GDNF/RET signaling in dopamine neurons in vivo

James A. Conway; Selvi Ince; Stephanie Black; Edgar R. Kramer

doi:10.1007/s00441-020-03268-9

GDNF/RET signaling in dopamine neurons in vivo

James A. Conway
, Selvi Ince
, Stephanie Black
, Edgar R. Kramer^*

^*Corresponding author for this work

University of Plymouth

Research output: Contribution to journal › Review article › peer-review

Abstract

The glial cell line–derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal both in tandem and separately to exert many vital functions in the midbrain dopamine system. It is known that Ret has effects on maintenance, physiology, protection and regeneration in the midbrain dopamine system, with the physiological functions of GDNF still somewhat unclear. Notwithstanding, Ret ligands, such as GDNF, are considered as promising candidates for neuroprotection and/or regeneration in Parkinson’s disease, although data from clinical trials are so far inconclusive. In this review, we discuss the current knowledge of GDNF/Ret signaling in the dopamine system in vivo as well as crosstalk with pathology-associated proteins and their signaling in mammals.

Original language	English
Pages (from-to)	135-146
Number of pages	12
Journal	Cell and Tissue Research
Volume	382
Issue number	1
DOIs	https://doi.org/10.1007/s00441-020-03268-9
Publication status	Published - 1 Oct 2020

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology
Cell Biology

Keywords

Cell survival
GDNF
Midbrain dopamine system
Protection
Regeneration
Ret

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10.1007/s00441-020-03268-9

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title = "GDNF/RET signaling in dopamine neurons in vivo",

abstract = "The glial cell line–derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal both in tandem and separately to exert many vital functions in the midbrain dopamine system. It is known that Ret has effects on maintenance, physiology, protection and regeneration in the midbrain dopamine system, with the physiological functions of GDNF still somewhat unclear. Notwithstanding, Ret ligands, such as GDNF, are considered as promising candidates for neuroprotection and/or regeneration in Parkinson{\textquoteright}s disease, although data from clinical trials are so far inconclusive. In this review, we discuss the current knowledge of GDNF/Ret signaling in the dopamine system in vivo as well as crosstalk with pathology-associated proteins and their signaling in mammals.",

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T1 - GDNF/RET signaling in dopamine neurons in vivo

AU - Conway, James A.

AU - Ince, Selvi

AU - Black, Stephanie

AU - Kramer, Edgar R.

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N2 - The glial cell line–derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal both in tandem and separately to exert many vital functions in the midbrain dopamine system. It is known that Ret has effects on maintenance, physiology, protection and regeneration in the midbrain dopamine system, with the physiological functions of GDNF still somewhat unclear. Notwithstanding, Ret ligands, such as GDNF, are considered as promising candidates for neuroprotection and/or regeneration in Parkinson’s disease, although data from clinical trials are so far inconclusive. In this review, we discuss the current knowledge of GDNF/Ret signaling in the dopamine system in vivo as well as crosstalk with pathology-associated proteins and their signaling in mammals.

AB - The glial cell line–derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal both in tandem and separately to exert many vital functions in the midbrain dopamine system. It is known that Ret has effects on maintenance, physiology, protection and regeneration in the midbrain dopamine system, with the physiological functions of GDNF still somewhat unclear. Notwithstanding, Ret ligands, such as GDNF, are considered as promising candidates for neuroprotection and/or regeneration in Parkinson’s disease, although data from clinical trials are so far inconclusive. In this review, we discuss the current knowledge of GDNF/Ret signaling in the dopamine system in vivo as well as crosstalk with pathology-associated proteins and their signaling in mammals.

KW - Cell survival

KW - GDNF

KW - Midbrain dopamine system

KW - Protection

KW - Regeneration

KW - Ret

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DO - 10.1007/s00441-020-03268-9

M3 - Review article

C2 - 32870383

AN - SCOPUS:85090061316

SN - 0302-766X

VL - 382

SP - 135

EP - 146

JO - Cell and Tissue Research

JF - Cell and Tissue Research

IS - 1

ER -

GDNF/RET signaling in dopamine neurons in vivo

Abstract

ASJC Scopus subject areas

Keywords

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