining approaches justified the significant role of genes in AD prevalence. Pedigree analysis and twin studies suggest that genetic components are part of the etiology, rather than only being risk factors for AD. The first autosomal dominant mutation in the amyloid precursor protein (APP) gene was described in 1991. Later, AD was also associated with mutated early-onset (presenilin 1/2, PSEN1/2 and APP) and late-onset (apolipoprotein E, ApoE) genes. Genome-wide association and linkage analysis studies with identified multiple genomic areas have implications for the treatment of AD. We conclude this review with future directions and clinical implications of genetic research in AD.
KW - Alzheimer Disease/genetics
KW - Amyloid beta-Protein Precursor/genetics
KW - Genetic Predisposition to Disease/genetics
KW - Genome-Wide Association Study
KW - Humans
KW - Polymorphism, Single Nucleotide
KW - Presenilin-1/genetics
U2 - 10.1515/revneuro-2017-0036
DO - 10.1515/revneuro-2017-0036
M3 - Article
C2 - 28949931
SN - 0334-1763
VL - 29
SP - 21
EP - 38
JO - Reviews in the Neurosciences
JF - Reviews in the Neurosciences
IS - 1
ER -