Gene probe analysis demonstrates independent clonal evolution of co‐existent chronic myeloid and chronic lymphocytic leukaemia

P. J. Browett; J. Pattinson; J. Pinkney; A. V. Hoffbrand; J. D. Norton

doi:10.1111/j.1600-0609.1988.tb00818.x

Gene probe analysis demonstrates independent clonal evolution of co‐existent chronic myeloid and chronic lymphocytic leukaemia

P. J. Browett
, J. Pattinson
, J. Pinkney
, A. V. Hoffbrand
, J. D. Norton^*

^*Corresponding author for this work

Peninsula Medical School

The Royal Free Hospital
East Kent Hospitals University NHS Foundation Trust

Research output: Contribution to journal › Article › peer-review

Abstract

We describe a case of Philadelphia‐positive chronic myeloid leukaemia occurring simultaneously with B‐cell chronic lymphocytic leukaemia in a 69‐yr‐old male. Gene probe analysis of DNA from both peripheral blood and bone marrow provided evidence for the independent evolution of 2 clones in this case, with a predominant population showing immunoglobulin heavy chain gene rearrangement and a smaller population showing a rearrangement within the breakpoint cluster region of chromosome 22.

Original language	English
Pages (from-to)	181-184
Number of pages	0
Journal	European Journal of Haematology
Volume	40
Issue number	2
DOIs	https://doi.org/10.1111/j.1600-0609.1988.tb00818.x
Publication status	Published - Feb 1988

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1111/j.1600-0609.1988.tb00818.x

Cite this

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title = "Gene probe analysis demonstrates independent clonal evolution of co‐existent chronic myeloid and chronic lymphocytic leukaemia",

abstract = "We describe a case of Philadelphia‐positive chronic myeloid leukaemia occurring simultaneously with B‐cell chronic lymphocytic leukaemia in a 69‐yr‐old male. Gene probe analysis of DNA from both peripheral blood and bone marrow provided evidence for the independent evolution of 2 clones in this case, with a predominant population showing immunoglobulin heavy chain gene rearrangement and a smaller population showing a rearrangement within the breakpoint cluster region of chromosome 22.",

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AU - Browett, P. J.

AU - Pattinson, J.

AU - Pinkney, J.

AU - Hoffbrand, A. V.

AU - Norton, J. D.

PY - 1988/2

Y1 - 1988/2

N2 - We describe a case of Philadelphia‐positive chronic myeloid leukaemia occurring simultaneously with B‐cell chronic lymphocytic leukaemia in a 69‐yr‐old male. Gene probe analysis of DNA from both peripheral blood and bone marrow provided evidence for the independent evolution of 2 clones in this case, with a predominant population showing immunoglobulin heavy chain gene rearrangement and a smaller population showing a rearrangement within the breakpoint cluster region of chromosome 22.

AB - We describe a case of Philadelphia‐positive chronic myeloid leukaemia occurring simultaneously with B‐cell chronic lymphocytic leukaemia in a 69‐yr‐old male. Gene probe analysis of DNA from both peripheral blood and bone marrow provided evidence for the independent evolution of 2 clones in this case, with a predominant population showing immunoglobulin heavy chain gene rearrangement and a smaller population showing a rearrangement within the breakpoint cluster region of chromosome 22.

U2 - 10.1111/j.1600-0609.1988.tb00818.x

DO - 10.1111/j.1600-0609.1988.tb00818.x

M3 - Article

SN - 0902-4441

VL - 40

SP - 181

EP - 184

JO - European Journal of Haematology

JF - European Journal of Haematology

IS - 2

ER -

Gene probe analysis demonstrates independent clonal evolution of co‐existent chronic myeloid and chronic lymphocytic leukaemia

Abstract

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