Genetic mechanisms of critical illness in COVID-19

Erola Pairo-Castineira; Sara Clohisey; Lucija Klaric; Andrew D. Bretherick; Konrad Rawlik; Dorota Pasko; Susan Walker; Nick Parkinson; Max Head Fourman; Clark D. Russell; James Furniss; Anne Richmond; Elvina Gountouna; Nicola Wrobel; David Harrison; Bo Wang; Yang Wu; Alison Meynert; Fiona Griffiths; Wilna Oosthuyzen; Athanasios Kousathanas; Loukas Moutsianas; Z Yang; Ranran Zhai; Chenqing Zheng; Graeme Grimes; Rupert Beale; Jonathan Millar; Barbara Shih; Sean Keating; Marie Zechner; Chris Haley; David J. Porteous; Caroline Hayward; J Yang; Julian Knight; Charlotte Summers; Manu Shankar-Hari; Paul Klenerman; Lance Turtle; Antonia Ho; Shona C. Moore; Charles Hinds; Peter Horby; Alistair Nichol; David Maslove; Lowell Ling; Danny McAuley; Hugh Montgomery; T Walsh; AC Pereira; A Renieri; X Shen; CP Ponting; A Fawkes; A Tenesa; M Caulfield; R Scott; K Rowan; L Murphy; PJM Openshaw; MG Semple; A Law; V Vitart; JF Wilson; JK Baillie; N Nikitas; Daniel Martin

doi:10.1038/s41586-020-03065-y

Genetic mechanisms of critical illness in COVID-19

Erola Pairo-Castineira
, Sara Clohisey
, Lucija Klaric
, Andrew D. Bretherick
, Konrad Rawlik
, Dorota Pasko
, Susan Walker
, Nick Parkinson
, Max Head Fourman
, Clark D. Russell
, James Furniss
, Anne Richmond
, Elvina Gountouna
, Nicola Wrobel
, David Harrison
, Bo Wang
, Yang Wu
, Alison Meynert
, Fiona Griffiths
, Wilna Oosthuyzen

Athanasios Kousathanas, Loukas Moutsianas, Z Yang, Ranran Zhai, Chenqing Zheng, Graeme Grimes, Rupert Beale, Jonathan Millar, Barbara Shih, Sean Keating, Marie Zechner, Chris Haley, David J. Porteous, Caroline Hayward, J Yang, Julian Knight, Charlotte Summers, Manu Shankar-Hari, Paul Klenerman, Lance Turtle, Antonia Ho, Shona C. Moore, Charles Hinds, Peter Horby, Alistair Nichol, David Maslove, Lowell Ling, Danny McAuley, Hugh Montgomery, T Walsh, AC Pereira, A Renieri, X Shen, CP Ponting, A Fawkes, A Tenesa, M Caulfield, R Scott, K Rowan, L Murphy, PJM Openshaw, MG Semple, A Law, V Vitart, JF Wilson, JK Baillie, N Nikitas, Daniel Martin

University of Edinburgh
Genomics England
Intensive Care National Audit and Research Centre
University of Queensland
Sun Yat-Sen University
The Francis Crick Institute
University of Oxford
Cambridge University Hospitals NHS Foundation Trust
University of Cambridge
Guy's and St Thomas' NHS Foundation Trust
King's College London
John Radcliffe Hospital
Liverpool University Hospitals NHS Foundation Trust
University of Liverpool
MRC-University of Glasgow Centre for Virus Research
Queen Mary University of London
Alfred Health
Monash University
University College Dublin
Queen's University Kingston
Chinese University of Hong Kong
Queen's University Belfast
Royal Victoria Hospital Belfast
University College London

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	92-98
Number of pages	0
Journal	Nature
Volume	591
Issue number	7848
Early online date	11 Dec 2020
DOIs	https://doi.org/10.1038/s41586-020-03065-y
Publication status	Published - 4 Mar 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1038/s41586-020-03065-y

Cite this

Pairo-Castineira, E., Clohisey, S., Klaric, L., Bretherick, A. D., Rawlik, K., Pasko, D., Walker, S., Parkinson, N., Fourman, M. H., Russell, C. D., Furniss, J., Richmond, A., Gountouna, E., Wrobel, N., Harrison, D., Wang, B., Wu, Y., Meynert, A., Griffiths, F., ... Martin, D. (2021). Genetic mechanisms of critical illness in COVID-19. Nature, 591(7848), 92-98. https://doi.org/10.1038/s41586-020-03065-y

@article{0e9f5bf4d4ca4a63927283dee75579d2,

title = "Genetic mechanisms of critical illness in COVID-19",

author = "Erola Pairo-Castineira and Sara Clohisey and Lucija Klaric and Bretherick, \{Andrew D.\} and Konrad Rawlik and Dorota Pasko and Susan Walker and Nick Parkinson and Fourman, \{Max Head\} and Russell, \{Clark D.\} and James Furniss and Anne Richmond and Elvina Gountouna and Nicola Wrobel and David Harrison and Bo Wang and Yang Wu and Alison Meynert and Fiona Griffiths and Wilna Oosthuyzen and Athanasios Kousathanas and Loukas Moutsianas and Z Yang and Ranran Zhai and Chenqing Zheng and Graeme Grimes and Rupert Beale and Jonathan Millar and Barbara Shih and Sean Keating and Marie Zechner and Chris Haley and Porteous, \{David J.\} and Caroline Hayward and J Yang and Julian Knight and Charlotte Summers and Manu Shankar-Hari and Paul Klenerman and Lance Turtle and Antonia Ho and Moore, \{Shona C.\} and Charles Hinds and Peter Horby and Alistair Nichol and David Maslove and Lowell Ling and Danny McAuley and Hugh Montgomery and T Walsh and AC Pereira and A Renieri and X Shen and CP Ponting and A Fawkes and A Tenesa and M Caulfield and R Scott and K Rowan and L Murphy and PJM Openshaw and MG Semple and A Law and V Vitart and JF Wilson and JK Baillie and N Nikitas and Daniel Martin",

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doi = "10.1038/s41586-020-03065-y",

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Pairo-Castineira, E, Clohisey, S, Klaric, L, Bretherick, AD, Rawlik, K, Pasko, D, Walker, S, Parkinson, N, Fourman, MH, Russell, CD, Furniss, J, Richmond, A, Gountouna, E, Wrobel, N, Harrison, D, Wang, B, Wu, Y, Meynert, A, Griffiths, F, Oosthuyzen, W, Kousathanas, A, Moutsianas, L, Yang, Z, Zhai, R, Zheng, C, Grimes, G, Beale, R, Millar, J, Shih, B, Keating, S, Zechner, M, Haley, C, Porteous, DJ, Hayward, C, Yang, J, Knight, J, Summers, C, Shankar-Hari, M, Klenerman, P, Turtle, L, Ho, A, Moore, SC, Hinds, C, Horby, P, Nichol, A, Maslove, D, Ling, L, McAuley, D, Montgomery, H, Walsh, T, Pereira, AC, Renieri, A, Shen, X, Ponting, CP, Fawkes, A, Tenesa, A, Caulfield, M, Scott, R, Rowan, K, Murphy, L, Openshaw, PJM, Semple, MG, Law, A, Vitart, V, Wilson, JF, Baillie, JK, Nikitas, N & Martin, D 2021, 'Genetic mechanisms of critical illness in COVID-19', Nature, vol. 591, no. 7848, pp. 92-98. https://doi.org/10.1038/s41586-020-03065-y

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AU - Klaric, Lucija

AU - Bretherick, Andrew D.

AU - Rawlik, Konrad

AU - Pasko, Dorota

AU - Walker, Susan

AU - Parkinson, Nick

AU - Fourman, Max Head

AU - Russell, Clark D.

AU - Furniss, James

AU - Richmond, Anne

AU - Gountouna, Elvina

AU - Wrobel, Nicola

AU - Harrison, David

AU - Wang, Bo

AU - Wu, Yang

AU - Meynert, Alison

AU - Griffiths, Fiona

AU - Oosthuyzen, Wilna

AU - Kousathanas, Athanasios

AU - Moutsianas, Loukas

AU - Yang, Z

AU - Zhai, Ranran

AU - Zheng, Chenqing

AU - Grimes, Graeme

AU - Beale, Rupert

AU - Millar, Jonathan

AU - Shih, Barbara

AU - Keating, Sean

AU - Zechner, Marie

AU - Haley, Chris

AU - Porteous, David J.

AU - Hayward, Caroline

AU - Yang, J

AU - Knight, Julian

AU - Summers, Charlotte

AU - Shankar-Hari, Manu

AU - Klenerman, Paul

AU - Turtle, Lance

AU - Ho, Antonia

AU - Moore, Shona C.

AU - Hinds, Charles

AU - Horby, Peter

AU - Nichol, Alistair

AU - Maslove, David

AU - Ling, Lowell

AU - McAuley, Danny

AU - Montgomery, Hugh

AU - Walsh, T

AU - Pereira, AC

AU - Renieri, A

AU - Shen, X

AU - Ponting, CP

AU - Fawkes, A

AU - Tenesa, A

AU - Caulfield, M

AU - Scott, R

AU - Rowan, K

AU - Murphy, L

AU - Openshaw, PJM

AU - Semple, MG

AU - Law, A

AU - Vitart, V

AU - Wilson, JF

AU - Baillie, JK

AU - Nikitas, N

AU - Martin, Daniel

PY - 2021/3/4

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DO - 10.1038/s41586-020-03065-y

M3 - Article

SN - 0028-0836

VL - 591

SP - 92

EP - 98

JO - Nature

JF - Nature

IS - 7848

ER -