Gene probe analysis demonstrates independent clonal evolution of co‐existent chronic myeloid and chronic lymphocytic leukaemia

P. J. Browett, J. Pattinson, J. Pinkney, A. V. Hoffbrand, J. D. Norton*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

<jats:p>We describe a case of Philadelphia‐positive chronic myeloid leukaemia occurring simultaneously with B‐cell chronic lymphocytic leukaemia in a 69‐yr‐old male. Gene probe analysis of DNA from both peripheral blood and bone marrow provided evidence for the independent evolution of 2 clones in this case, with a predominant population showing immunoglobulin heavy chain gene rearrangement and a smaller population showing a rearrangement within the breakpoint cluster region of chromosome 22.</jats:p>
Original languageEnglish
Pages (from-to)181-184
Number of pages0
JournalEuropean Journal of Haematology
Volume40
Issue number2
DOIs
Publication statusPublished - Feb 1988

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